Voren Side Effects

Voren is a nonsteroidal anti-inflammatory drug (NSAID) commonly used to relieve pain and reduce inflammation in conditions like arthritis, musculoskeletal disorders, and various other painful conditions. While it can be effective in managing these symptoms, it is essential to be aware of potential side effects.

Gastrointestinal Side Effects

Using Voren (Diclofenac Sodium) can cause the following gastrointestinal issues:

• Stomach pain or discomfort
• Heartburn
• Nausea
• Vomiting
• Diarrhea
• Indigestion
• Gas or bloating
• Ulcers or bleeding in the stomach or intestines (less common but more serious)

Cardiovascular Side Effects

Voren may cause the following cardiovascular problems:

• Increased blood pressure
• Fluid retention and swelling
• Risk of heart attack or stroke, especially with long-term use or in people with preexisting cardiovascular conditions

Side Effects on Kidneys (Renal Problems)

The use of Voren affects the kidneys, including:

• Reduced kidney function
• Fluid retention

Central Nervous System Effects

Voren is not a centrally-acting drug but sometimes it can create  CNS issues, such as:

• Headache
• Dizziness
• Drowsiness

Liver Effects

Voren may cause the following liver problems:

• Elevated liver enzymes (measured through blood tests)
• Liver toxicity (rare)

Hematologic (Blood) Effects

• Increased risk of bleeding, especially in individuals with bleeding disorders
• Decreased blood cell counts (e.g., anemia, low platelet count)

Respiratory Effects

• Shortness of breath (rare)

Allergic Reactions

• Allergic reactions such as hives, itching, swelling, or difficulty breathing (anaphylaxis is rare but can be life-threatening)

Voren is one of the leading brands of Diclofenac Sodium, manufactured and marketed by Asian Continental (Pvt) Ltd, Pakistan.

Presently, Voren is available in Tablets, Capsules, and Injection forms

Voren Tablet : 25mg, and 50mg strengths

Voren SR Tablet : 100mg strength

Voren Capsule : 50mg strength

Voren Injection (3ml) : 25mg/ml strength

1. Other NSAIDs: Concurrent use of multiple NSAIDs, including Voren, can increase the risk of gastrointestinal side effects and complications.
2. Anticoagulants/Antiplatelet Drugs: Voren can enhance the effects of anticoagulants (blood thinners) such as warfarin, as well as antiplatelet drugs like aspirin, which can increase the risk of bleeding.
3. Corticosteroids: Combining Voren with corticosteroids, such as prednisone, may increase the risk of gastrointestinal bleeding and ulcer formation.
4. Selective Serotonin Reuptake Inhibitors (SSRIs) and Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs): Concurrent use of diclofenac with these antidepressant medications can increase the risk of bleeding, particularly in the gastrointestinal tract.
5. ACE Inhibitors and Angiotensin II Receptor Blockers (ARBs): These drugs, commonly used to treat high blood pressure and heart conditions, may have their blood pressure-lowering effects reduced when taken with Voren.
6. Diuretics (Water Pills): Combining Voren with diuretics may reduce the effectiveness of diuretics and potentially lead to an increase in blood pressure.
7. Methotrexate: Voren can increase the blood levels of methotrexate, a medication used to treat certain autoimmune diseases and cancers, potentially leading to toxic effects.
8. Lithium: Diclofenac can increase the levels of lithium in the blood, which may lead to lithium toxicity.
9. Cyclosporine and Tacrolimus: These immunosuppressant drugs used in organ transplantation can have their blood levels increased when taken with Voren, potentially leading to kidney problems.
10. Digoxin: Voren can increase the levels of digoxin in the blood, which can lead to digoxin toxicity.
11. Antidiabetic Medications: Voren may affect blood sugar levels and interact with antidiabetic medications, potentially requiring adjustments in diabetes management.
12. Quinolone Antibiotics: There have been reports of an increased risk of seizures when Voren is taken with quinolone antibiotics, such as ciprofloxacin.
13. Phenytoin: Voren can increase the levels of phenytoin in the blood, potentially leading to phenytoin toxicity.
14. CYP2C9 Inhibitors and Inducers: Voren is metabolized by the CYP2C9 enzyme. Drugs that inhibit or induce this enzyme may affect the levels of diclofenac sodium in the blood.