No-spa tablet is used to treat painful muscle spasms and cramps. It is an antispasmodic drug primarily used to relax the uterus, bladder, and intestine muscles. The following are some common and off-label uses of No-spa tablets:

Common Uses of No-Spa Tablet

  1. Smooth Muscle Spasm: No-spa tablet is commonly used to relieve spasms or contractions in smooth muscles. This includes conditions such as:
    • Gastrointestinal spasms: It can be used to alleviate spasms in the gastrointestinal tract, which may occur in conditions like irritable bowel syndrome (IBS).
    • Uterine spasms: No-spa is sometimes used to relieve spasms in the uterus, making it helpful in conditions like dysmenorrhea (painful menstruation) and other uterine-related issues.
  2. Biliary Disorders: No-spa tablet may be used to treat spasms in the biliary tract, which includes the ducts that carry bile from the liver to the small intestine. This can be helpful in conditions such as biliary colic.
  3. Renal Colic: No-spa tablet may be employed in the management of spasms associated with renal colic, which is severe pain caused by the passage of kidney stones.
  4. Other Smooth Muscle Spasms: No-spa tablets can be used for various other conditions where smooth muscle spasms are involved, as determined by a healthcare professional.

Off-label Uses of No-spa Tablet

Pain Management:

  • Headaches: No-spa may be effective in relieving tension headaches and migraines, possibly due to its muscle relaxant properties.
  • Neuralgia: No-spa tablet may be used off-label for pain associated with neuralgia, such as trigeminal neuralgia.

Neurological Conditions:

  • Parkinson’s disease: Early research suggests No-spa tablet might improve symptoms like tremors and rigidity in Parkinson’s disease patients.
  • Dystonia: Limited evidence indicates No-spa tablet could help manage dystonia, a movement disorder characterized by involuntary muscle contractions.

Other off-label Uses:

  • Menstrual cramps: No-spa tablet is commonly used off-label to relieve menstrual cramps due to its antispasmodic effect on uterine muscles.
  • Pregnancy: In some countries, No-spa tablet is used off-label to shorten labor or relieve pregnancy-related pain, but its safety and efficacy in this context are still under investigation.
  • Respiratory conditions: Some studies suggest No-spa tablets might help manage asthma and chronic obstructive pulmonary disease (COPD) by relaxing airways.
No-spa Uses and Indications

What is No-spa?

No-spa is one of the leading brands of Drotaverine, manufactured and marketed by Sanofi Pharmaceutical.

No-spa Alternatives : Other Similar Brands

Below are some available similar brands that can be used as an alternative to No-spa:

  • Relispa : Searl, Pakistan.
  • Drt : Macter International (Pvt) Ltd.
  • Dytra : Tabros Pharma.
  • Durdgone : Adamjee Pharmaceuticals (Pvt) Ltd.
  • HI-SPA : Helix Pharma (Pvt) Ltd.
  • Spa X : Noa Hemis Pharmaceuticals.
  • Bioverine : Biorex Pharmaceuticals.
  • Dot : Acme Laboratories Pakistan (Pvt) Ltd.
  • Dropa : Alliance Pharmaceuticals (Pvt) Ltd.
  • Droverine : Raazee Therapeutics (Pvt) Ltd.

No-spa : Available Formulations and Strengths

Presently, No-spa is available in Tablets and Injection forms

No-spa Tablets : 40mg strength

No-spa Forte Tablet : 80mg strength

No-spa Injection :40mg/2ml strength

Who Should Not Use No-spa?

As with all medications, there are certain contraindications that must be considered before using No-spa.

Hypersensitivity: No-spa should not be used in individuals who have a known hypersensitivity or allergy to the medication or any of its ingredients.

Severe hepatic impairment: No-spa is metabolized by the liver, and therefore, it should not be used in individuals with severe hepatic impairment.

Severe renal impairment: No-spa is excreted primarily through the kidneys, and therefore, it should not be used in individuals with severe renal impairment.

Glaucoma: No-spa can cause pupil dilation, which can worsen the symptoms of glaucoma. It should not be used in individuals with narrow-angle glaucoma.

Myasthenia gravis: No-spa can worsen the symptoms of myasthenia gravis, which is a neuromuscular disorder. It should be used with caution in individuals with this condition.

Cardiovascular disease: No-spa can cause vasodilation, which can lead to a drop in blood pressure. It should be used with caution in individuals with cardiovascular disease, including hypotension, angina, and arrhythmias.

What is the Recommended Daily Dosage of No-spa Tablet?

No-spa Dose for Adults: 3-6 tablets in 24 hours, divided into 2-3 doses.

No-spa Dose for Children: 1-3 tablets in 24 hours, divided into 2-3 doses

No-spa Injection Dosage:

The No-spa injection can be administrated as intramuscular, subcutaneous, or intravenous injections.

The average daily dose is 40 – 240mg (1-6 injections) within 1 – 3 divided intervals, intramuscular or subcutaneous injections of 2 – 4 ml of 2% solution each for adults and children over the age of 12 years.

How No-spa Works?

No-spa works by inhibiting the enzyme phosphodiesterase-IV (PDE-IV), which plays a role in regulating the concentration of cyclic adenosine monophosphate (cAMP) in smooth muscle cells. Resultantly, it increases cAMP concentration and decreases calcium uptake of the cells it helps to distribute calcium among the cells.

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No-spa Side Effects