Motival Tablet Uses

Motival Tablet is a medication with a combination of an antipsychotic and an antidepressant. Motival is primarily used to treat certain psychiatric conditions such as:

• Schizophrenia
• Psychotic disorders
• Depression
• Treatment-resistant depression
• Neuropathic pain

Ingredients Of Motival Tablets and Their Uses

Fluphenazine Uses:

1. Schizophrenia: Fluphenazine is primarily used for the treatment of schizophrenia, a chronic psychiatric disorder characterized by disturbances in thinking, emotions, and perception. It helps in reducing hallucinations, delusions, and other symptoms associated with this condition.
2. Psychotic Disorders: Fluphenazine may also be prescribed for other psychotic disorders, such as schizoaffective disorder or psychotic depression, to manage symptoms like hallucinations, disorganized thinking, and agitation.

Nortriptyline Uses:

1. Depression: Nortriptyline is primarily used for the treatment of depression. It is a tricyclic antidepressant (TCA) that works by increasing the levels of certain neurotransmitters in the brain, such as serotonin and norepinephrine, which help improve mood and alleviate depressive symptoms.
2. Neuropathic Pain: Nortriptyline is sometimes prescribed for the management of neuropathic pain conditions, such as diabetic neuropathy, postherpetic neuralgia (nerve pain following shingles), and other chronic pain syndromes. It can help reduce pain signals in the nervous system and provide pain relief.

Motival is one of the leading brands of Fluphenazine HCl + Nortriptyline HCl, manufactured and marketed by GlaxoSmithKline Pakistan.

Following are some alternative brands of Motival and their manufacturers.

• Modrin : Pharmedic (Pvt) Ltd, Pakistan.
• Sensival : Pharmedic (Pvt) Ltd, Pakistan.
• Motisone : Geofman Pharmaceuticals, Pakistan.
• Notrilin : Usawa Pharmaceuticals, Pakistan.

Presently, Motival is available in Tablet Form with the following strengths

Motival Tablet : Fluphenazine HCl 0.5mg + Nortriptyline HCl 10mg

The first step in safely using Motival is to understand the potential contraindications associated with it.

• Hypersensitivity: Individuals who have a known hypersensitivity or allergic reaction to any components of Motival should not use this medication.
• Glaucoma: Motival can increase intraocular pressure, which can be harmful to individuals with certain types of glaucoma. Therefore, Motival is generally contraindicated in individuals with narrow-angle glaucoma or a history of angle-closure glaucoma.
• Central nervous system depression: Motival has sedative effects on the central nervous system. As a result, Motival should be used with caution or avoided in individuals with a history of central nervous system depression, such as severe drowsiness, respiratory depression, or coma.
• Severe cardiovascular disorders: Motival may have potential risks for individuals with severe cardiovascular disorders, such as recent myocardial infarction (heart attack), heart failure, arrhythmias, or conduction disturbances. Motival should be used with caution or avoided in such cases.
• Liver impairment: Motival undergoes hepatic metabolism. Individuals with severe liver impairment may have difficulties metabolizing these medications properly, which can increase the risk of adverse effects. Dose adjustments or alternative treatment options may be necessary.

Motival Dose for Adults: 

• One tablet of 10mg twice daily.

Fluphenazines (an active ingredient of Motival): It works by blocking dopamine D2 receptors at the postsynaptic neuron and preventing the action of dopamine.

Nortriptyline (another active ingredient of Motival): It works by inhibiting the reuptake of serotonin and norepinephrine at the presynaptic neuronal membrane.

Related Links:

Motivals Side Effects