Sibelium Capsule Uses

Sibelium capsules are primarily used to prevent migraine headaches and vestibular vertigo. It belongs to a class of drugs called calcium channel blockers. Sibelium cap is also used to manage conditions related to blood vessel constriction and calcium regulation in the body. Following are some common and off-label uses of Sibelium Capsule:

Common Uses of Sibelium Capsule

1. Migraine Prophylaxis: Sibelium is most commonly used for the prevention of migraine attacks. It is effective in reducing the frequency, severity, and duration of migraines. It works by blocking calcium channels, which helps to stabilize blood vessels and prevent them from dilating excessively, which is thought to contribute to migraine attacks.
2. Vertigo and Vestibular Disorders: Sibelium may be used to manage vertigo and various vestibular disorders, including Meniere’s disease. It helps to reduce the intensity and frequency of vertigo episodes through its calcium channel-blocking properties, which affect the vestibular system.
3. Prophylaxis of Basilar Migraine: Sibelium is sometimes prescribed for the prophylactic treatment of basilar-type migraine, which is characterized by symptoms originating from the brainstem or basilar artery. It can help in reducing the frequency and severity of the associated symptoms, such as headache, dizziness, visual disturbances, and difficulty with coordination.
4. Prophylaxis of Hemiplegic Migraine: Sibelium may be used for the prevention of hemiplegic migraine, a rare and severe form of migraine that causes temporary paralysis or weakness on one side of the body. It can help reduce the frequency and severity of hemiplegic migraine attacks.

Off-label Uses of Sibelium Capsule

1. Essential Tremor: Sibelium has been used off-label in the treatment of essential tremor, a neurological disorder characterized by involuntary shaking movements. It may help reduce the severity and frequency of tremors in some individuals, although the evidence supporting its use for this indication is limited.
2. Tinnitus: Sibelium has been explored as a potential treatment for tinnitus, a condition characterized by the perception of ringing or noise in the ears. It may help alleviate symptoms in some individuals, possibly by its effects on calcium channels and neuronal excitability.

Sibelium is one of the leading brands of Flunarizine (HCl), manufactured and marketed by Janssen-Cilag.

The Following are some available similar brands that can be used as an alternative to Sibelium Cap:

• Migram : Amarant Pharmaceuticals (Pvt) Ltd, Pakistan.
• Luner : Saffron Pharmaceuticals (Pvt) Ltd, Pakistan.
• Flunazic : Panacea Pharmaceuticals, Pakistan.
• Polyzine : Polyfine Chempharma (Pvt) Ltd, Pakistan.

Presently, Sibelium is available in Capsule Form with the following strength.

Sibelium Capsule : 5mg strength.

Sibelium has several contraindications, which are specific situations or conditions where the use of Sibelium is not recommended due to the potential risks outweighing the potential benefits.

• Hypersensitivity: Sibelium is contraindicated in individuals who have a known hypersensitivity or allergy to the medication or any of its components. Signs of hypersensitivity may include rash, itching, swelling, severe dizziness, or difficulty breathing.
• Parkinson’s Disease: Sibelium is contraindicated in individuals with Parkinson’s disease or those with Parkinsonian symptoms due to the potential to worsen these conditions. Flunarizine may have extrapyramidal side effects that resemble parkinsonian symptoms.
• Depressive Disorders: Sibelium is contraindicated in individuals with current or previous depressive disorders due to the potential to worsen depression or induce suicidal thoughts. It may have central nervous system depressant effects.
• History of Extrapyramidal Disorders: Sibelium is contraindicated in individuals with a history of extrapyramidal disorders or movement disorders such as tardive dyskinesia or dystonia, as it may worsen these conditions or induce movement abnormalities.
• Severe Renal or Hepatic Impairment: Sibelium should be used with caution or avoided in individuals with severe renal impairment (kidney dysfunction) or severe hepatic impairment (liver dysfunction) as its metabolism and elimination may be affected. Dose adjustment may be required in individuals with milder impairments.

Sibelium Dose for Migraine Prophylaxis:

• 1 to 2 Capsules of 5mg, once daily at bedtime.
• The starting dose is often 5mg, and it can be increased to 10mg if necessary.

Sibelium Dose for Off-label Uses, (Vestibular Migraine or Essential Tremor):

• The daily dose of Sibelium may vary. It is important to consult with a healthcare professional for specific dosing instructions tailored to the individual condition and patient characteristics.

Sibelium works by blocking voltage-gated calcium channels, particularly L-type calcium channels, in various tissues and cells. By inhibiting the entry of calcium ions into cells, it reduces calcium-dependent processes and modulates cellular functions. It results in the relaxation and dilation of blood vessels, particularly the cerebral and peripheral arteries. This vasodilatory effect helps to improve blood flow and reduce vascular spasms, which may contribute to the prevention of migraines.

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