Neogab Capsule Uses

Neogab capsule is a medication primarily used to treat certain types of seizures (epilepsy) and to relieve nerve pain. Following are some common and off-label uses of Neogab Capsules:

Common Uses of Neogab Capsule

1. Epilepsy: Neogab is a commonly used medication for epilepsy management. It is primarily used as an adjunctive (additional) treatment for partial seizures, including both focal seizures and focal-to-bilateral tonic-clonic seizures is used as an adjunctive (additional) treatment for
2. Postherpetic Neuralgia (PHN): Neogab is used for the management of postherpetic neuralgia, which is nerve pain that occurs after an outbreak of shingles (herpes zoster).
3. Neuropathic Pain: Neogab is also used for the treatment of neuropathic pain associated with diabetic peripheral neuropathy.
4. Fibromyalgia: Neogab is used for the management of fibromyalgia, a chronic disorder characterized by widespread musculoskeletal pain and other associated symptoms.
5. Restless Legs Syndrome (RLS): Neogab capsule is a prodrug that is also used for the treatment of moderate to severe primary RLS in adults.

Off-label Uses of Neogab Capsule

1. Other Neuropathic Pain: In addition to diabetic peripheral neuropathy, Neogab is frequently used off-label for other types of neuropathic pain, such as post-surgical neuropathy, nerve pain related to spinal cord injury, and trigeminal neuralgia.
2. Migraine Prevention: Neogab may be used off-label as a preventive medication for migraines, especially in individuals who experience frequent or chronic migraines.
3. Anxiety Disorders: Neogab is sometimes used for anxiety disorders, including generalized anxiety disorder (GAD), social anxiety disorder, and panic disorder. It may be used as an adjunctive treatment or alternative to other medications for anxiety.
4. Insomnia: Neogab is occasionally used off-label to aid with sleep and manage insomnia, particularly in individuals who experience difficulty falling asleep or have sleep disturbances due to pain or restless legs syndrome (RLS).
5. Bipolar Disorder: Neogab may be used as an adjunctive treatment for bipolar disorder to help stabilize mood and manage associated symptoms, such as anxiety or neuropathic pain.
6. Alcohol Withdrawal: Neogab may be used to manage symptoms of alcohol withdrawal, such as anxiety, tremors, and insomnia.

Neogab is one of the leading brands of Gabapentin, manufactured and marketed by Hilton Pharmaceuticals (Pvt) Ltd, Pakistan.

Below are some available similar brands that can be used as an alternative to Neogab:

• Gabix : Getz Pharmaceuticals (Pvt) Ltd, Pakistan.
• Gaba : Nabiqasim Industries (Pvt) Ltd, Pakistan.
• Neopentine : Highnoon Laboratories Ltd, Pakistan.
• Abapen : Bosch Pharmaceuticals (Pvt) Ltd, Pakistan.
• Duogab : Searle (Paksitan) Ltd.
• Gabafix : S.J. & G. Fazul Ellahie (Pvt) Ltd, Pakistan.
• Bapen : Genetic Pharmaceuticals, Pakistan.
• Gepent : Amarant Pharmaceuticals (Pvt) Ltd, Pakistan.
• Nervex : Standpharm Pakistan (Pvt) Ltd, Pakistan.
• Gabavant : Avant Pharmaceuticals (Pvt) Ltd, Pakistan.

Presently, Neogab is available in Capsule Form with the following strengths.

Neogab Capsules : 100mg, 300mg, and 400mg strengths

Neogab has some contraindications, which are specific situations or conditions in which the use of Neogab is not recommended.

1. Hypersensitivity: Neogab is contraindicated in individuals who have a known hypersensitivity or allergy to Neogab or any of its components. If you have experienced an allergic reaction to Neogab in the past, it’s important to inform your healthcare provider.
2. Renal impairment: Neogab is primarily eliminated from the body through the kidneys. Therefore, individuals with severe renal impairment or those undergoing dialysis may require dosage adjustments or should avoid Neogab use altogether. Your healthcare provider will assess your kidney function and determine the appropriate dose if you have any renal issues.
3. Respiratory depression: Neogab can cause respiratory depression, particularly when combined with other medications that have a similar effect, such as opioids. Therefore, Neogab should be used with caution or avoided in individuals with respiratory depression or compromised respiratory function.
4. Pre-existing psychiatric conditions: Neogab may exacerbate certain psychiatric conditions, such as depression and suicidal ideation. It is important to use Neogab cautiously and under close supervision in individuals with pre-existing psychiatric disorders.
5. Pregnancy and breast-feeding: The use of Neogab during pregnancy and breastfeeding may have potential risks, and its use should be carefully considered in these situations.

Neogab Dose for Epilepsy:

• Adults and Adolescents (12 years and older): One capsule of 300mg, three times a day.
• The dose may be titrated up gradually as needed to a maximum dose of 3600mg per day.
• Children (3-11 years): The dose is based on body weight and typically ranges from 10-15 mg/kg/day, divided into three doses.

Neogab Dose for Postherpetic Neuralgia (PHN):

• Initial Dose: One Capsule of 300mg, on day one.
• One capsule of 300mg twice daily on day two
• One capsule of 300mg three times daily on day three.
• The dose may be titrated up as needed to a maximum dose of 1800 mg per day.

Neogab Dose for Restless Legs Syndrome (RLS):

• Two Capsules of 300mg, once daily, administered in the evening.

Neogab Dose for Neuropathic Pain and Other Off-label Uses:

• Starting dose: One Capsule of 300mg, once daily.
• The dose may be increased gradually based on response and tolerability, up to a maximum dose of 3600 mg per day.

Neogab works by binding to the α2δ-1 subunit of voltage-gated calcium channels, which are involved in the release of certain neurotransmitters. By binding to this subunit, Neogab may reduce the release of excitatory neurotransmitters such as glutamate, norepinephrine, and substance P. This modulation of calcium channels may contribute to the antiepileptic and analgesic effects of Neogab.

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Neogab Side Effects