GTN Cream Uses

GTN cream is used for the treatment of specific conditions related to anal fissures and hemorrhoids. Anal fissures and hemorrhoids are two discomforting concerns that can significantly impact one’s quality of life. These conditions can cause pain, discomfort, and embarrassment, making it crucial to seek effective remedies. GTN cream is a topical treatment that is utilized to alleviate symptoms and promote healing.

About GTN Cream

• Generic Name: Glyceryl Trinitrate + Xylocaine
• Properties: Vasodilator + Local Anaesthetic
• Manufactured and Marketed By: Fazal Din & Sons
• Presentation: 25gm Tube (Cream form)

1. Anal Fissures: Anal fissures are small tears or cracks in the lining of the anus, which can be extremely painful and often occur during bowel movements. GTN cream is used to treat anal fissures by relaxing the smooth muscle in the anal sphincter and increasing blood flow to the area. This helps reduce pain and promotes healing by improving the oxygen supply to the injured tissue. The cream is typically applied to the anal area and may be used for a few weeks as part of the treatment plan.
2. Hemorrhoids: Hemorrhoids are swollen blood vessels in the rectal or anal area that can cause pain, itching, and discomfort. GTN cream can also be used to treat hemorrhoids, as it has a similar effect of relaxing blood vessels and reducing pain and discomfort associated with hemorrhoidal inflammation. It can help relieve symptoms and promote healing of hemorrhoids when applied topically.

Ingredients and Formulation

• Glyceryl trinitrate: 0.2%
• Lignocaine/Lidocaine (xylocaine): 5%

Benefits of Using GTN Anal Fissure & Hemorrhoid Cream

Using GTN cream can offer several advantages:

• Pain Relief: It helps alleviate the pain associated with anal fissures and hemorrhoids, making daily life more comfortable.
• Promotes Healing: The cream aids in the healing process, reducing the duration and severity of these conditions.
• Decreases Inflammation: GTN cream can reduce the swelling and inflammation of hemorrhoids.

How to Properly Apply GTN Cream

1. Wash Your Hands: Begin by thoroughly washing your hands with soap and water. This ensures that the area remains clean during the application process.
2. Clean the Affected Area: Gently clean the anal and perianal area with mild soap and water or use a moistened, unscented baby wipes. Pat the area dry with a soft, clean cloth or tissue. Avoid using rough toilet paper, as it may irritate the area.
3. Positioning: Find a comfortable and private place to apply the cream. Some people prefer to lie down on their side with their knees bent to access the anal area more easily. Alternatively, you can assume a squatting or crouching position if that’s more comfortable.
4. Application: Here’s how to apply GTN cream:
   • Squeeze a small amount of GTN cream onto your fingertip or onto a clean cotton swab.
   • Gently and carefully apply the cream to the affected area, whether it’s an anal fissure or hemorrhoids. Use a gentle, circular motion to spread the cream evenly over the area. Be cautious not to insert the cream into the rectum; it should be applied externally to the skin or mucous membranes around the anus.
   • It’s crucial to use only the amount prescribed by your healthcare provider. Applying too much cream can lead to excessive absorption and potential side effects.
5. Wash Hands Again: After application, wash your hands thoroughly to remove any residual cream and prevent accidental contact with sensitive areas or mucous membranes.
6. Frequency: Follow the specific instructions provided by your healthcare provider regarding how often to apply the GTN cream. Typically, it is applied two to three times a day or as prescribed.
7. Storage: Store the GTN cream according to the manufacturer’s instructions, typically at room temperature away from direct sunlight and moisture.
8. Follow Prescribed Duration: Use the GTN cream for the prescribed duration, even if your symptoms improve. Stopping the treatment prematurely can lead to a recurrence of the condition.
9. Avoid Contact with Eyes and Mouth: Be very cautious not to get GTN cream on your face, especially in the eyes or mouth. If accidental contact occurs, rinse with plenty of water immediately and seek medical attention if needed.

Who Should Avoid Using GTN Cream? – Contraindications

1. Allergy or Hypersensitivity: If you are known to have a hypersensitivity or allergy to glyceryl trinitrate or any of the components in the cream, you should not use it. Allergic reactions can range from mild skin irritation to severe allergic responses.
2. Severe Anemia: GTN can cause a drop in blood pressure, which may worsen anemia (a condition characterized by a low red blood cell count and reduced oxygen-carrying capacity of the blood). It’s essential to consult with your healthcare provider if you have severe anemia before using GTN cream.
3. Use of Phosphodiesterase-5 (PDE-5) Inhibitors: The concurrent use of GTN and PDE-5 inhibitors, such as sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra), can lead to a significant drop in blood pressure, potentially resulting in serious health complications. Avoid using GTN cream if you are taking PDE-5 inhibitors for erectile dysfunction or pulmonary arterial hypertension. Consult your healthcare provider for guidance on timing and safety.
4. Closed-Angle Glaucoma: GTN can cause eye-related side effects, and if you have a history of closed-angle glaucoma, a condition characterized by increased pressure in the eye, using GTN cream near the eyes should be avoided.
5. Head Trauma: GTN may increase intracranial pressure, and its use is generally contraindicated in cases of recent head trauma or increased intracranial pressure.
6. Hypotension (Low Blood Pressure): If you have hypotension, which is characterized by abnormally low blood pressure, the use of GTN cream may further lower blood pressure, potentially causing fainting or dizziness.
7. Use of Riociguat: Riociguat is a medication used for pulmonary arterial hypertension. Combining it with GTN cream can lead to a significant drop in blood pressure and should be avoided.
8. Pregnancy and Breastfeeding: The use of GTN cream during pregnancy or breastfeeding should be carefully considered, and its benefits should outweigh the potential risks. Consult with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.

FAQs

Q1: How fast can I expect results with GTN cream?
A1: Results may vary, but many individuals experience relief within a few days of using GTN cream regularly.

Q2: Can I purchase GTN cream over the counter?
A2: GTN cream is typically available by prescription, so consult your healthcare provider for guidance.

Q3: Are there any dietary recommendations while using GTN cream?
A3: While using GTN cream, it’s advisable to maintain a healthy, fiber-rich diet to aid in bowel regularity.

Q4: Can GTN cream be used for children?
A4: GTN cream is generally not recommended for children without a doctor’s guidance.

Q5: Is GTN cream a long-term solution for anal fissures and hemorrhoids?
A5: GTN cream can be used as a short-term solution to alleviate symptoms. However, it’s essential to address the underlying causes of these conditions for long-term relief.

The following brands (cream) are not similar in composition to GTN cream But can be used as an alternative to treat Anal fissures & hemorrhoids.

Tronolane : Abbott Laboratories (Pakistan) Ltd.

Posterisan Forte : AGP (Pvt) Ltd, Pakistan.