Sulvorid Side Effects

Sulvorid is a medication that is primarily used to treat various gastrointestinal and psychiatric conditions. Like all medications, it can have side effects. Here are some common and less common side effects associated with Sulvorid.

Common Side Effects:

• Extrapyramidal Symptoms (EPS): These can include symptoms like tremors, muscle stiffness, muscle spasms, and restlessness. EPS is more likely to occur at higher doses.
• Hyperprolactinemia: Sulvorid can lead to an increase in prolactin levels, a hormone that regulates breast milk production. This can result in symptoms such as breast tenderness, breast enlargement, and disruptions in menstrual periods.
• Gastrointestinal Disturbances: Common side effects of Sulvorid may include diarrhea, constipation, and abdominal pain.
• Weight Gain: Some individuals may experience weight gain while taking Sulvorid.
• Sedation: Sulvorid can cause drowsiness and may affect alertness and concentration.
• Anxiety and Agitation: Taking Sulvorid some people may experience increased anxiety or agitation as a side effect.
• Dry Mouth: Dry mouth is a common side effect of Sulvorid and can be managed by staying well-hydrated and using sugar-free gum or lozenges.

Less Common Side Effects:

• Neuroleptic Malignant Syndrome (NMS): Although rare, Sulvorid can lead to NMS, a potentially life-threatening condition characterized by symptoms like high fever, muscle rigidity, altered mental status, and autonomic dysfunction. NMS requires immediate medical attention.
• Cardiovascular Effects: Sulvorid can occasionally lead to changes in heart rate and blood pressure. It should be used cautiously in individuals with preexisting heart conditions.
• Allergic Reactions: While taking Sulvorid rare, allergic reactions can occur, with symptoms such as rash, itching, swelling of the face or throat, and difficulty breathing. Seek immediate medical attention if you experience these symptoms.
• Liver Function Abnormalities: Sulvorid can affect liver function in rare cases, leading to jaundice (yellowing of the skin and eyes) and other liver-related symptoms.
• Blood Disorders: Sulvorid can rarely affect blood cell counts, leading to conditions like leukopenia (low white blood cell count) or thrombocytopenia (low platelet count).
• Hormonal Disturbances: In rare instances, Sulvorid may cause changes in other hormones aside from prolactin, potentially leading to menstrual irregularities or sexual dysfunction.

Sulvorid is one of the leading brands of Levosulpride, manufactured and marketed by High-Q Pharmaceuticals. Pakistan.

Presently, Sulvorid is available in tablet form

Sulvorid Tablets : 25mg and 50mg strengths

1. Dopaminergic Medications: Sulvorid primarily affects dopamine receptors, and its effects can be altered when combined with other dopaminergic medications, such as antipsychotics and anti-Parkinson’s drugs. The combination may lead to an increased risk of extrapyramidal symptoms (EPS).
2. Metoclopramide: Both Sulvorid and metoclopramide are prokinetic drugs used to treat gastrointestinal conditions. Combining these medications may result in additive effects on gastrointestinal motility, leading to an increased risk of side effects like EPS.
3. Alcohol: Alcohol may enhance the sedative effects of Sulvorid. This can lead to increased drowsiness and impaired coordination.
4. Sedatives and Central Nervous System Depressants: Sulvorid can enhance the sedative effects of drugs like benzodiazepines, opioids, and certain sleep medications, leading to increased drowsiness and impaired alertness.
5. Medications that Affect Prolactin Levels: Sulvorid increases prolactin levels, so combining it with other medications that have similar effects (e.g., antipsychotics) can lead to even higher levels of prolactin and an increased risk of hyperprolactinemia-related symptoms.
6. Antidepressants: Combining Sulvorid with certain antidepressants, particularly those that affect serotonin levels (e.g., selective serotonin reuptake inhibitors or SSRIs), can increase the risk of serotonin syndrome, a potentially life-threatening condition characterized by symptoms like agitation, confusion, rapid heart rate, and high blood pressure.
7. Antipsychotic Medications: Combining Sulvorid with other antipsychotic drugs may lead to additive effects on dopamine receptors and increase the risk of side effects, including EPS.
8. Anticholinergic Drugs: Sulvorid can have anticholinergic effects, and combining it with other medications with anticholinergic properties can lead to an increased risk of side effects such as dry mouth, blurred vision, and constipation.
9. Hypotensive Medications: Sulvorid may affect blood pressure, so combining it with other medications that lower blood pressure can enhance the hypotensive effect.
10. Thyroid Medications: Sulvorid may interfere with the absorption and efficacy of thyroid medications. Dosage adjustments may be necessary.