Celbex Side Effects

Celbex is a medication primarily used to relieve pain and inflammation in conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. It belongs to a class of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs). While it can be effective in managing pain and inflammation, like all medications, Celbex may have side effects. Below are some common and less common side effects associated with Celbex.

Common Side Effects

Gastrointestinal Issues: NSAIDs, including Celbex, can irritate the stomach lining, potentially leading to:

1. Abdominal pain
2. Indigestion
3. Nausea
4. Diarrhea
5. Gastric ulcers or bleeding (less common but can be severe)

Cardiovascular Effects: Celbex may slightly increase the risk of heart-related events such as heart attack or stroke, especially in people with pre-existing cardiovascular conditions. This risk appears to be lower than some other NSAIDs, but it is still a concern.

Fluid Retention: Some individuals may experience fluid retention, leading to swelling in the legs or ankles.

Less Common Side Effects

• Allergic Reactions: In rare cases, Celbex can cause allergic reactions, which may include hives, rash, itching, swelling of the face or throat, and difficulty breathing. Seek immediate medical attention if you experience these symptoms.
• Liver Problems: While uncommon, Celbex may affect liver function. Symptoms of liver problems can include jaundice (yellowing of the skin or eyes), dark urine, and abdominal pain.
• Kidney Issues: NSAIDs like Celbex can affect kidney function. Symptoms of kidney problems include changes in urine color or volume and swelling in the hands or feet.
• High Blood Pressure: Some individuals may experience an increase in blood pressure while taking Celbex.
• Blood Disorders: In rare cases, Celbex may affect blood cells, potentially leading to anemia or a decrease in blood platelets.

Celbex is one of the leading brands of Celecoxib, manufactured and marketed by Getz Pharmaceuticals, Pakistan.

Presently, Celbex is available in Capsules form

Celbex Capsules : 100mg, and 200mg strengths

Celbex Plus Capsule : 400mg strength

Other NSAIDs: Combining Celbex with other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen, or aspirin can increase the risk of gastrointestinal side effects and may also heighten the risk of cardiovascular events. It’s generally not recommended to use multiple NSAIDs concurrently.

Anticoagulants (Blood Thinners): Celbex may increase the risk of bleeding when taken alongside anticoagulant medications like warfarin or antiplatelet drugs like clopidogrel. Close monitoring of blood clotting parameters is advisable if these medications are used together.

Corticosteroids: Combining Celbex with corticosteroids, such as prednisone, can increase the risk of gastrointestinal ulcers and bleeding.

ACE Inhibitors and Diuretics: Celbex may reduce the effectiveness of certain blood pressure medications like ACE inhibitors and diuretics. Blood pressure should be closely monitored if these drugs are used together.

Lithium: Celbex may increase the blood levels of lithium, which is used to treat bipolar disorder. This can potentially lead to lithium toxicity, so monitoring lithium levels and adjusting the dose may be necessary when combining these medications.

Methotrexate: Celbex may increase the levels of methotrexate in the blood, potentially increasing the risk of methotrexate-related side effects. Close monitoring is advised if these medications are used together.

Cyclosporine: Combining Celbex with cyclosporine, an immunosuppressant medication, may increase the risk of kidney problems. Kidney function should be monitored closely in individuals taking these medications simultaneously.

Selective Serotonin Reuptake Inhibitors (SSRIs): Combining Celbex with SSRIs, a class of antidepressants, may increase the risk of bleeding. Close monitoring is recommended.

Alcohol: Consuming alcohol while taking Celbex can increase the risk of gastrointestinal side effects and bleeding. It’s generally advisable to limit or avoid alcohol consumption while on this medication.

Herbal Supplements: Certain herbal supplements, such as ginkgo biloba and garlic, may increase the risk of bleeding when used with Celbex.