Siroline Syrup Uses

Siroline syrup is used to relieve symptoms associated with respiratory conditions, such as cough, congestion, and difficulty breathing. It has a bronchodilator and expectorant properties that relax the muscles in the airways, reducing inflammation, and thinning mucus. Siroline Syrup is also used to treat COPD (Chronic Obstructive Pulmonary Disease) including emphysema and chronic bronchitis. Following are some approved and off-label uses of Siroline Syrup:

Approved Uses of Siroline Syrup

1. Cough: Siroline syrup is used for the relief of cough, particularly when the cough is associated with conditions like the common cold, respiratory infections, or bronchitis. The components of Siroline syrup work together to help suppress cough and alleviate irritation in the airways.
2. Congestion: Using Siroline syrup can help relieve congestion by dilating the airways, reducing inflammation, and thinning mucus. This can make it easier to breathe and alleviate the sensation of congestion.
3. Bronchospasm: Siroline has bronchodilator properties that can help relax and open up the airways, making it useful in conditions characterized by bronchospasm, such as asthma or chronic obstructive pulmonary disease (COPD).
4. Expectorant: The use of Siroline syrup provides expectorant effects, that help to thin and loosen mucus in the respiratory tract. It can also facilitate the removal of mucus and phlegm through coughing.
5. Throat Irritation: Siroline has a soothing effect on the throat and airways, providing relief from irritation and discomfort.

Off-label Uses of Siroline Syrup

1. Asthma: While the components of Siroline syrup individually have mechanisms that might benefit individuals with asthma (such as bronchodilation and reducing inflammation), this combination could potentially be explored for symptom relief. However, asthma management usually involves a comprehensive treatment plan, so any off-label use should be carefully considered and monitored by a healthcare professional.
2. Respiratory Infections: Siroline syrup’s components may provide relief from cough and congestion associated with respiratory infections like bronchitis. It might help manage symptoms while the body fights off the infection.
3. Allergic Reactions: The antihistamine diphenhydramine in Siroline syrup could potentially help manage symptoms of allergic reactions, such as itching, hives, or skin rash. This might be considered in cases where other antihistamines are not suitable.
4. Chronic Obstructive Pulmonary Disease (COPD): Similar to asthma, COPD involves airflow limitation and respiratory symptoms. The bronchodilator and other properties of Siroline syrup could be considered for symptom management under medical supervision.
5. Upper Respiratory Tract Inflammation: The soothing and expectorant properties of Siroline syrup might be explored for managing inflammation and irritation in the upper respiratory tract.

Siroline is one of the leading brands of cough syrup with the combination of Theophylline + Diphenhydramine + Ammonium Chloride + Menthol, manufactured and marketed by Chas. A Mendoza.

Alternative brands with a similar composition to Siroline Syrup:

• Cofrest : W.Woodward Pakistan (Pvt) Ltd.
• Carol : Ideal Pharmaceutical Industries, Pakistan.

Alternative brands, that are not similar in composition but can used as an alternative to Siroline Syrup.

• Acefyl Syrup : Nabiqasim Industries (Pvt) Ltd, Pakistan.
• Hydryllin Syrup : Searle Pakistan (Pvt) Ltd.
• Corex D Syrup : Pfizer Laboratories Inc.
• Reltus DM Syrup : Pharmatec Pakistan (Pvt) Ltd.
• Combinol D Syrup : Atco Laboratories Ltd, Pakistan.
• Bronochol Syrup : Ferozsons Laboratories Ltd, Pakistan.
• Cosome-E Syrup : Martin Dow Marker (Pvt) Ltd, Pakistan.
• Actifed DM Syrup : GlaxoSmithKline (GSK).
• Adicos : Zafa Pharmaceutical Laboratories (Pvt) Ltd, Pakistan.

Presently, Siroline is available in Syrup form only.

Siroline Syrup Each 5ml Contains:

• Theophylline: 32mg
• Diphenhydramine: 8mg
• Ammonium Chloride: 30mg
• Menthol: 0.98mg

Siroline syrup may have specific contraindications and precautions that individuals should be aware of. Contraindications are situations in which the use of a Siroline Syrup is not recommended due to potential risks.

1. Hypersensitivity or Allergy: If you are known to be hypersensitive or allergic to any of the active ingredients (theophylline, diphenhydramine, ammonium chloride, or menthol) or other components of Siroline syrup, you should avoid its use.
2. Severe Respiratory Conditions: Siroline Syrup is a bronchodilator that affects the respiratory system. Individuals with certain respiratory conditions, especially uncontrolled asthma or other severe lung diseases, should use Siroline with caution and under medical supervision.
3. Seizure Disorders: Siroline Syrup might lower the seizure threshold in some individuals, so those with a history of seizure disorders should use this syrup with caution and medical guidance.
4. Heart Conditions: Siroline syrup can affect heart rate and rhythm. Individuals with certain heart conditions, such as arrhythmias or heart failure, should use it under medical supervision.
5. Hypertension (High Blood Pressure): Theophylline an active ingredient of Siroline syrup can potentially affect blood pressure. Individuals with uncontrolled hypertension or certain cardiovascular conditions should be cautious when using this syrup.
6. Gastrointestinal Ulcers: Siroline contains ammonium chloride that might increase stomach acid production, potentially exacerbating gastrointestinal ulcers or conditions like gastroesophageal reflux disease (GERD).
7. Liver or Kidney Impairment: Some ingredients of Siroline syrup are metabolized in the liver and excreted by the kidneys. Individuals with liver or kidney impairment may need dosage adjustments or careful monitoring.
8. Elderly Patients: Older adults may be more susceptible to certain side effects, such as dizziness or drowsiness, and should use Siroline syrup with caution.
9. Alcohol and Sedatives: Siroline Syrup also contains Menthol and Diphenhydramine which might enhance the sedative effects of alcohol and other central nervous system depressants.
10. Medication Interactions: Ingredients of Siroline syrup can interact with various medications, including other bronchodilators, antihistamines, and certain antidepressants. Inform your healthcare provider about all medications you are taking.
11. Pregnancy and Breastfeeding: The safety of Siroline syrup during pregnancy and breastfeeding may not be well-established. Consult a healthcare provider before using.

Siroline Syrup Dose for Adults:

• 1-2 teaspoonsful 2-3 times daily.

Siroline Syrup Dose for Children 6 to 12 years old:

• 1 teaspoonful of syrup 2-3 times daily.

Siroline Syrup Dose for Children 3 to 6 years old:

• 1/2 teaspoonful of syrup 2-3 times daily.

Siroline syrup is a combination of four ingredients and each ingredient contributes to different aspects of symptom management:

1. Theophylline:
   • Bronchodilation: Theophylline is a bronchodilator that relaxes the smooth muscles of the airways in the lungs. This action helps to widen the air passages, making it easier to breathe and improving airflow. It can be particularly beneficial for conditions involving bronchoconstriction, such as asthma or chronic obstructive pulmonary disease (COPD).
2. Diphenhydramine:
   • Antihistamine Effect: Diphenhydramine is an antihistamine that blocks the effects of histamine, a chemical released during allergic reactions. By reducing histamine’s effects, diphenhydramine can help alleviate symptoms like itching, runny nose, and sneezing.
3. Ammonium Chloride:
   • Expectorant: Ammonium chloride acts as an expectorant by thinning and loosening mucus in the airways. This helps facilitate the removal of mucus and phlegm through coughing. It can be especially useful for conditions involving excessive mucus production and congestion.
4. Menthol:
   • Soothing Effect: Menthol has a cooling and soothing effect on the respiratory tract. It can help relieve throat irritation and discomfort, making it easier to breathe and reducing the urge to cough.