Provas Injection Uses

Provas Injection has multiple uses and a wide range of therapeutic indications. We strongly recommend that no one should use Provas Injections without consulting a qualified healthcare professional. Provas in Injectable form is used for the precise delivery of medication directly into the bloodstream or targeted body tissues. This not only ensures rapid action but also reduces the risk of side effects often associated with oral medications.

The following are some common uses and indications of Provas Injection

1. Pain Relief: Provas injection can be used to relieve moderate to severe pain, such as postoperative pain, pain associated with medical procedures, or pain due to injuries.
2. Fever Reduction: It is effective in lowering high fevers, particularly in cases where oral administration is not possible, such as in patients who are unconscious or unable to swallow.
3. Emergency Situations: In emergency and critical care settings, Provas injection may be administered to quickly address fever and pain, particularly when the patient’s condition necessitates intravenous therapy.
4. Post-Surgery Pain Management: After certain surgical procedures, healthcare providers may use Provas injection to help manage pain and discomfort.
5. Pediatric Use: In pediatric patients, Provas injection may be utilized when the child is unable to take oral medication due to vomiting or other conditions.
6. Patients with Swallowing Difficulties: Some patients, particularly those with certain medical conditions or after certain surgeries, may have difficulty swallowing pills or liquids. In such cases, a Provas injection can be used.

Off-label Uses of Provas Injection

1. Migraine Headaches: Some healthcare providers may use Provas injection to help alleviate severe migraine headaches when other treatments are ineffective or contraindicated.
2. Neonatal Pain Management: Provas injection may be used off-label in neonatal intensive care units (NICUs) to manage pain in premature infants undergoing medical procedures or experiencing pain.
3. Chronic Pain: In certain cases of chronic pain conditions, Provas injection may be considered when oral medications are not effective, or when rapid pain relief is required.
4. Pain Control in Palliative Care: Provas injection might be used to help manage pain in patients with terminal illnesses or in palliative care settings.
5. Postoperative Shivering: In some cases, Provas injection has been used to treat postoperative shivering or rigors.
6. Combination Therapy: Provas injection may be combined with other medications in the management of various medical conditions, such as in the treatment of infections or inflammatory disorders.
7. Non-Operative Orthopedic Injuries: In some cases, Provas injection may be used for the management of acute non-operative orthopedic injuries to provide pain relief and reduce inflammation.
8. Fever in Critical Care: In critical care settings, Provas injection may be used off-label to control fever in patients with severe infections or other critical conditions.

Provas Injection is one of the leading brands of Paracetamol, manufactured and marketed by Sami Pharmaceuticals (Pvt) Ltd, Pakistan.

The following are Some alternative brands of Provas and their manufacturers.

• Bofalgan : Bosch Pharmaceuticals (Pvt) Ltd, Pakistan.
• Carapol : Caraway Pharmaceuticals, Pakistan.
• Detamol : Webros Pharmaceuticals, Pakistan.
• Fevenor : Global Pharmaceuticals, Pakistan.
• Ipramol : Ipram International.
• Pyramol : EG Pharmaceuticals, Pakistan.

Presently, Provas is available in Injection and Infusion forms.

Provas Injection (2ml): Paracetamol 150mg/ml strength.

Provas Infusion (100ml) : Paracetamol 1gm/100ml strength.

Provas N Tablet : Paracetamol 450mg, Orphenadrine Citrate 35mg strengths

Provas N Forte Tablet : Paracetamol 650mg, Orphenadrine Citrate 50mg strengths

Provas injection, like any medication, has specific contraindications, which are conditions or circumstances under which its use should be avoided due to potential risks or adverse effects.

1. Allergy or Hypersensitivity: Individuals who have a known allergy or hypersensitivity to Paracetamol should not receive Provas injections.
2. Severe Liver Disease: Provas is metabolized in the liver, and in cases of severe liver disease or liver failure, using Provas, particularly in high doses, can exacerbate the condition.
3. Alcohol Abuse or Chronic Alcoholism: Chronic alcohol consumption may increase the risk of liver damage when taking Provas, even at regular doses.
4. G6PD Deficiency: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a genetic condition that can lead to hemolytic anemia when exposed to certain substances, including some medications. Provas can trigger hemolysis in individuals with G6PD deficiency.
5. Certain Blood Disorders: Conditions like methemoglobinemia can be exacerbated by Provas, so it may be contraindicated in these cases.
6. Malnutrition or Fasting: In situations of malnutrition or fasting, the liver’s ability to process Provas may be compromised, potentially leading to toxicity.
7. Pregnancy and Breastfeeding: While Provas is generally considered safe during pregnancy and breastfeeding when taken in recommended doses, high doses or prolonged use should be avoided without medical supervision.
8. Kidney Disease: Although Provas is primarily metabolized in the liver, it can affect the kidneys indirectly. In cases of severe kidney disease, the use of Provas may need to be adjusted.
9. Severe Dehydration: In cases of severe dehydration, especially when it leads to impaired kidney function, the use of Provas may need to be evaluated and adjusted.
10. Certain Medications: There can be interactions with other medications, particularly those that affect liver function or are metabolized in a similar way. It’s important to consult a healthcare provider if taking multiple medications.

Provas Injection Dosage for Adults and Adolescents (12 years and older):

• Single Dose: 1gm (One Infusion of Provas 100ml), administered intravenously.
• Frequency: This dosage may be repeated every 4 to 6 hours as needed, but it’s important not to exceed the maximum daily dose, typically 4 grams (4000 mg), to avoid the risk of overdose and potential liver damage.

Provas Injection Dosage for Children (1 month to 11 years):

• Single Dose: The dose is based on the child’s weight. A common dosage is 15 mg/kg, with a maximum dose of 1 gram (1000 mg) per dose.
• Frequency: This dosage may be repeated every 4 to 6 hours as needed, but the total daily dose should not exceed the recommended maximum for the child’s weight.

Provas Injection Dosage for Infants (0 to 1 month):

• Single Dose: The dose is also based on weight. In neonates, a common dosage is 7.5 to 15 mg/kg, with a maximum dose of 500 mg per dose.
• Frequency: The dosing interval may vary depending on the specific clinical situation, but it’s important to adhere to the recommended dosing schedule provided by a healthcare provider.

Administration

• Intravenous (IV) Administration: Provas injection should be administered by a healthcare professional in a clinical setting. It is typically given slowly over a period of 15 minutes to an hour.
• Dilution: The injection is usually diluted before administration. The specific dilution and infusion rate will be determined by the healthcare provider based on the patient’s age, weight, and clinical condition.
• Monitoring: The patient’s vital signs, liver function, and overall response to the medication should be monitored during and after administration.
• Adherence to Aseptic Technique: Standard aseptic technique should be followed during the preparation and administration of the injection to minimize the risk of infection.
• Storage: Provas injections should be stored as directed by the manufacturer and should be checked for any signs of deterioration before use.

Pain Reduction: Provas is thought to work by inhibiting the production of certain chemicals called prostaglandins in the brain and spinal cord. Prostaglandins play a role in transmitting pain signals, causing inflammation, and regulating body temperature. By reducing the production of these prostaglandins, Provas helps to lower pain sensitivity, making you feel less pain.

Fever Reduction: Provas helps lower fever by acting on the brain’s hypothalamus, which serves as the body’s thermostat. It helps reset the thermostat to a lower temperature, causing the body to cool down and reducing fever.