Phenergan Syrup Uses

Phenergan syrup is a medication that belongs to the class of drugs known as phenothiazines. It has various uses due to its properties as an antihistamine, antiemetic, and sedative. The following are some common uses of Phenergan Syrup:

1. Allergic Conditions: Phenergan syrup is commonly used to relieve symptoms associated with allergic conditions, such as hay fever (allergic rhinitis), allergic conjunctivitis, and allergic skin reactions. It helps reduce itching, sneezing, runny nose, and hives by blocking the effects of histamine, a chemical released during an allergic reaction.
2. Nausea and Vomiting: Phenergan syrup is often used as an antiemetic to manage nausea and vomiting. It can be used for various causes, including motion sickness, postoperative nausea and vomiting, and chemotherapy-induced nausea and vomiting.
3. Sedation and Sleep Aid: Phenergan syrup has sedative properties, and therefore, it may be used as a short-term sleep aid or to induce sedation. It can help promote relaxation and facilitate sleep in certain individuals.
4. Motion Sickness: Phenergan syrup is effective in preventing and alleviating symptoms of motion sickness, such as nausea, vomiting, and dizziness. It can be useful when traveling by car, plane, or boat.
5. Cough and Cold Symptoms: Phenergan syrup is sometimes used to relieve coughs and cold symptoms, such as persistent cough, congestion, and runny nose. It helps by reducing irritation in the respiratory tract and suppressing the cough reflex.
6. Treatment of hiccups: Phenergan syrup is also can be used to help treat hiccups.

Off-label Uses of Phenergan Syrup

1. Treatment of Insomnia: Phenergan syrup’s sedative effects may make it useful off-label for the treatment of insomnia. It can be prescribed in cases where other sleep aids have not been effective or are contraindicated.
2. Adjunctive Treatment for Migraines: Phenergan syrup may be used off-label as an adjunctive treatment for migraines in combination with other medications. It can help alleviate nausea and vomiting associated with migraines and enhance the effectiveness of other migraine treatments.
3. Pruritus (itching): Phenergan syrup’s antihistamine properties can be utilized off-label to manage pruritus or itching associated with various skin conditions, such as eczema or urticaria (hives). It can help reduce itching and provide symptomatic relief.
4. Anxiolytic (anti-anxiety) Effects: Phenergan syrup’s sedative properties may be utilized off-label to manage anxiety symptoms in certain individuals. It can help reduce feelings of anxiety and promote a calmer state.

Phenergan Syrup is one of the leading brands of Promethazine in oral Liquid form, manufactured and marketed by Sanofi Aventis (Pakistan) Ltd.

The following are some available alternative brands of Phenergan Syrup and their manufacturers.

• Phenerzine : Epoch Pharmaceutical, Pakistan.
• Pirogan : Alliance Pharmaceuticals (Pvt) Ltd, Pakistan.
• Prometh : Nova Med Pharmaceuticals, Pakistan.
• Regomin : Regent Laboratories Ltd, Pakistan.
• Rintal : Stanley Pharmaceuticals (Pvt) Ltd, Pakistan.
• Carbex Plus : Platinum Pharmaceuticals (Pvt) Ltd, Pakistan
• Costa-Pro : Macter International (Pvt) Ltd, Pakistan.
• Flocozine : Scotmann Pharmaceuticals, Pakistan.
• Chixicol : Libra Pharmaceuticals (Pvt) Ltd, Pakistan.

Presently, Phenergan is available in Syrup, Tablet, and Injection forms with the following strengths.

Phenergan Syrup : 25mg/5ml strength.

Phenergan Tablet : 25mg strength.

Phenergan Injection : 25mg/ml strength.

Phenergan syrup has several contraindications, which means there are specific circumstances or conditions in which its use is not recommended.

• Hypersensitivity: Individuals who have a known hypersensitivity or allergy to Phenergan or any of its components should not take Phenergan syrup. Allergic reactions to Phenergan can range from mild skin rash and itching to severe reactions, including anaphylaxis, which is a potentially life-threatening allergic response.
• Children under 2 years old: Phenergan syrup is generally not recommended for use in children under 2 years old due to the potential risk of respiratory depression and other serious adverse effects. In this age group, alternative medications or treatment options should be considered.
• Respiratory depression: Phenergan syrup is contraindicated in individuals with severe respiratory conditions, such as asthma, chronic obstructive pulmonary disease (COPD), or severe respiratory depression. Phenergan can suppress the respiratory drive, which can be dangerous in individuals with compromised respiratory function.
• Coma or CNS depression: Phenergan syrup should not be used in individuals who are in a coma or have significantly reduced levels of consciousness. It can further depress the central nervous system (CNS) and impair vital functions.
• Liver disease: Phenergan syrup should be used with caution in individuals with liver disease. Liver impairment can affect the metabolism and clearance of Phenergan, potentially leading to increased drug levels and an increased risk of side effects. Dosage adjustments may be necessary in such cases.
• Certain medications: Phenergan syrup may interact with certain medications, such as monoamine oxidase inhibitors (MAOIs), opioids, and sedatives. Concurrent use of these medications with Phenergan syrup can lead to increased sedation, respiratory depression, or other adverse effects. It’s important to inform your healthcare professional about all the medications you are taking to ensure there are no contraindications or potential drug interactions.

Phenergan Syrup Dose for Allergic Reactions:

• Adults: One Teaspoon (25 mg) every 4 to 6 hours as needed.
• Children: A half Teaspoon (12.5 mg) every 4 to 6 hours as needed.

Phenergan Syrup Dose for Nausea and vomiting:

• Adults: One Teaspoon (25 mg) every 4 to 6 hours as needed.
• Children: A half Teaspoon (12.5 mg) every 4 to 6 hours as needed.

Phenergan Syrup Dose for Motion Sickness:

• Adults: One Teaspoon (25 mg) one-half to one hour before travel and then every 6 to 8 hours as needed.
• Children: A Half Teaspoon (12.5) one-half to one hour before travel and then every 6 to 8 hours as needed.

Phenergan Syrup Dose for Sedation:

• Adults: One Teaspoon (25 mg) at bedtime.
• Children: A half Teaspoon (12.5 mg) at bedtime.

Phenergan Syrup Dose for Sleep Aid:

• Adults: One Teaspoon (25 mg) at bedtime.
• Children: A half Teaspoon (12.5 mg) at bedtime.

1. Histamine Antagonist: Phenergan acts as an antagonist (blocker) of histamine H1 receptors. Histamine is a chemical released by the body during allergic reactions, leading to symptoms like itching, sneezing, runny nose, and watery eyes. By blocking the H1 receptors, Phenergan helps reduce these symptoms and provides relief from allergic reactions.
2. Sedation: Phenergan has sedative properties, meaning it can induce a calming and sleep-inducing effect. It exerts its sedative action by blocking certain receptors in the brain, such as dopamine receptors and alpha-adrenergic receptors. This sedative effect can help with sleep disturbances and anxiety.
3. Antiemetic: Phenergan has antiemetic properties, which means it can help alleviate nausea and vomiting. It acts by blocking dopamine receptors in the chemoreceptor trigger zone (CTZ) in the brain, reducing the signals that trigger nausea and vomiting.