Peridone Tablet Uses

Peridone is a medication that is primarily used for nausea and vomiting. It helps to enhance the movement of food through the digestive system and can be used for the treatment of other gastrointestinal disorders and related symptoms.

The following are some common uses and indications of Peridone:

1. Gastroparesis: Peridone tablet is used to treat gastroparesis, a condition in which the stomach takes longer than normal to empty its contents. This can lead to symptoms like nausea, vomiting, bloating, and early satiety.
2. Nausea and Vomiting: Peridone is used to alleviate nausea and vomiting, which can be caused by various factors such as chemotherapy, surgery, migraine, and certain medications.
3. Reflux Esophagitis: Peridone tablet may be prescribed to manage symptoms of reflux esophagitis, a condition where stomach acid backs up into the esophagus, causing heartburn and other discomfort.
4. Functional Dyspepsia: Peridone may be used in cases of functional dyspepsia, a condition characterized by chronic or recurrent pain or discomfort centered in the upper abdomen.
5. Migraine-associated Nausea and Vomiting: Peridone may be prescribed to help manage nausea and vomiting associated with migraines.
6. Postoperative Nausea and Vomiting: Peridone tablets may be used to prevent or treat nausea and vomiting following surgical procedures.

Off-label Uses of Peridone Tablet

1. Increasing Breast Milk Production: Peridone tablet has been used off-label to stimulate and increase breast milk production in lactating mothers. It works by blocking the action of dopamine, which can lead to an increase in prolactin levels, a hormone responsible for milk production.
2. Gastroesophageal Reflux Disease (GERD): In some cases, Peridone tablets may be used off-label to help manage symptoms of GERD, particularly in individuals who do not respond well to other treatments.
3. Nausea and Vomiting in Pregnancy (Morning Sickness): Peridone tablet has been considered off-label for managing nausea and vomiting in pregnant individuals, although its use during pregnancy is controversial and should be carefully monitored by a healthcare provider.
4. Cyclic Vomiting Syndrome (CVS): Some studies have explored the use of Peridone tablets in individuals with cyclic vomiting syndrome, a disorder characterized by recurrent episodes of severe vomiting.
5. Parkinson’s Disease: In some cases, Peridone tablets may be considered off-label to manage gastrointestinal symptoms in individuals with Parkinson’s disease, as it can help with issues like delayed gastric emptying.
6. Cancer-Related Nausea and Vomiting: Peridone tablet has been explored for its potential to manage nausea and vomiting associated with cancer treatments, although other anti-emetic medications are typically preferred.

Peridone is one of the leading brands of Domperidone, manufactured and marketed by Sami Pharmaceuticals (Pvt) Ltd, Pakistan.

The following are some alternative brands of Peridone and their manufacturers.

• Domel : Barrett Hodgson Pakistan (Pvt) Ltd
• Motilium : Janssen Pharmaceutica.
• Vomilux : Atco Laboratories, Pakistan.
• Pelton V : Global Pharmaceuticals (Pvt) Ltd, Pakistan.
• Emiset : Platinum Pharmaceuticals (Pvt) Ltd, Pakistan.
• Domflash : Next Pharma (Pvt) Ltd, Pakistan.
• Stomacol : High Q Pharmaceuticals (Pvt) Ltd, Pakistan.
• Nomit : Le Mendoza Pharmaceuticals (Pvt) Ltd, Pakistan.
• Emidone : Pharmix Laboratories (Pvt) Ltd.
• Millium : English Pharmaceuticals Industries.

Presently, Peridone is available in Tablet and Syrup forms.

Peridone Tablet : 10mg strength.

Peridone Syrup : 1mg/ml strength.

Peridone tablets have certain contraindications, which means there are situations or conditions where the use of the medication is not recommended or should be avoided.

1. Hypersensitivity or Allergy: Individuals who have a known hypersensitivity or allergy to Domperidone or any of the components in the Peridone tablet should avoid its use.
2. Gastrointestinal Hemorrhage or Perforation: Peridone tablets should not be used in cases of gastrointestinal bleeding, obstruction, or perforation.
3. Prolactin-Producing Tumors: Peridone tablets may stimulate prolactin secretion, so it is contraindicated in individuals with known or suspected prolactin-secreting tumors (e.g., prolactinoma).
4. Certain Heart Conditions: Peridone tablet may lead to QT interval prolongation, which can be serious for individuals with certain heart conditions, including:
   Arrhythmias (irregular heart rhythms)
   Conduction disorders
   Severe cardiac insufficiency
5. Liver Dysfunction: Peridone tablet is metabolized in the liver, and its use is contraindicated in individuals with severe hepatic impairment.
6. Concomitant Use with Medications that Prolong QT Interval: Peridone tablets should not be used with other medications that are known to prolong the QT interval, as this can increase the risk of serious cardiac side effects.
7. Concomitant Use with Strong CYP3A4 Inhibitors: Peridone tablets should not be used with medications that are strong inhibitors of the CYP3A4 enzyme, as this can lead to increased blood levels of Peridone tablets.
8. Breast Cancer and History of Breast Cancer: Peridone tablets should be used with caution in individuals with a history of breast cancer, as it may increase prolactin levels.
9. Children under 12 years of age and Individuals with Low Body Weight: In some regions, Peridone tablet is contraindicated in children under 12 years of age and individuals with a low body weight due to the potential for increased risk of cardiac side effects.

Peridone Tablet Dose for Nausea and Vomiting:

• Adults and adolescents (12 years and older): One tablet of 10 mg, three times a day, before meals and at bedtime.
• The maximum daily dose is usually 30 mg.

Peridone Tablet Dose for Gastroparesis:

• Adults and adolescents (12 years and older): One tablet of 10 mg, three times a day, before meals and at bedtime.
• The maximum daily dose is usually 30 mg.

Peridone Tablet Dose for Reflux Esophagitis:

• Adults and adolescents (12 years and older): One tablet of 10 mg, three times a day, before meals and at bedtime.

Peridone Tablet Dose for Functional Dyspepsia:

• Adults and adolescents (12 years and older): One tablet of 10 mg, three times a day, before meals and at bedtime.

Peridone Dose for Children:

• For children under 12 years of age, the dose is usually lower and is determined by the child’s weight and the specific condition being treated. It’s crucial to consult a pediatrician for appropriate dosing in children.
• Use Peridone Syrup for this age group.

Peridone acts as a dopamine receptor antagonist, meaning it blocks the action of dopamine, a neurotransmitter, in certain areas of the brain and in the upper digestive tract. In the stomach and intestines, dopamine acts to slow down muscle contractions. Peridone blocks this effect, which speeds up the movement of food through the digestive system. This can help to relieve symptoms of nausea, vomiting, and indigestion.