Pelton V Tablet Uses

Pelton V tablet is a medication that is primarily used to treat gastrointestinal disorders. It helps improve the peristalsis movement of the gastrointestinal tract. Following are some common and off-label uses of Pelton V tablets:

Common Uses of Pelton V Tablet

1. Gastroesophageal Reflux Disease (GERD): Pelton V Tablets can be used to relieve symptoms of GERD, including heartburn, regurgitation, and difficulty swallowing, by promoting the movement of food through the digestive system and reducing reflux.
2. Improvement of Gastric Motility: Pelton V tablets help stimulate the muscles of the gastrointestinal tract, particularly in the stomach and intestines. This can be beneficial in conditions characterized by delayed gastric emptying, such as diabetic gastroparesis, where food moves slowly through the digestive system.
3. Nausea and Vomiting: Pelton V tablets can be used to manage acute or chronic nausea and vomiting caused by various factors, including functional dyspepsia, diabetic gastroparesis, chemotherapy, or postoperative recovery.
4. Functional Dyspepsia: Pelton V tablets may be used for the treatment of functional dyspepsia, a condition characterized by recurring pain or discomfort in the upper abdomen, bloating, and early satiety.

Off-label Uses of Pelton V Tablet

1. Increasing Breast Milk in Lactating Women: Pelton V tablet has been used off-label to enhance milk production in breastfeeding women who may be experiencing low milk supply.
2. Irritable Bowel Syndrome (IBS): In some cases, Pelton V tablets may be used to alleviate symptoms of IBS, including abdominal pain, bloating, and altered bowel movements.

Pelton V is one of the leading brands of Domperidone, manufactured and marketed by Global Pharmaceuticals (Pvt) Ltd, Pakistan.

The following are some available alternative brands of Pelton V and their manufacturers.

• Motilium : Janssen Pharmaceutica.
• Peridone : Sami Pharmaceuticals (Pvt) Ltd, Pakistan.
• Vomilux : Atco Laboratories, Pakistan.
• Domel : Barrett Hodgson Pakistan (Pvt) Ltd.
• Emiset : Platinum Pharmaceuticals (Pvt) Ltd, Pakistan.
• Domflash : Next Pharma (Pvt) Ltd, Pakistan.
• Stomacol : High Q Pharmaceuticals (Pvt) Ltd, Pakistan.
• Nomit : Le Mendoza Pharmaceuticals (Pvt) Ltd, Pakistan.
• Emidone : Pharmix Laboratories (Pvt) Ltd.
• Millium : English Pharmaceuticals Industries.

Presently, Pelton V is available in Tablets and Suspension Forms with the following strengths.

Pelton V Tablet : Domperidone 12.72mg strength.

Pelton V Suspension : Domperidone 1mg/ml strength.

Pelton C Tablet : Domperidone 19.1mg + Cinnarizine 20mg strength.

Pelton V has some contraindications, and its use should be avoided or carefully considered in the following situations:

• Hypersensitivity: Individuals with known hypersensitivity or allergic reactions to Pelton V or any of its components should not use this medication.
• Prolactin-releasing pituitary tumor (prolactinoma): Pelton V can increase the release of prolactin, a hormone involved in lactation. Therefore, it should not be used in individuals with a pituitary tumor that releases prolactin.
• Gastrointestinal bleeding, obstruction, or perforation: Pelton V should not be used if there is a risk of gastrointestinal bleeding, obstruction, or perforation, as it may increase the risk of complications.
• Moderate to severe liver impairment: Pelton V is primarily metabolized in the liver, so caution should be exercised when using this medication in individuals with moderate to severe liver impairment. Dosage adjustments or alternative treatment options may be necessary.
• QT prolongation and cardiac arrhythmias: Pelton V can potentially prolong the QT interval, which may increase the risk of cardiac arrhythmias. Therefore, it should be used with caution or avoided in individuals with a history of heart rhythm disorders or those taking medications known to prolong the QT interval.
• Concomitant use with medications that interact with Pelton V: Pelton V can interact with certain medications, including those that inhibit the CYP3A4 enzyme (such as ketoconazole and erythromycin) or medications that prolong the QT interval. Careful consideration and monitoring are required when using Pelton V with these medications.

Pelton V Dose for Adults with Nausea and Vomiting: 1 – 2 tablets taken three to four times a day before meals and at bedtime.
The maximum daily dose should not exceed 6 tablets.

Pelton V Dose for Adults with gastroesophageal reflux disease (GERD): 1 – 2 tablets taken three to four times a day before meals and at bedtime.
The maximum daily dose should not exceed 6 tablets.

Pelton V Dose for Adults with Gastroparesis: 1 – 2 tablets taken three to four times a day before meals and at bedtime.
The maximum daily dose should not exceed 6 tablets.

Pelton V’s mode of action involves its interaction with dopamine receptors in the gastrointestinal tract. It acts as a dopamine antagonist, specifically targeting the dopamine D2 receptors.

By blocking these receptors in the gut, Pelton V inhibits the inhibitory effects of dopamine on gastrointestinal motility. This blockade results in an increase in the release of acetylcholine, a neurotransmitter that promotes smooth muscle contractions in the digestive system.

The enhanced release of acetylcholine leads to increased peristaltic movements, improved gastric emptying, and enhanced coordination of the muscular contractions in the gastrointestinal tract.

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