Orno Tablet Uses

Orno tablet is a non-steroidal anti-inflammatory drug (NSAID) that is used to relieve pain and reduce inflammation. It is known as a quick-action medication that provides relief from mild to moderate pain.

The following are some common uses and indications of Orno Tablet:

1. Pain Relief: Orno tablet is often prescribed to alleviate pain caused by various conditions, including:
   (1.) Musculoskeletal pain: Such as back pain, joint pain, and muscle strains.
   (2.) Postoperative pain: After surgical procedures to help manage pain during the recovery period.
   (3.) Dental pain: For relief from dental procedures or toothaches.
2. Inflammatory Conditions: Orno tablet is used to reduce inflammation associated with conditions like:
   (1.) Rheumatoid arthritis: A chronic autoimmune disease that affects the joints.
   (2.) Osteoarthritis: A degenerative joint disease.
   (3.) Ankylosing spondylitis: A type of arthritis that primarily affects the spine.
3. Fever: Using Orno tablet can also help reduce fever in individuals with elevated body temperature due to an underlying condition.

Off-label Uses of Orno Tablet

1. Migraine Headaches: Orno tablet may be used off-label to provide relief from acute migraine headaches. Some studies have suggested that it may be effective in reducing the severity and duration of migraines.
2. Fibromyalgia: Some studies have explored the use of Orno tablets in individuals with fibromyalgia, a chronic pain condition characterized by widespread musculoskeletal pain and tenderness. It may be used to help manage pain and inflammation associated with this condition.
3. Rheumatic Conditions in Children: Orno tablet may be used off-label to manage pain and inflammation associated with rheumatic conditions in pediatric patients. This may include conditions like juvenile idiopathic arthritis.
4. Gynecological Pain: Orno tablet may be used off-label to alleviate pain associated with gynecological conditions, such as dysmenorrhea (painful menstruation) or pelvic pain.
5. Postpartum Pain: Orno tablet may be used off-label to provide pain relief for women after childbirth, particularly in cases where other pain management options are not suitable.

Orno is one of the leading brands of Lornoxicam, manufactured and marketed by Sami Pharmaceuticals (Pvt) Ltd, Pakistan.

The following are some alternative brands of POrno and their manufacturers.

• Xika-Rapid : Hilton Pharmaceuticals (Pvt) Ltd. Pakistan
• Acabel : Continental Pharmaceuticals (Pvt) Ltd, Pakistan
• Zafon Fast : Getz Pharmaceuticals (Pvt) Ltd. Pakistan
• Actcam : Atco Laboratories (Pvt) Ltd. Pakistan
• Spedicam : Pharmevo Pakistan (Pvt) Ltd
• Mobirom : Saffron Pharmaceuticals (Pvt) Ltd. Pakistan
• Lonex : Mcolson Research Laboratories. Pakistan
• Xoni-Fast : Macter International (Pvt) Ltd. Pakistan
• Olaway : Horizon Pharmaceuticals Pvt Ltd. Pakistan
• Lorzaf : Dyson Research Laboratories. Pakistan

Presently, Orno is available in Tablet and Injection forms.

• Orno Tablet : 8mg strength.
• Orno Injection : 8mg/Vial + 2ml Sterile Water

Orno tablets have certain contraindications, which means there are situations or conditions where the use of the medication is not recommended or should be avoided.

1. Hypersensitivity or Allergy: Individuals who have a known hypersensitivity or allergy to Lornoxicam or any of the components in the Orno tablet should avoid its use.
2. Asthma, Urticaria, or Allergic-Type Reactions to Aspirin or Other NSAIDs: Individuals who have a history of asthma, urticaria (hives), or allergic-type reactions (including skin reactions) to aspirin, other NSAIDs (e.g., ibuprofen, naproxen), or Orno tablet should avoid its use.
3. Active Peptic Ulcer or History of Gastrointestinal Bleeding or Perforation: Orno tablet may increase the risk of gastrointestinal bleeding or perforation. It should be avoided in individuals with active peptic ulcers or a history of gastrointestinal bleeding or perforation.
4. Severe Heart Failure: Orno tablet may lead to fluid retention and worsen heart failure symptoms. It should be avoided in individuals with severe heart failure.
5. Severe Renal Impairment or Failure: Orno tablet is contraindicated in individuals with severe renal impairment (creatinine clearance less than 30 mL/min) or end-stage renal disease.
6. Severe Hepatic Impairment or Active Liver Disease: Orno tablet should be avoided in individuals with severe hepatic impairment or active liver disease, as it may exacerbate these conditions.
7. Third Trimester of Pregnancy: Orno tablet should not be used in the third trimester of pregnancy, as it may cause harm to the fetus and lead to complications in labor.
8. Breastfeeding: Orno tablet is excreted in breast milk and may affect the nursing infant. It should be avoided in breastfeeding mothers.
9. Children and Adolescents: Orno tablet is generally not recommended for use in children and adolescents under 18 years of age.
10. Concomitant Use of Anticoagulants: Orno tablet may increase the risk of bleeding, particularly when used with anticoagulant medications like warfarin.

Orno Tablet Dose for Mild to Moderate Pain:

• One tablet of 8mg, twice a day.
• The maximum recommended daily dosage is 16 mg.

Orno Tablet Dose for Rheumatoid Arthritis and Osteoarthritis:

• Initial Dose: One tablet of 8mg 3 – 4 times a day.
• The maintenance dosage should not exceed 16mg daily.

Orno Tablet Dose for Ankylosing Spondylitis and Acute Gout:

• One tablet of 8mg, 2 two times a day.

Orno Tablet Dose for Postoperative Pain:

• One tablet of 8mg, once or twice daily.
• The maximum recommended daily dosage is 24 mg.

Lornoxicam tablets should be taken with food or milk to reduce the risk of stomach upset.

Orno works by inhibiting the activity of cyclooxygenase (COX) enzymes. By inhibiting COX enzymes, the Orno tablet decreases the synthesis of prostaglandins. Prostaglandins are lipid compounds that play a key role in mediating pain, inflammation, and fever.

There are two main isoforms of COX: COX-1 and COX-2.

COX-1 Inhibition: COX-1 is constitutively expressed in many tissues and is involved in maintaining normal physiological functions, including the protection of the gastric mucosa and the regulation of platelet aggregation. Inhibition of COX-1 can lead to reduced platelet aggregation and potential gastrointestinal side effects.

COX-2 Inhibition: COX-2 is induced in response to inflammation and is primarily responsible for the production of prostaglandins associated with pain, inflammation, and fever. Inhibiting COX-2 helps reduce the production of these inflammatory mediators.