Onato Tablet Uses

Onato Tablet is a medication that belongs to a class of drugs known as calcium channel blockers. It is commonly used to treat several cardiovascular conditions, primarily related to high blood pressure (hypertension) and certain heart conditions. The following are some common uses and indications of Onato Tablet:

1. Hypertension (High Blood Pressure): Onato tablet is commonly used to lower blood pressure in individuals with hypertension. It helps relax and widen the blood vessels, making it easier for the heart to pump blood and reducing overall blood pressure.
2. Angina Pectoris (Chest Pain): Onato tablets can also be used to treat chronic stable angina, which is a type of chest pain that occurs when the heart doesn’t receive enough blood flow. By dilating blood vessels, Onato tablet can increase blood supply to the heart muscle, reducing the frequency and severity of angina attacks.
3. Vasospastic Angina (Prinzmetal’s Angina): This is another form of angina caused by spasms in the coronary arteries. The use of Onato tablet can help prevent these spasms, reducing the frequency of angina episodes.
4. Coronary Artery Disease: Onato tablets may be used as part of the treatment for coronary artery disease, a condition where the arteries that supply blood to the heart become narrowed.
5. Raynaud’s Phenomenon: Onato tablet is sometimes used to treat Raynaud’s phenomenon, a condition where the blood vessels in the fingers and toes constrict excessively in response to cold or stress.
6. Heart Failure: In some cases, Onato tablet may be used as an adjunctive treatment for heart failure. It can help reduce the workload on the heart by dilating blood vessels.

Off-label Uses of Onato Tablet

1. Migraine Prevention: Onato tablet’s ability to dilate blood vessels may be beneficial for some individuals who experience migraines, especially those with a vascular component.
2. Prevention of Cluster Headaches: Onato tablet’s vasodilatory effects may help prevent cluster headaches, a type of severe headache that tends to occur in cyclical patterns.
3. Pulmonary Hypertension: Onato tablet’s ability to relax blood vessels may be beneficial in certain cases of pulmonary hypertension, a condition characterized by high blood pressure in the arteries of the lungs.
4. Peripheral Arterial Disease: Onato tablets may be considered off-label in some cases of peripheral arterial disease, a condition where narrowed arteries reduce blood flow to the limbs, particularly the legs.
5. Vasospastic Disorders: Onato tablets may be used off-label for conditions characterized by blood vessel spasms, such as certain types of Raynaud’s phenomenon or other vasospastic disorders.
6. Prevention of Hypertensive Crises: Onato tablets may be used to help prevent hypertensive crises in individuals with a history of severely elevated blood pressure.
7. Post-Stroke Management: In some cases, Onato tablet may be used as part of a comprehensive treatment plan for individuals who have had a stroke, particularly if high blood pressure is a contributing factor.
8. Diabetic Nephropathy: Onato tablets may be considered as part of a treatment plan for individuals with diabetes who have kidney complications, as it can help lower blood pressure and reduce strain on the kidneys.

Onato is one of the leading brands of Amlodipine, manufactured and marketed by Sami Pharmaceuticals (Pvt) Ltd, Pakistan.

The following are some alternative brands of Amodip and their manufacturers.

• Norvasc : Pfizer Laboratories Inc.
• Sofvasc : Wilsons Pharmaceuticals, Pakistan.
• Amodip : Mass Pharma (Pvt) Ltd, Pakistan
• Ampress : Barrett Hodgson Pakistan (Pvt) Ltd.
• Hypotin : Donvalley Pharmaceuticals (Pvt) Ltd. Pakistan.
• Lodopin : Martin Dow Marker Ltd, Pakistan.
• Zodip : Zafa Pharmaceutical Laboratories (Pvt) Ltd. Pakistan.
• Coram : Brookes Pharmaceutical Laboratories Pakistan, Ltd.
• Lodopin : Martin Dow (Pvt) Ltd.
• Amdipine : Nabiqasim Industries (Pvt) Ltd. Pakistan.
• Cardiovasc : Werrick Pharmaceuticals.
• Amlod : Atco Laboratories Ltd. Pakistan.

Presently, Onato is available in Tablet form.

• Onato Tablet : 5mg and 10mg strengths.

Onato tablets have certain contraindications, which means there are specific conditions or situations in which the medication should not be used.

• Allergy or Hypersensitivity: Individuals who have a known allergy or hypersensitivity to Amlodipine or any of its components should not use Onato tablet.
• Severe Aortic Stenosis: Onato tablets should be avoided in individuals with severe aortic stenosis, a condition where the aortic valve in the heart is narrowed, as it may worsen the obstruction.
• Hypotension (Low Blood Pressure): Onato tablet can lower blood pressure, so it is generally contraindicated in individuals with severe hypotension.
• Cardiogenic Shock: Onato tablet is contraindicated in individuals with cardiogenic shock, a condition where the heart is unable to pump enough blood to meet the body’s needs.
• Pregnancy and Breastfeeding: Although Onato tablet is generally considered safe during pregnancy and breastfeeding, it should only be used if the potential benefits outweigh the potential risks. It’s important for pregnant or breastfeeding individuals to discuss the risks and benefits with their healthcare provider.
• Liver Dysfunction: Onato tablet is primarily metabolized in the liver, so caution is advised in individuals with severe liver dysfunction. It may be necessary to adjust the dosage or choose an alternative medication.
• Certain Drug Interactions: Onato tablets can interact with certain medications, such as strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) or inducers (e.g., rifampin), potentially leading to harmful effects. It’s important for individuals taking other medications to inform their healthcare provider.
• Children and Infants: Onato tablet is generally not recommended for use in children under the age of 6 years old due to limited data on its safety and effectiveness in this age group.
• Elderly Patients: While Onato tablets can be used in elderly patients, caution should be exercised, especially in those with other medical conditions or taking multiple medications.

Onato Tablet dose for the Treatment of Hypertension (high blood pressure):

• For Adults: 5 mg once daily.
• The dosage may be adjusted based on individual response and can range from 2.5 mg to 10 mg once daily.

Onato Tablet dose for the treatment of angina (chest pain):

• 5 mg once daily.
• Again, the dosage may be adjusted based on individual response.

Onato Tablet dose for Coronary Artery Disease and Angina:

• 5-10 mg once daily.
• Your doctor may prescribe a higher dose if needed.

Onato is a calcium channel blocker, which means it works by blocking the movement of calcium ions into cells. This has a relaxing effect on the cells, which can help to lower blood pressure and relieve chest pain.