Neupred Syrup Uses

Neupred syrup is a medication that belongs to a class of drugs called corticosteroids. It is a synthetic form of the hormone cortisol, which is naturally produced by the adrenal glands in the body. Neupred syrup is primarily used to treat a variety of medical conditions, such as:

1. Inflammatory Conditions: Neupred syrup is often used to reduce inflammation associated with various conditions, including:
   • Allergic Reactions: It can be prescribed to manage severe allergic reactions, including allergic rhinitis, allergic asthma, and skin reactions like hives or dermatitis.
   • Asthma: Neupred syrup can be used as a short-term treatment during asthma exacerbations to reduce airway inflammation and improve breathing.
   • Arthritis: Neupred syrup may be prescribed to manage symptoms of rheumatoid arthritis, juvenile idiopathic arthritis, or other inflammatory joint conditions.
   • Inflammatory Bowel Disease: Neupred syrup can help reduce inflammation in conditions like Crohn’s disease or ulcerative colitis during flare-ups.
   • Skin Conditions: Neupred syrup may be used to manage severe skin conditions, such as eczema, psoriasis, or allergic dermatitis, to alleviate inflammation and itching.
2. Immune System Disorders: Neupred syrup can be beneficial in treating certain immune system disorders, including:
   • Autoimmune Diseases: Neupred syrup is also used for conditions like systemic lupus erythematosus, autoimmune hepatitis, or autoimmune vasculitis to suppress immune responses and reduce inflammation.
   • Organ Transplants: After an organ transplant, Neupred syrup can be used as an immunosuppressive medication to prevent organ rejection by suppressing the immune system.
3. Respiratory Conditions: Neupred syrup may be prescribed for respiratory conditions that involve inflammation and airway constriction, including:
   • Chronic Obstructive Pulmonary Disease (COPD): It may be used in acute exacerbations of COPD to reduce airway inflammation and improve breathing.
   • Bronchitis: Neupred syrup can help manage inflammation in the airways associated with acute or chronic bronchitis.
4. Other Conditions: Neupred syrup may also be used in the treatment of other medical conditions, including:
   • Adrenal Insufficiency: In cases of adrenal gland dysfunction, Neupred syrup may be used as a replacement therapy to supplement cortisol levels.
   • Nephrotic Syndrome: Neupred syrup can be used to manage nephrotic syndrome, a kidney disorder characterized by excessive protein in the urine and swelling.

Off-label Uses of Neupred Syrup

1. Cancer Treatment: In some cases, Neupred syrup may be used off-label as part of cancer treatment protocols. It can help manage symptoms associated with certain cancers, including lymphomas and leukemias. Additionally, Neupred may be used to reduce nausea and vomiting caused by chemotherapy.
2. Bell’s Palsy: Bell’s palsy is a condition that causes sudden, temporary weakness or paralysis of the facial muscles. Neupred syrup may be used off-label in combination with antiviral medications to reduce inflammation and accelerate recovery in some cases of Bell’s palsy.

Neupred syrup is one of the leading brands of Prednisolone in oral liquid form, manufactured and marketed by Neutro Pharma (Pvt) Ltd, Pakistan.

The following are some alternative brands of Neupred Syrup and their manufacturers.

• Persolon : Shaheen Pharmaceuticals, Pakistan.
• Steron : Xenon Pharmaceuticals (Pvt) Ltd, Pakistan.
• Rapicort : Tabros Pharma, Pakistan.

Presently, Neupred is available in Syrup form.

Neupred Syrup : 15mg/5ml strength.

While Neupred syrup can be effective in treating certain medical conditions, there are some contraindications and precautions to consider.

Hypersensitivity: Individuals who have a known hypersensitivity or allergy to Neupred or any of the ingredients in the syrup should not use the medication. Allergic reactions can range from mild skin rashes to more severe symptoms like difficulty breathing and anaphylaxis.

Active Infections: Neupred syrup can suppress the immune system, which can make it harder for the body to fight off infections. Therefore, it should be used with caution or avoided completely in individuals with active bacterial, viral, or fungal infections.

Systemic Fungal Infections: Certain fungal infections, such as systemic candidiasis, can be worsened by the use of Neupred syrup. It is important to rule out or treat any systemic fungal infections before starting treatment with this medication.

Live Vaccinations: Neupred syrup can weaken the immune system response, making live vaccines less effective. It is generally recommended to avoid live vaccinations while taking Neupred or for a period of time after discontinuing the medication. Inactivated or non-live vaccines are generally safe to administer.

Peptic Ulcer Disease: Neupred syrup can increase the risk of gastric ulcers or worsen existing ulcers. It should be used with caution in individuals with a history of peptic ulcer disease or gastrointestinal bleeding.

Pregnancy and Breastfeeding: Neupred syrup should be used with caution during pregnancy, especially during the first trimester. It may be necessary to balance the potential benefits to the mother against the potential risks to the fetus. Neupred can pass into breast milk, so it is important to consult a healthcare professional before using the medication while breastfeeding.

Diabetes: Neupred syrup can affect blood glucose levels and may interfere with the management of diabetes. Individuals with diabetes should closely monitor their blood sugar levels and consult with their healthcare professionals for appropriate adjustments in diabetes medication dosages while taking Neupred.

Neupred Syrup Dose for Adults:

• For Inflammatory Conditions: The initial daily dose is typically 5 to 60 mg, divided into 2 to 4 doses. Your doctor may adjust the dosage based on your response and gradually decrease it to the lowest effective maintenance dose.
• For Asthma Exacerbations: The recommended dose is often higher initially, ranging from 20 to 60 mg per day, divided into 2 to 4 doses. The dosage is gradually reduced as symptoms improve.

Neupred Syrup Dose for Children:

• • For Inflammatory Conditions: The starting dose is generally 0.14 to 2 mg per kg of body weight per day, divided into 3 to 4 doses. The dose may be adjusted based on the child’s response.
  • For Asthma Exacerbations: The initial dose is typically higher, ranging from 0.5 to 2 mg per kg of body weight per day, divided into 3 to 4 doses. The dosage is gradually reduced as symptoms improve.

Neupred is a synthetic corticosteroid, that exerts its mode of action through several mechanisms in the body. The primary mode of action involves binding to specific glucocorticoid receptors, leading to various physiological effects.

Here is an overview of how Neupred works:

Anti-Inflammatory Effects: Neupred has potent anti-inflammatory properties. It inhibits the production of pro-inflammatory substances, such as cytokines, prostaglandins, and leukotrienes, which are involved in the inflammatory response. By suppressing the immune system’s inflammatory response, Neupred helps reduce redness, swelling, and pain associated with inflammatory conditions.

Immunosuppressive Effects: Neupred acts as an immunosuppressant by dampening the immune system’s response. It inhibits the activation and proliferation of immune cells, such as lymphocytes and monocytes, thereby reducing immune-mediated inflammation. This effect is especially useful in managing autoimmune disorders or preventing organ rejection after transplantation.

Stabilization of Cell Membranes: Neupred helps stabilize cell membranes, making them less permeable to inflammatory substances. This action contributes to reducing the release of inflammatory mediators and preventing the infiltration of immune cells into tissues, further alleviating inflammation.

Modulation of Gene Expression: Neupred influences gene expression by binding to glucocorticoid receptors inside cells. This complex then binds to specific DNA sequences, leading to the regulation of target genes involved in various physiological processes. These genes can affect immune responses, metabolism, and inflammatory pathways.

Suppression of Hypersensitivity Reactions: Neupred helps suppress hypersensitivity reactions by inhibiting the release of histamine and other mediators involved in allergic responses. It reduces the activation of mast cells and basophils, preventing the cascade of allergic symptoms such as itching, swelling, and bronchoconstriction.

Metabolic Effects: Neupred can influence various metabolic processes in the body. It promotes the breakdown of proteins, leading to muscle wasting and the redistribution of body fat. It also enhances gluconeogenesis (glucose production) in the liver, increases blood sugar levels, and can induce insulin resistance.