Nervon Tablet Uses

Nervon tablets are primarily used to treat conditions related to vitamin B12 deficiency. Vitamin B12 is an essential nutrient that plays a crucial role in various bodily functions.

The following are some common indications of Nervon Tablet:

1. Treatment of Vitamin B12 Deficiency: Nervon tablet is used to treat or prevent vitamin B12 deficiency, which can occur due to various factors such as poor diet, certain medical conditions, or as a result of medications like proton pump inhibitors or metformin.
2. Pernicious Anemia: Nervon tablet is often used for individuals with pernicious anemia, a type of anemia characterized by the inability to absorb vitamin B12 from the digestive tract.
3. Neuropathy: Nervon tablet is used in the treatment of neuropathies, which are conditions involving damage or dysfunction of nerves. It may be especially effective in cases of peripheral neuropathy associated with vitamin B12 deficiency.
4. Diabetic Neuropathy: The use of Nervon tablets may be beneficial in managing symptoms of diabetic neuropathy, a type of nerve damage that can occur in people with diabetes.
5. Alcoholic Neuropathy: Nervon tablet may be used to manage neuropathic symptoms in individuals who have developed nerve damage due to chronic alcohol abuse.
6. Nerve Regeneration and Repair: Nervon tablet is believed to support nerve health and may play a role in nerve regeneration and repair.
7. Homocysteine Regulation: Nervon tablet is involved in the conversion of homocysteine to methionine, thereby helping to regulate homocysteine levels in the body. Elevated levels of homocysteine are associated with an increased risk of cardiovascular disease.
8. Cognitive Function: Some studies have investigated the potential benefits of Nervon tablets in supporting cognitive function, particularly in older adults.
9. Support During Pregnancy and Breastfeeding: Adequate vitamin B12 levels are crucial during pregnancy and breastfeeding for the healthy development of the fetus and newborn. Nervon tablets can be used in such conditions.

Off-label Uses of Nervon Tablet

1. Multiple Sclerosis (MS): Nervon tablet may be used off-label for its neuroprotective effect which could potentially be beneficial in the management of certain neurological conditions like multiple sclerosis. However, more research is needed to establish its effectiveness.
2. Amyotrophic Lateral Sclerosis (ALS): Nervon tablet has been investigated as a potential treatment for amyotrophic lateral sclerosis, a progressive neurodegenerative disease affecting motor neurons. However, the evidence for its efficacy in ALS is still limited and inconclusive.
3. Chronic Fatigue Syndrome (CFS): Nervon tablet is used off-label as a treatment option for chronic fatigue syndrome, a complex and poorly understood condition characterized by extreme fatigue that doesn’t improve with rest. Some studies have shown promising results, but more research is needed.
4. Depression and Anxiety: There is limited evidence suggesting that Nervon tablets may have a positive impact on mood and mental well-being, particularly in individuals with vitamin B12 deficiency. It may be used as an adjunctive treatment alongside standard therapies for depression and anxiety.
5. Nerve Damage from Chemotherapy (Chemotherapy-Induced Peripheral Neuropathy): Nervon tablet has been trialed as a potential treatment to alleviate nerve damage associated with certain chemotherapy drugs. It may help in reducing pain and improving nerve function, but further research is needed.
6. Tinnitus: Some studies have investigated the use of Nervon tablets in the management of tinnitus (ringing in the ears). While results have been mixed, Nervon tablet may be considered as part of a comprehensive treatment plan for some individuals with tinnitus.
7. Age-Related Macular Degeneration (AMD): Nervon tablets may have a protective effect on the retina and could potentially be beneficial in age-related macular degeneration. However, more research is needed to establish its effectiveness in this context.

Nervon is one of the leading brands of Mecobalamin, manufactured and marketed by Getz Pharmaceuticals (Pvt) Ltd, Pakistan.

The following are some alternative brands of Nervon and their manufacturers.

• Methycobal : Hilton Pharmaceuticals (Pvt) Ltd, Pakistan.
• Cobolmin : Mecter International, Pakistan.
• Neuromet : Merck Serono Pharmaceutical.
• Mecobal : NabiQasim Pharmaceuticals, Pakistan.
• Mabil : Sami Pharmaceuticals (Pvt) Ltd, Pakistan.
• Mecogen : Genetics Pharmaceuticals, Pakistan.
• Qbal : Bosch Pharmaceuticals, Pakistan
• Bezel : Saffron Pharmaceuticals, Pakistan.
• Incobal : Indus Pharmaceuticals, Pakistan.
• Elgin : Novartis, Pakistan.
• Mylaxzon : Barrett Hodgson Pharmaceuticals, Pakistan.

Presently, Nervon is available in tablet and Injection forms.

Nervon Tablet : 500mcg strength.

Nervon Injection : 500mcg/ml strength.

Like any medication, Nervon has certain contraindications, which are situations or conditions where the use of the medication is not recommended or should be avoided.

Hypersensitivity: Individuals who have a known hypersensitivity or allergy to Mecobalamin or any of the ingredients in the Nervon should avoid its use.

Leber’s Hereditary Optic Neuropathy (LHON): Nervon tablet should not be used in individuals with Leber’s hereditary optic neuropathy, a rare inherited mitochondrial disorder that can cause vision loss.

Polycythemia Vera: Nervon tablet should be used with caution in individuals with polycythemia vera, a condition characterized by an overproduction of red blood cells, as it may exacerbate this condition.

Folate Deficiency Anemia: Nervon tablet supplementation alone may exacerbate folate deficiency anemia. In cases of vitamin B12 deficiency, it is often given in combination with folic acid.

Certain Inherited Metabolic Disorders: Individuals with certain inherited metabolic disorders, such as homocystinuria, should use Nervon tablet with caution and under the guidance of a healthcare professional.

Cancer: Nervon tablets should be used cautiously in individuals with certain types of cancer, particularly those associated with high vitamin B12 levels.

Kidney Disease: Individuals with severe kidney dysfunction may need adjusted dosages of Nervon tablets. It should be used with caution in these cases.

Pregnancy and Breastfeeding: While Nervon tablet is generally considered safe during pregnancy and breastfeeding, it should be used under the guidance of a healthcare provider and in appropriate doses.

Medication Interactions: Nervon tablets may interact with certain medications. For example, it may interact with medications that affect folate metabolism or medications used in the treatment of cancer. It’s important to inform your healthcare provider about all the medications you are taking.

Nervon Dose for Vitamin B12 Deficiency:

• Adults: 2 – 4 tablets per day.
• This may be given as a single daily dose or divided into two doses.

Nervon Dose for Pernicious Anemia:

• Two tablets daily for the first week or two
• Followed by a maintenance dose.

Nervon Dose for Neuropathy Associated with Vitamin B12 Deficiency:

• 1 – 5 tablets per day, depending on the severity of symptoms and the response to treatment.

Nervon Maintenance Therapy:

• Once vitamin B12 levels have been stabilized, a lower maintenance dose may be recommended.
• This could range from 100 to 1,000 mcg taken once a day.

The active ingredient of Nervon is Methylcobalamin, which is an active form of vitamin B12. It serves as a cofactor for two enzymes: methionine synthase and L-methylmalonyl-CoA mutase.

Methionine synthase is involved in the conversion of homocysteine to methionine. Methionine is an essential amino acid that is used in the synthesis of proteins and other important molecules.

L-methylmalonyl-CoA mutase is involved in the metabolism of fatty acids and branched-chain amino acids. A deficiency of this enzyme can lead to the accumulation of methylmalonic acid in the blood, which can cause a variety of neurological problems.