Metrozine Syrup Uses

Metrozine syrup is an antibiotic medication that is used to treat various types of infections caused by certain bacteria and parasites. The following are some common uses and indications of Metrozine Syrup:

1. Bacterial Infections: Metrozine syrup is effective against a wide range of bacterial infections, including:
   • Bacterial Vaginosis: Metrozine is commonly used for the treatment of bacterial vaginosis, an infection of the vagina caused by an imbalance of bacteria.
   • Dental Infections: Metrozine syrup may be used to treat dental infections, including gum infections (gingivitis), dental abscesses, or periodontitis.
   • Helicobacter Pylori Infection: Metrozine is used as part of combination therapy to eradicate Helicobacter pylori bacteria in the stomach, which can cause peptic ulcers.
2. Protozoal Infections: Metronidazole syrup is effective against certain protozoal infections, such as:
   • Trichomoniasis: Metrozine syrup is also used to treat trichomoniasis, a sexually transmitted infection caused by the parasite Trichomonas vaginalis.
   • Amoebiasis: Metrozine syrup can be used to treat amoebic dysentery and amoebic liver abscesses caused by the parasite Entamoeba histolytica.
   • Giardiasis: Metrozine syrup may be used for giardiasis, an intestinal infection caused by the parasite Giardia lamblia.
3. Anaerobic Infections: Metronidazole syrup is particularly effective against anaerobic infections, which are caused by bacteria that thrive in environments without oxygen. These infections can occur in various parts of the body, including the abdomen, pelvis, skin, and soft tissues. Metronidazole syrup may be prescribed to treat anaerobic infections in these areas.

Off-label Uses of Metrozoine Syrup

1. Diverticulitis: Metrozine syrup may be used off-label in the treatment of diverticulitis, which is an inflammation or infection of small pouches that develop in the lining of the colon. It may be prescribed in combination with other antibiotics to target the bacteria responsible for the infection.
2. Bacterial Gastroenteritis: While Metrozine syrup is not commonly used as a first-line treatment for bacterial gastroenteritis, it may be used off-label in certain cases where the infection is severe or resistant to other antibiotics.
3. Rosacea: Metrozine, in various formulations including topical gel or cream, is approved for the treatment of rosacea. In some cases, Metrozine syrup may be used off-label as an oral treatment for severe or refractory cases of rosacea.
4. Inflammatory Bowel Disease (IBD): In certain situations, Metrozine syrup may be used off-label as an adjunct therapy in the treatment of inflammatory bowel diseases (IBD) such as Crohn’s disease or ulcerative colitis, particularly during acute flare-ups.

Metrozine Syrup is one of the leading brands of Metronidazole in oral liquid form, manufactured and marketed by Searle Pakistan (Pvt) Ltd.

The following are some alternative brands of Metrozine syrup and their manufacturers.

Flagyl : Sanofi Aventis (Pakistan) Ltd.

Klint : Sami Pharmaceuticals (Pvt) Ltd, Pakistan.

Riam : Stanley Pharmaceuticals (Pvt) Ltd, Pakistan.

Metrida : Zafa Pharmaceutical Laboratories (Pvt) Ltd, Pakistan.

Amezole : Ferozsons Laboratories Ltd. Pakistan.

Flezole : Pearl Pharmaceuticals, Pakistan.

Amogyl : Davis Pharmaceutical Laboratories, Pakistan.

Ascozole : Asian Continental (Pvt) Company, Pakistan.

Diagyl : Swiss Pharmaceuticals (Pvt) Ltd, Pakistan.

Menidazole : Werrick Pharmaceuticals, Pakistan.

Presently, Metrozine is available in Syrup, Tablet, and Injectable forms.

Metrozine Syrup : 200mg/5ml strength.

Metrozine Tablet : 200mg, 400mg Strengths

Metrozine Injection : 500mg/100ml

Metrozine syrup, like any medication, has certain contraindications—specific situations or conditions in which the use of Metrozine is not recommended due to potential risks or adverse effects.

Hypersensitivity: Metrozine syrup is contraindicated in individuals who have a known hypersensitivity or allergic reaction to Metrozine or any of its components. Allergic reactions to Metrozine can range from mild to severe and may include symptoms such as rash, itching, swelling, difficulty breathing, or anaphylaxis. If you have experienced an allergic reaction to Metrozine or any similar medications in the past, it is important to inform your healthcare professional.

Pregnancy (First Trimester): Metrozine is generally contraindicated during the first trimester of pregnancy due to potential risks to the developing fetus. There is limited evidence regarding the safety of Metrozine during this period, and alternative treatments may be considered. However, the use of Metrozine may be considered if the potential benefits outweigh the risks in certain situations and after consultation with a healthcare professional.

Breastfeeding: Metrozine is excreted in breast milk, and its use during breastfeeding is generally not recommended. It is advisable to avoid Metrozine while breastfeeding unless the potential benefits outweigh the risks and under the guidance of a healthcare professional.

Blood Disorders: Metrozine syrup is contraindicated in individuals with a history of blood disorders, such as blood dyscrasias or disorders affecting the bone marrow. Metrozine can interfere with blood cell production and exacerbate existing blood disorders.

Central Nervous System Disorders: Metrozine syrup should be used with caution or avoided in individuals with a history of central nervous system disorders, such as epilepsy or seizures. Metrozine can potentially lower the seizure threshold and increase the risk of seizures in susceptible individuals.

Metrozine Syrup Dose for Bacterial Infections:

Children over 8 weeks and up to 12 years of age:

• 7.5 mg to 15 mg per kilogram of body weight per day, divided into three to four equal doses.
• The duration of treatment is usually 7 days.

Adults and Children 12 years Above:

• 500 mg to 750 mg taken orally three times a day.
• The total daily dose may vary depending on the specific infection and its severity.

Metrozine Syrup Dose for Protozoal Infections (amoebiasis, trichomoniasis, and giardiasis):

Adults and Children 12 years Above:

• The recommended dose of metronidazole syrup is usually higher.
• 1.5 grams per day, divided into three equal doses.

Children (Under 12 years of age):

• The dose is based on body weight, with a typical range of 35 to 50 mg per kilogram of body weight per day, divided into three equal doses.

Metrozine is an antibiotic medication that exhibits a unique mode of action against certain types of bacteria and parasites. Its mode of action involves several mechanisms that work together to inhibit the growth and reproduction of these organisms. Here’s an overview of how Metrozine works:

Disruption of DNA Function: Metrozine enters bacterial and protozoal cells and is activated by specific enzymes. Once activated, it forms toxic compounds that interfere with the DNA of the microorganisms. Metrozine causes damage to the DNA strands, leading to the disruption of DNA replication and synthesis. This inhibits the microorganisms’ ability to multiply and eventually leads to their death.

Reactive Oxygen Species (ROS) Formation: Metrozine can generate reactive oxygen species (ROS) within the microbial cells. ROS are highly reactive molecules that can cause damage to proteins, lipids, and DNA. The formation of ROS contributes to the antimicrobial activity of Metrozine by causing oxidative stress and further disrupting essential cellular processes in the microorganisms.

Anaerobic Conditions: Metrozine is particularly effective against anaerobic bacteria and parasites, which thrive in environments devoid of oxygen. The drug is selectively taken up by these anaerobes due to their unique metabolic processes. Within the anaerobic environment, Metrozine is reduced by enzymes specific to these microorganisms, leading to the formation of cytotoxic metabolites that exert antimicrobial effects.

Anti-Inflammatory Effects: Metrozine has been shown to possess anti-inflammatory properties. It can modulate the immune response and reduce the production of certain pro-inflammatory substances, such as cytokines and chemokines. This anti-inflammatory activity contributes to the drug’s effectiveness in treating certain inflammatory conditions, particularly those associated with bacterial or protozoal infections.

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