Metomide Syrup Uses

Metomide syrup is a medication used to treat a variety of gastrointestinal conditions. Using this syrup helps to increase the movement of the stomach and intestines, and can help relieve symptoms such as nausea, vomiting, and discomfort. The following are some common uses and indications of Metomide Syrup:

1. Nausea and Vomiting: Metomide syrup is often used to manage nausea and vomiting associated with various conditions, including chemotherapy-induced nausea, postoperative nausea, migraines, and gastrointestinal disorders like gastroparesis (delayed stomach emptying).
2. Gastroparesis: Gastroparesis is a condition in which the stomach muscles do not function properly, leading to delayed stomach emptying. Metomide can help improve stomach emptying and reduce symptoms such as nausea, vomiting, and bloating.
3. GERD (Gastroesophageal Reflux Disease): Metomide syrup might be used to relieve symptoms of GERD, a condition in which stomach acid flows back into the esophagus, causing heartburn, regurgitation, and discomfort.
4. Radiation-Induced Nausea and Vomiting: Metomide can be used to manage nausea and vomiting caused by radiation therapy.
5. Prevention of Nausea and Vomiting After Surgery: Metomide might be used to prevent postoperative nausea and vomiting in certain surgical procedures.

Off-label Uses of Metomide Syrup

1. Breast Milk Production: Metomide syrup has been used off-label to stimulate breast milk production (lactation) in breastfeeding mothers. It is believed to increase the release of the hormone prolactin, which is responsible for milk production. However, its use for this purpose is controversial, and other options are typically considered first.
2. Hiccups: Metomide syrup has been used off-label to manage persistent or intractable hiccups that do not respond to other treatments. It is thought to work by affecting the reflex arc responsible for hiccups.
3. Diabetic Gastroparesis: While Metomide syrup is indicated for gastroparesis, it may also be used off-label to manage gastroparesis in individuals with diabetes.
4. Reflux Esophagitis: In some cases, Metomide syrup may be used off-label to help manage reflux esophagitis, a condition characterized by inflammation of the esophagus due to stomach acid reflux.
5. Hyperemesis Gravidarum: Metomide syrup may be used off-label to manage severe nausea and vomiting during pregnancy, a condition known as hyperemesis gravidarum. However, the safety of Metomide during pregnancy is a topic of ongoing research and debate.
6. Post-operative Gastrointestinal Function: Metomide syrup might be used off-label to promote gastrointestinal motility and function after certain surgeries.
7. Migraine Treatment: Metomide syrup might be used off-label as an adjunct to other migraine treatments, especially when nausea and vomiting are significant symptoms.

Metomide syrup is one of the leading brands of Metoclopramide, manufactured and marketed by (CCL) Consolidated Chemical Laboratories (Pvt) Ltd, Pakistan.

The following are some alternative brands of Metomide Syrup and their manufacturers.

Metoclon : Indus Pharma (Pvt) Ltd, Pakistan.

Maxolon : GlaxoSmithKline (GSK) Pakistan.

Cloprel : Hamza Pharmaceutical (Pvt) Ltd, Pakistan.

M-Clon : Sharex Laboratories (Pvt) Ltd, Pakistan.

Metoca : Neutro Pharma (Pvt) Ltd, Pakistan.

Metolon : Mediceena Pharma (Pvt) Ltd, Pakistan.

Metopride : Atlantic Pharmaceuticals (Pvt) Ltd, Pakistan.

Metorex : Rex Pharmaceuticals, Pakistan.

Clopra : Neo-Medix, Pakistan.

Emetal : Elbro Pharma, Pakistan.

Presently, Metomide is available in Syrup, Tablet, Injection, and Drop forms.

Metomide Syrup : 5mg/ml strength.

Metomide Tablet : 10mg strength.

Metomide Injection : 5mg/ml strength.

Metomide Drop : 1mg/ml strength.

Here are certain contraindications and precautions that individuals should be aware of before using Metomide.

Contraindications:

• Gastrointestinal Obstruction: Metomide is contraindicated in individuals with known or suspected gastrointestinal obstruction, as it may exacerbate the obstruction or delay diagnosis.
• Gastrointestinal Hemorrhage, Perforation, or Obstruction: Metomide should not be used in cases of active gastrointestinal bleeding, perforation, or mechanical obstruction.
• Pheochromocytoma: Metomide is contraindicated in individuals with pheochromocytoma, a rare tumor that affects the adrenal glands and can cause high blood pressure and other symptoms.
• Hypersensitivity: Individuals who have a known hypersensitivity or allergy to Metomide or any of its components should not use this medication.
• History of Tardive Dyskinesia or Neuroleptic Malignant Syndrome (NMS): Metomide is contraindicated in individuals with a history of tardive dyskinesia (involuntary movements) or neuroleptic malignant syndrome (a serious neurological disorder) related to prior use of Metomide or other dopamine antagonists.

Precautions:

• Parkinson’s Disease: Metomide should be used with caution in individuals with Parkinson’s disease, as it may worsen movement-related symptoms.
• Seizure Disorders: Metomide should be used cautiously in individuals with a history of seizure disorders, as it may lower the seizure threshold.
• Renal Impairment: Dose adjustment may be necessary for individuals with moderate to severe renal impairment.
• Hepatic Impairment: Metomide should be used with caution in individuals with moderate to severe hepatic impairment.
• Elderly Patients: Elderly individuals may be more susceptible to the neurological side effects of Metomide.
• Pregnancy and Breastfeeding: The safety of Metomide during pregnancy and breastfeeding is a topic of ongoing research and discussion. It should be used with caution in pregnant or breastfeeding individuals, and the potential risks and benefits should be carefully evaluated.

Metomide Syrup Dose for Nausea and Vomiting:

• Adults: 10-20 mg (2-4 Teaspoons) taken three to four times a day, before meals and at bedtime.
• Children (6 months to 18 years): The dose depends on the child’s weight and may range from 0.1 to 0.2 mg/kg per dose, given three to four times a day. The maximum daily dose is usually around 0.5 mg/kg.

Metomide Syrup Dose for Gastroparesis:

• Adults: 10 mg (2 Teaspoons) taken four times a day, before meals and at bedtime.
• Children (1 to 18 years): The dose depends on the child’s weight and may range from 0.1 to 0.15 mg/kg per dose, given four times a day.

Metomide Syrup Dose for Gastroesophageal Reflux Disease (GERD):

• Adults: 10-15 mg (2-3 Teaspoons) taken up to four times a day before meals and at bedtime. The total daily dose should not exceed 60 mg.
• Children: The dose for children is typically based on body weight and should be determined by a healthcare provider.

Metomide is a dopamine receptor antagonist that works by blocking the action of dopamine in the brain and gut. This action has two effects:

1. It increases the release of acetylcholine, a neurotransmitter that stimulates the muscles of the stomach and intestines to contract. This results in increased gastric motility, or the movement of food through the stomach and intestines.
2. It blocks the action of dopamine in the chemoreceptor trigger zone (CTZ), a region of the brain that is responsible for nausea and vomiting. This action prevents nausea and vomiting caused by a variety of stimuli, including motion sickness, chemotherapy, and surgery.