Manacid Syrup Uses

Manacid Syrup is an antacid medication, which is primarily used to treat acid-related gastrointestinal issues such as heartburn, acid indigestion, and gas. It can also used for stomach discomfort caused by eating or drinking too much. Following are some approved and off-label uses of Manacid Syrup:

Approved Uses of Manacid Syrup

1. Acid Reflux and Gastroesophageal Reflux Disease (GERD): Manacid syrup can be used to manage symptoms associated with acid reflux and GERD, such as acid regurgitation, sour taste in the mouth, and chest discomfort. By neutralizing stomach acid, it helps alleviate these symptoms.
2. Gastric and Duodenal Ulcers: Manacid syrup is often used in the treatment of gastric and duodenal ulcers. It helps neutralize gastric acid, which can reduce irritation and promote healing of the ulcers.
3. Heartburn and Indigestion: Manacid syrup can be used to relieve the symptoms of heartburn, indigestion, and stomach upset caused by excessive gastric acid production. It helps neutralize stomach acid and alleviate the discomfort associated with these conditions.
4. Constipation: Magnesium hydroxide, one of the active ingredients in Manacid syrup, can act as a mild laxative. It helps promote bowel movements and relieve constipation.
5. Gas and Bloating: The use of Manacid syrup provides an anti-foaming effect that helps reduce gas bubbles in the gastrointestinal tract, which can alleviate symptoms of gas, bloating, and discomfort.

Off-label Uses of Manacid Syrup

1. Functional Dyspepsia: Functional dyspepsia is a condition characterized by recurring or chronic indigestion symptoms without an identifiable cause. In some cases, Manacid syrup may be used off-label to alleviate the symptoms of functional dyspepsia, such as upper abdominal pain, bloating, and early satiety.
2. Gastritis: Gastritis refers to inflammation of the stomach lining. While Manacid syrup is not specifically approved for this condition, Its antacid properties may provide temporary relief from gastritis symptoms, including abdominal pain, nausea, and vomiting.
3. Acid-related Respiratory Disorders: In some cases, excess stomach acid can lead to respiratory symptoms such as chronic cough, hoarseness, or throat irritation. The use of Manacid syrup may be considered to help reduce gastric acid and alleviate these respiratory symptoms.
4. Gastrointestinal Reflux in Infants: Gastroesophageal reflux (GER) is a common condition in infants where stomach contents flow back into the esophagus, causing discomfort. While Manacid syrup is not specifically indicated for infants, it may be used under medical supervision to help manage GER symptoms in certain cases.

Manacid Syrup is a combination of Aluminium Hydroxide, Magnesium Hydroxide, and Simethicone, manufactured and marketed by Stanley Pharmaceuticals (Pvt) Ltd, Pakistan.

The following are some alternative brands of Manacid Syrup and their manufacturer.

• Dijex MP : Abbott Laboratories (Pvt) Ltd, Pakistan.
• Trisil Plus : Efroze Chemical Industries (Pvt) Ltd, Pakistan.
• Rejex MP : Rasco Pharma (Pvt) Ltd, Pakistan.
• Colenticon : Pacific Pharmaceuticals Ltd, Pakistan.
• Dimeco : Macter International (Pvt) Ltd, Pakistan.
• Mylanta-2 Pfizer Laboratories Inc.
• Filmacid-M : Searle Pakistan (Pvt) Ltd.
• Balanta : Global Pharmaceuticals, Pakistan.
• Almagel : Zafa Pharmaceutical Laboratories (Pvt) Ltd, Pakistan.
• Siam : Efroze Chemical Industries (Pvt) Ltd, Pakistan.

Presently, Manacid is available in Syrup form.

Manacid Syrup Each 5ml Contains:

• Aluminium Hydroxide: 215mg
• Magnesium Hydroxide: 80mg
• Simethicone: 25mg

Manacid syrup may have contraindications in certain individuals. A contraindication is a specific circumstance or condition that makes the use of this syrup potentially harmful or inappropriate.

• Allergy or Hypersensitivity: Individuals who have a known allergy or hypersensitivity to aluminum hydroxide, magnesium hydroxide, simethicone, or any other ingredients in Manacid syrup should avoid its use.
• Severe Kidney Dysfunction: Manacid syrup can accumulate in the body and potentially worsen kidney function in individuals with severe kidney disease or kidney failure. Therefore, the syrup should be used with caution or avoided in individuals with significant renal impairment.
• Bowel Obstruction: If a person has a known or suspected bowel obstruction, the use of Manacid syrup is contraindicated. These ingredients may increase the risk of bowel perforation or exacerbate the obstruction.
• Electrolyte Imbalance: The use of Manacid can affect electrolyte levels in the body, especially in individuals with existing electrolyte imbalances. Therefore, caution is advised, and medical supervision is necessary in such cases.

Manacid Syrup Dose for Adults and Adolescents (12 years and older)

For relief of Heartburn, Indigestion, and Stomach upset:

• 5-10 ml (1-2 teaspoons) of syrup as needed, usually after meals and at bedtime.

For Constipation Relief:

• 15-30 ml (1-2 tablespoons) of syrup, preferably at bedtime.

Manacid Syrup Dose for Children (6 to 11 years)

• The dosage for children within this age range should be determined by a healthcare professional based on the child’s weight and condition. It is important to follow their instructions for the appropriate dosage.

Manacid Syrup Dose for Children (under 6 years):

• Manacid syrup in children under 6 years old should be done under the guidance and supervision of a healthcare professional.

Manacid syrup form has a multifaceted mode of action that helps alleviate symptoms associated with gastrointestinal conditions. Here’s a breakdown of the mode of action of each ingredient of syrup:

1. Aluminium Hydroxide and Magnesium Hydroxide:
   • Antacid Action: Aluminium hydroxide and magnesium hydroxide are both antacids. They work by neutralizing excess stomach acid (hydrochloric acid) to raise the pH level in the stomach. This helps reduce the acidity of gastric contents and alleviate symptoms such as heartburn, indigestion, and stomach upset.
   • Protection Against Acid-Related Damage: Aluminium hydroxide and magnesium hydroxide can also provide a protective coating effect on the stomach lining, which may help protect against acid-related damage and promote the healing of gastric and duodenal ulcers.
   • Promoting Bowel Movements: Magnesium hydroxide can act as a mild laxative by drawing water into the intestines and promoting bowel movements. This can help relieve constipation.
2. Simethicone:
   • Anti-Foaming Action: Simethicone is an anti-foaming agent that helps reduce the formation and accumulation of gas bubbles in the gastrointestinal tract. It works by breaking down larger gas bubbles into smaller ones, which can be more easily passed or absorbed by the body. This action helps relieve symptoms of excess gas, bloating, and discomfort.