Izato Syrup Uses

Izato Syrup is an antiparasitic and antiviral medication that is used to treat various infections caused by protozoa and certain viruses. Izato Syrup formulation is mostly recommended for children and adults where a low dose of medicine is needed.

Here are some common Indications of Izato syrup:

• Giardia lamblia: A protozoan parasite that causes giardiasis, an infection of the small intestine.
• Cryptosporidium parvum: A protozoan parasite that causes cryptosporidiosis, an infection of the gastrointestinal tract.
• Cyclospora cayetanensis: A protozoan parasite that causes cyclosporiasis, an infection of the small intestine.
• Isospora belli: A protozoan parasite that causes isosporiasis, an infection of the small intestine.
• Ascariasis: A roundworm infection caused by Ascaris lumbricoides.
• Trichuriasis: A whipworm infection caused by Trichuris trichiura.
• Hookworm infection: An infection caused by Ancylostoma duodenale or Necator americanus.

Off-label Uses of Izato Syrup

Other Protozoal Infections: Izato syrup has effectiveness against other protozoal infections, such as amebiasis (caused by Entamoeba histolytica) and cyclosporiasis (caused by Cyclospora cayetanensis), although these uses may be considered off-label.

Izato Syrup is one of the leading brands of Nitazoxanide, manufactured and marketed by Sami Pharmaceuticals (Pvt) Ltd, Pakistan.

The following are some alternative brands of Izato and their manufacturers.

Diatazox : Continental Pharmaceuticals, Pakistan.

NT-Tox : Genix Pharmaceuticals (Pvt) Ltd, Pakistan.

Nitazide : Helix Pharma (Pvt) Ltd, Pakistan.

Atizox : Macter International (Pvt) Ltd, Pakistan.

Nitazert : Hilton Pharmaceuticals (Pvt) Ltd, Pakistan.

Nitazole : Neo Medix, Pakistan.

Presently, Izato is available in Syrup and Tablet forms.

Izato Syrup : 100mg/5ml strength.

Izato Tablet : 500mg strength.

While Izato is generally well-tolerated, there are specific contraindications—situations or conditions where the use of Izato is not recommended.

Hypersensitivity: Individuals who have a known hypersensitivity or allergy to Izato syrup or any of the ingredients in the syrup should not use this medication.

Severe Renal Impairment: Izato syrup is primarily eliminated from the body through the kidneys. Individuals with severe renal impairment or end-stage renal disease may have difficulty clearing the medication from their system, leading to potential accumulation and increased risk of adverse effects.

Hepatic Impairment: Izato syrup is metabolized in the liver. Individuals with severe hepatic impairment may have difficulty metabolizing the medication, which could lead to increased levels in the bloodstream and potential side effects.

Pediatric Patients Under 1 Year: The safety and effectiveness of Izato syrup have not been established in infants younger than 1 year of age.

Concomitant Use with Certain Medications: Izato syrup may interact with certain medications, such as antacids containing magnesium or aluminum, which could affect the absorption of Izato syrup. It’s important to inform your healthcare provider about all the medications you are taking, including over-the-counter products and supplements.

Known G6PD Deficiency: Izato syrup may cause hemolysis (breakdown of red blood cells) in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. If you have this genetic condition, the use of Izato syrup should be carefully considered under medical supervision.

Izato Syrup Dose for Cryptosporidiosis:

• Adults and Children (≥ 12 years): 500 mg (25 ml) taken twice daily with food for 3 days.

Izato Syrup Dose for Giardiasis:

• Adults and Children (≥ 12 years): 500 mg (25ml) taken once daily with food for 3 days.

Izato Syrup Dose for Rotavirus Diarrhea:

• Children (1 to 11 years): The dose is based on body weight and typically ranges from 100 mg to 200 mg (5 to 10 ml) every 12 hours for 3 days.

Izato work by inhibiting the activity of an enzyme called pyruvate ferredoxin oxidoreductase (PFOR). PFOR is an essential enzyme for energy production in parasites and its inhibition by Izato leads to the death of the parasite.