Hydryllin DM Syrup Uses

Hyderlin DM syrup is used to relieve dry and irritating coughs and congestion of the respiratory tract. It can also used to treat allergy symptoms such as runny nose, sneezing, the common cold, or the flu. The following are some common and off-label uses of Hydryllin DM Syrup:

Common Uses of Hyderlin Dm Syrup

1. Cough and Cold: Hydryllin DM syrup is used to relieve cough and cold symptoms. It helps to suppress coughing, reduces congestion, and promotes the loosening and removal of mucus from the respiratory tract.
2. Productive Cough: Hydryllin DM is particularly helpful in treating productive cough, which is a cough associated with excessive mucus production. Hydryllin DM syrup can help thin the mucus and facilitate its expectoration.
3. Bronchitis: Hydryllin DM syrup may be used for the symptomatic relief of bronchitis, an inflammation of the bronchial tubes in the lungs. It can help soothe coughing, reduce congestion, and promote the clearance of mucus from the airways.
4. Upper Respiratory Tract Infections: Hydryllin DM syrup can be used to alleviate symptoms of upper respiratory tract infections, such as sore throat, cough, and nasal congestion.

Off-label Uses of Hydryllin Dm Syrup

1. Sinusitis: Hydryllin DM syrup may be used off-label as part of the treatment plan for sinusitis, which is an inflammation of the sinuses. It can help alleviate symptoms such as nasal congestion, sinus pressure, and productive cough associated with sinus drainage.
2. Allergic Rhinitis: In some cases, Hydryllin DM syrup may be used off-label for the symptomatic relief of allergic rhinitis. It can help reduce nasal congestion, sneezing, and coughing caused by allergies.
3. Postnasal Drip: Hydryllin DM syrup may be used off-label to alleviate symptoms of postnasal drip, which is the sensation of mucus dripping down the back of the throat. It can help reduce coughing and throat irritation associated with excessive mucus production.
4. Asthma: In certain situations, Hydryllin DM syrup may be used off-label as part of the treatment regimen for asthma. It can help relieve coughing and promote the clearance of mucus from the airways.

Hydrylline DM Syrup is one of the leading brands with the combination of Diphenhydramine and Dextromethorphan in oral liquid form. Hydryllin DM syrup is manufactured and marketed by Searle Pakistan (Pvt) Ltd.

The following are Some Alternative Brands of Hydryllin DM Syrup and Their Manufacturers.

• Benylin-DM : Pfizer Laboratories Inc.
• Broxol-DM : Stanley Pharmaceuticals (Pvt) Ltd, Pakistan.
• Torax-DM : Siza International (Pvt) Ltd, Pakistan.
• Biollin DM : Bio Labs (Pvt) Ltd, Pakistan.
• Orolin-DM : Don Valley Pharmaceuticals (Pvt) Ltd, Pakistan.
• Tuscolin-D : Helix Pharma (Pvt) Ltd, Pakistan.
• Bronchosafe : Safe Pharmaceutical (Pvt) Ltd, Pakistan.
• Xatus D : Asian Agencies, Pakistan.
• Nafraline-DM : Nafar Pharmaceuticals Lab (Pvt) Ltd, Pakistan.
• Respirate-DM : Xenon Pharmaceuticals (Pvt) Ltd, Pakistan.

Presently, Hydryllin is available in Syrup Form.

Hydryllin DM Syrup Each 5ml Contains:

• Diphenhydramine HCL: 5mg
• Dextromethorphan Hydrobromide: 6.25mg

Hydryllin Syrup Each 5ml Contains:

• Aminophylline: 32mg
• Diphenhydramine Hcl: 8mg
• Ammonium Chloride: 30mg
• Menthol: 0.98mg

Hydryllin DM syrup has certain contraindications, meaning there are situations where its use should be avoided due to potential risks or adverse effects.

1. Hypersensitivity: Hydryllin DM syrup should not be used in individuals who have a known hypersensitivity or allergic reaction to any of its active ingredients, including diphenhydramine, ammonium chloride, or bromhexine.
2. Asthma and Chronic Obstructive Pulmonary Disease (COPD): Hydryllin DM syrup is contraindicated in individuals with asthma or COPD, as it can potentially worsen bronchospasm and respiratory distress in these conditions.
3. Severe Liver or Kidney Impairment: Hydryllin DM syrup should be used with caution or avoided in individuals with severe liver or kidney impairment, as the medication’s clearance may be reduced, leading to potential accumulation and increased risk of adverse effects.
4. Peptic Ulcer Disease: Hydryllin DM syrup should be used with caution in individuals with peptic ulcer disease, as it can potentially worsen gastrointestinal symptoms or interfere with ulcer healing.
5. Closed-Angle Glaucoma: Hydryllin DM syrup is contraindicated in individuals with closed-angle glaucoma, a condition characterized by increased intraocular pressure, as it can potentially worsen the condition.
6. Concurrent Use of Monoamine Oxidase Inhibitors (MAOIs): Hydryllin DM syrup should not be used in individuals taking or within 14 days of discontinuing MAOIs, as it can lead to severe drug interactions and adverse effects.

Hydryllin DM Syrup Dose for Children (6 to 12 years):

• 5 ml every 6 to 8 hours, up to a maximum of 20 ml in 24 hours.

Hydryllin DM Syrup Dose for Adults and Children (12 years and older):

• 10 ml every 6 to 8 hours, up to a maximum of 40 ml in 24 hours.

Diphenhydramine and dextromethorphan are two active ingredients commonly found in Hydryllin DM Syrup. They have distinct modes of action:

Diphenhydramine: Diphenhydramine is an antihistamine with additional antitussive properties. Its mode of action involves:

• Antihistamine Effect: Diphenhydramine works by blocking the effects of histamine, a chemical released during an allergic reaction. By binding to histamine receptors, particularly H1 receptors, it helps to reduce symptoms such as sneezing, itching, runny nose, and watery eyes associated with allergies.
• Antitussive Effect: Diphenhydramine also acts as a cough suppressant by inhibiting the cough reflex in the brain. It works by reducing the sensitivity of the cough center, providing temporary relief from coughing.

Dextromethorphan: Dextromethorphan is a cough suppressant and belongs to a class of medications called antitussives. Its mode of action involves:

• NMDA Receptor Antagonism: Dextromethorphan acts as a non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptors in the brain. By blocking NMDA receptors, it reduces the transmission of cough signals in the central nervous system, resulting in decreased coughing.
• Sigma-1 Receptor Agonism: Dextromethorphan also has an affinity for sigma-1 receptors, which are located in various regions of the brain. Activation of sigma-1 receptors may contribute to the antitussive effects of dextromethorphan, although the exact mechanism is not fully understood.