Hitop Tablet Uses

Hitop tablet is primarily used for the treatment of epilepsy and migraine prevention. It belongs to the class of drugs known as anticonvulsants or antiepileptic drugs. Following are some approved and off-label uses of Hitop Tablet:

Approved Uses of Hitop Tablet

1. Epilepsy: Hitop tablet is used as an antiepileptic drug in the treatment of various types of seizures, including partial-onset seizures and generalized tonic-clonic seizures, both in adults and children.
2. Migraine Prevention: Hitop tablet is also used for migraine prophylaxis. It reduces the frequency and severity of migraine headaches in adults.

Off-label Uses of Hitop Tablet

1. Weight Loss: Hitop tablets are sometimes used off-label as an adjunctive treatment for weight loss in individuals who are overweight or obese. It is used in combination with lifestyle modifications and a calorie-restricted diet.
2. Bipolar Disorder: Hitop tablets may be used as an adjunctive treatment for bipolar disorder. It can help stabilize mood and reduce the frequency and intensity of manic or depressive episodes.
3. Neuropathic Pain: In some cases, Hitop tablets may be used for the management of certain types of neuropathic pain, such as diabetic neuropathy or postherpetic neuralgia.

Hitop is one of the leading brands of Topiramate, manufactured and marketed by Hilton Pharmaceuticals (Pvt) Ltd, Pakistan.

Following are some available similar brands that can be used as an alternative to Hitop:

• Torate : (CCL) Consolidated Chemical Laboratories (Pvt) Ltd, Pakistan
• Topirama : Platinum Pharmaceuticals (Pvt) Ltd, Pakistan.
• Toprate : Horizon Pharmaceuticals (Pvt) Ltd, Pakistan.
• Legent : Amarant Pharmaceuticals (Pvt) Ltd, Pakistan.
• Topiro : Adamjee Pharmaceuticals (Pvt) Ltd, Pakistan.
• Topagen : Genetics Pharmaceuticals, Pakistan.
• Zopiramate : Mass Pharma (Pvt) Ltd, Pakistan.
• Topamax : Janssen-Cilag.
• Amtec : Sharooq Pharmaceuticals, Pakistan.
• Topmate : Efrozw Chemical Industries (Pvt) Ltd, Pakistan.

Presently, Hitop is available in Tablet Form with the following strengths.

Hitop Tablets : 25mg, 50mg, and 100mg strengths.

While Hitop is generally well-tolerated, there are certain contraindications and precautions that should be considered before using Hitop tablets.

Hypersensitivity: Hitop should not be used in individuals who have a known hypersensitivity or allergy to the drug or any of its components. Allergic reactions can range from mild skin rashes to more severe reactions like Stevens-Johnson syndrome.

Metabolic Acidosis: Hitop can cause a condition called metabolic acidosis, characterized by an increase in the acidity of the blood. It is contraindicated in individuals with metabolic acidosis or conditions that predispose them to metabolic acidosis, such as kidney problems or certain respiratory disorders.

Pregnancy: Hitop is classified as a pregnancy category D drug. It has been associated with an increased risk of birth defects, such as cleft lip and palate when taken during pregnancy. It should not be used in women who are pregnant or planning to become pregnant unless the potential benefits outweigh the risks.

Alcohol use: Hitop can increase the sedative effects of alcohol, so it is generally advised to avoid or limit alcohol consumption while using Hitop tablets.

Kidney stones: Hitop can increase the risk of developing kidney stones. Individuals with a history of kidney stones or conditions that predispose them to kidney stone formation may require close monitoring or alternative treatment options.

Glaucoma: Hitop can cause an increase in intraocular pressure and is contraindicated in individuals with narrow-angle glaucoma. Regular eye examinations are recommended for individuals taking Hitop.

Hitop Dose for Epilepsy:

• One tablet of 25mg is taken orally once daily.
• The dose may be increased gradually every 1 to 2 weeks from 25mg to 50mg.
• The maximum recommended dose is 2 tablets of 100mg two times a day.

Hitop Dose for Migraine Prophylaxis:

• Starting dose for adults is usually One tablet of 25mg taken orally at night.
• The dose may be increased gradually by 25 mg per week.
• The maximum recommended dose is One tablet of 50mg two times a day.

Hitop Dose for Weight Loss:

• When used as an adjunctive treatment for weight loss, It is typically started at a low dose (e.g., one tablet of 25mg) and increased gradually, under medical supervision, to a maximum dose of two tablets of 100mg per day.

The exact mode of action of Hitop is not fully understood, but it is believed to involve multiple mechanisms.

1. Enhancement of GABA activity: Hitop enhances the activity of gamma-aminobutyric acid (GABA), which is an inhibitory neurotransmitter in the brain. It may increase the inhibitory effects of GABA by binding to specific GABA receptors or by increasing the release of GABA.
2. Inhibition of excitatory neurotransmitters: Hitop may inhibit the activity of excitatory neurotransmitters, such as glutamate. It is thought to block glutamate receptors, particularly the AMPA/kainate subtype, and thereby reduce excitatory neurotransmission.

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