Gabica Tablet Uses

Gablica is primarily used to treat neuropathic pain caused by various medical conditions. It belongs to the class of drugs known as anticonvulsants. Gabica can also used for other neurological conditions, including seizures and anxiety. Following are some common and off-label uses of Gabica:

Common Uses of Gabica

1. Neuropathic Pain: Gabica is approved for the treatment of neuropathic pain, which is caused by damage to the nerves. Gabica is commonly used to treat pain associated with conditions such as diabetic neuropathy, postherpetic neuralgia, and spinal cord injury.
2. Epilepsy: Gabica is also used as an adjunctive therapy (along with other medications) in the treatment of partial seizures in adults with epilepsy.
3. Generalized Anxiety Disorder: Gabica is approved for the treatment of generalized anxiety disorder (GAD), a condition characterized by persistent and excessive worry and anxiety.
4. Fibromyalgia: Gabica is also sometimes used to treat fibromyalgia, a chronic pain disorder characterized by widespread musculoskeletal pain, fatigue, and tenderness in localized areas.

Off-label Uses of Gabica

1. Chronic Pain Conditions: Gabica has been used off-label to manage chronic pain conditions beyond neuropathic pain, such as chronic low back pain, chronic migraine, and pain associated with conditions like rheumatoid arthritis.
2. Insomnia and Sleep Disorders: Gabica may be used off-label to treat insomnia and certain sleep disorders.
3. Social Anxiety Disorder: Gabica has been used for treating social anxiety disorder (social phobia) as an off-label use.
4. Bipolar Disorder: Gabica may be used in the management of bipolar disorder, particularly in the treatment of bipolar depression.
5. Alcohol Withdrawal: Gabica can also used to manage alcohol withdrawal symptoms.

Gabica is one of the leading brands of Pregabalin, manufactured and marketed by Getz Pharma, Pakistan.

The following are some alternative brands of Gabica and their manufacturers.

• Zeegap : Hilton Pharmaceuticals, Pakistan.
• Lyrica : Pfizer Laboratories Ltd.
• Pegalin : Shaigan Pharmaceuticals (Pvt) Ltd, Pakistan.
• Syngab : Atco Laboratories, Pakistan.
• Gablin : Consolidated Chemical Laboratories (CCL), Pakistan.
• Pregy : Sami Pharmaceuticals (Pvt) Ltd, Pakistan.
• Regab : Caraway Pharmaceuticals, Pakistan.
• Xaar : Wilshire Laboratories (Pvt) Ltd, Pakistan.
• Hilin : Highnoon Laboratories, Pakistan.
• Megab : Sante (Pvt) Ltd, Pakistan.
• Breglin : Brooks Pharmaceuticals, Pakistan.

Presently, Gabica is available in Capsules form

Gabica : 50mg, 75mg, 100mg, 150mg, and 300mg strengths

Gabica is a safe and effective medication for most people, but it is important to be aware of the potential contraindications before taking it.

• Allergic Reactions to Gabica: Individuals with a known hypersensitivity or allergic reaction to Gabica or its components should avoid its use. Allergic reactions can manifest as rashes, itching, swelling, or difficulty breathing and require immediate medical attention.
• Heart Problems: Gabica may exacerbate certain heart conditions. Individuals with a history of heart problems, including heart failure, should exercise caution, and usage should be closely monitored under the supervision of a healthcare professional.
• Kidney Issues: Gabica is primarily excreted through the kidneys. Individuals with impaired kidney function may require dose adjustments or, in severe cases, may be advised against using Gabica to prevent the risk of accumulation and potential toxicity.
• History of Substance Abuse: Gabica has the potential for abuse or dependence. Individuals with a history of substance abuse, including alcohol or drugs, may be at an increased risk. Healthcare providers should carefully assess the risk-benefit profile before prescribing.
• Suicidal Ideation and Mental Health Concerns: Gabica is associated with an increased risk of suicidal thoughts and behaviors. Individuals with a history of mental health issues, including depression and suicidal tendencies, may require close monitoring, and the use of Gabica should be approached with caution.
• Pregnancy and Breastfeeding: While evidence on the safety of Gabica during pregnancy is limited, it is generally advised to avoid its use unless the potential benefits outweigh the risks. Gabica may also pass into breast milk and its use while breastfeeding should be discussed with a healthcare provider.
• Geriatric Population: Elderly individuals may be more sensitive to the effects of Gabica. Factors such as reduced kidney function and the presence of other medical conditions should be carefully considered when prescribing Gabica to older adults.
• Driving and Operating Heavy Machinery: Gabica can cause dizziness and drowsiness. Individuals engaging in activities that require alertness, such as driving or operating heavy machinery, should exercise caution. Any impairment in cognitive or motor skills should be reported to healthcare providers.

Gabica Dose for Diabetic Peripheral Neuropathy: one capsule of 50mg and can be increased to one capsule of 100mg.

Gabica Dose for Postherpetic Neuralgia: one capsule of 50mg and can be increased to one capsule of 100mg.

Gabica Dose for Partial-Onset Seizures: 300-600 mg per day divided into two doses.

Gabica Dose for Generalized Anxiety Disorder: 150-600 mg per day split into two doses when used as an adjunct therapy.

Gabica Dose for Fibromyalgia: 75-450 mg per day divided into three doses.

Gabica Dose for Social Anxiety Disorder: 300-450 mg per day divided into three doses when used as an adjunct treatment option.

Gabica Dose for Alcohol Withdrawal Syndrome: 50–150mg taken twice daily.

Gabica Dose for Opioid Withdrawal Syndrome: 100–300mg taken every 6 hours.

When the a need for discontinuation, Gabica Should taper off gradually within a minimum of one week.

Gabica works by binding to the alpha-2-delta (α2δ) subunit of voltage-gated calcium channels in the central nervous system. This binding reduces the release of several excitatory neurotransmitters, including glutamate, substance P, norepinephrine, and calcitonin gene-related peptide (CGRP). By reducing the release of these excitatory neurotransmitters, Gabica can help to reduce neuronal excitability and improve symptoms of neuropathic pain, seizures, and fibromyalgia.

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