Dolgina Capsule Uses

Dolgina capsule is primarily used to treat certain conditions related to excessive stomach acid production. It belongs to a class of drugs known as proton pump inhibitors (PPIs). Following are some common and off-label uses of Dolgina Capsules:

Common Uses of Dolgina Capsule

1. Treatment of Gastroesophageal Reflux Disease (GERD): Dolgina is commonly used to manage the symptoms of GERD, a condition where stomach acid flows backward into the esophagus, causing heartburn, regurgitation, and other symptoms. It reduces the production of stomach acid helps alleviate these symptoms and promotes the healing of the esophagus.
2. Healing and Maintenance of Erosive Esophagitis: Dolgina is effective in treating erosive esophagitis, a condition characterized by the inflammation and erosion of the lining of the esophagus due to prolonged exposure to stomach acid. Dolgina is used in the healing of these erosions and helps maintain remission.
3. Gastric Ulcers: Dolgina is used for the healing and prevention of gastric ulcers, which are open sores that develop in the lining of the stomach. Using Dolgina capsules reduces stomach acid production, allowing the ulcers to heal and preventing their recurrence.
4. Nonsteroidal Anti-Inflammatory Drug (NSAID)-Associated Gastric Ulcers: Dolgina may be used to reduce the risk of developing gastric ulcers associated with the use of nonsteroidal anti-inflammatory drugs (NSAIDs), which are commonly used to manage pain and inflammation. It helps to protect the stomach lining from the damaging effects of NSAIDs.
5. Zollinger-Ellison Syndrome: Dolgina is used for the long-term treatment of Zollinger-Ellison syndrome, a rare condition characterized by excessive acid production in the stomach due to a tumor called gastrinoma. By inhibiting acid secretion, it helps manage the symptoms associated with this syndrome.

Off-label Uses of Dolgina Capsule

1. Laryngopharyngeal Reflux (LPR): LPR is a condition in which stomach acid refluxes into the throat, causing symptoms like hoarseness, throat clearing, and chronic cough. Although Dolgina is not specifically approved for LPR, it is sometimes used off-label to reduce acidity and alleviate symptoms in patients with this condition.
2. Prevention of Stress Ulcers: Stress ulcers can occur in critically ill patients, particularly those in intensive care units, as a result of physiological stress, trauma, or severe illness. Dolgina capsules may be used off-label to reduce the risk of stress ulcers in certain high-risk patients.
3. Treatment of Non-Ulcer Dyspepsia: Non-ulcer dyspepsia refers to chronic or recurrent indigestion symptoms, such as upper abdominal pain, bloating, and early satiety, without the presence of an identifiable ulcer or inflammation. Dolgina may be used in some cases to manage these symptoms by reducing gastric acid production.
4. H. pylori Eradication Therapy: Helicobacter pylori (H. pylori) is a bacterium that can cause gastritis, peptic ulcers, and other gastrointestinal conditions. In some cases, Dolgina may be used off-label in combination with antibiotics to help eradicate the H. pylori infection.

Dolgina is one of the leading brands of Dexlansoprazole, manufactured and marketed by Hiltin Pharmaceuticals (Pvt) Ltd, Pakistan.

Below are some available similar brands that can be used as an alternative to Dolgina capsules:

• Dexxoo : Horizon Pharmaceuticals (Pvt) Ltd, Pakistan.
• Delanzo DR : Sami Pharmaceuticals (Pvt) Ltd, Pakistan.
• Razodex : Getz Pharmaceuticals (Pvt) Ltd, Pakistan.
• DXL : Highnoon Laboratories (Pvt) Ltd, Pakistan.
• Dextop : Searle (Pakistan) Ltd.
• Exlant : Genix Pharmaceuticals (Pvt) Ltd, Pakistan.
• DDR : Macter Internation.
• Dexiva : Ferozsons Laboratories (Ltd) Pakistan.
• Dexila : Scilife Pharmaceuticals (Pvt) Ltd, Pakistan.
• Daplazole : AGP Pharmaceuticals (Pvt) Ltd, Pakistan.

Presently, Dolgina is available in only Capsule Form with the following strengths.

Dolgina Capsules : 30mg and 60mg strengths.

Dolgina has certain contraindications, which are specific situations or conditions in which the use of the medication is not recommended.

Hypersensitivity: Dolgina is contraindicated in individuals who have a known hypersensitivity or allergy to Dolgina or any of its components. Allergic reactions can range from mild skin rashes to more severe reactions, such as difficulty breathing or anaphylaxis.

Concomitant Use with Certain Medications: Dolgina may interact with certain medications, affecting their effectiveness or increasing the risk of adverse effects. Therefore, it is contraindicated to use Dolgina with drugs such as Atazanavir and Nelfinavir, which require a certain level of gastric acidity for proper absorption.

Severe Liver Impairment: Dolgina is primarily metabolized in the liver. Individuals with severe liver impairment may have a reduced ability to metabolize the drug, leading to higher drug levels in the body. Dolgina is contraindicated in such cases due to an increased risk of adverse effects.

Pregnancy and Breast-feeding: The safety of Dolgina during pregnancy and breastfeeding has not been established conclusively. As a precautionary measure, it is generally recommended to avoid the use of Dolgina during pregnancy and breastfeeding unless the potential benefits outweigh the risks.

Children: Dolgina is not approved for use in children younger than 12 years old. The safety and efficacy of Dolgina in this age group have not been established.

Dolgina Dose for Healing and Maintenance of Erosive Esophagitis:

• Initial Dose: One capsule of 60mg once daily for up to 8 weeks.
• Maintenance Dose: One Capsule of 30mg once daily may be used to prevent the recurrence of erosions.

Dolgina Dose for Symptomatic Relief of Gastroesophageal Reflux Disease (GERD):

• One Capsule of 30mg once daily for up to 4 weeks.

Dolgina Dose for Gastric Ulcers:

• One Capsule of 30mg once daily for up to 6 weeks.

Dolgina Dose for Zollinger-Ellison Syndrome:

• One Capsule of 60mg.
• The dose may be adjusted based on individual response and can range from one to two capsules of 60mg per day.

Dolgina is a proton pump inhibitor (PPI) that works by reducing the production of stomach acid. Its mode of action involves selectively and irreversibly inhibiting the hydrogen/potassium adenosine triphosphatase (H+/K+ ATPase) enzyme, also known as the gastric proton pump, in the parietal cells of the stomach.

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