Diampa Tablet Uses

Diampa tablet belongs to a class of drugs called sodium-glucose co-transporter 2 (SGLT2) inhibitors. It is primarily used in the treatment of type 2 diabetes mellitus to help control blood sugar levels. The following are some common uses of Diampa Tablet:

1. Type 2 Diabetes: Diampa tablet is used for adults with type 2 diabetes as an adjunct to diet and exercise to improve glycemic control. It helps lower blood glucose levels by inhibiting the reabsorption of glucose in the kidneys, resulting in increased urinary excretion of glucose.
2. Cardiovascular Risk Reduction: Diampa tablet has been shown to have additional benefits beyond blood sugar control. Clinical trials have demonstrated that it can significantly reduce the risk of major cardiovascular events, including heart attack, stroke, and cardiovascular death, in patients with type 2 diabetes and established cardiovascular disease.
3. Heart Failure: Diampa tablet has been found to be beneficial in the treatment of heart failure with reduced ejection fraction (HFrEF). It helps improve symptoms, reduces the risk of hospitalization due to heart failure, and decreases the risk of cardiovascular death in patients with this condition, regardless of whether they have diabetes or not.
4. Renal Protection: Using Diampa tablet slows the progression of chronic kidney disease (CKD) and reduces the risk of end-stage renal disease (ESRD) in patients with type 2 diabetes and established cardiovascular disease or multiple cardiovascular risk factors.

Off-label Uses of Diampa Tablet

1. Polycystic Ovary Syndrome (PCOS): Diampa tablets may be beneficial in women with PCOS. It may help improve insulin resistance, promote weight loss, and regulate menstrual cycles. However, more research is needed to establish its efficacy and safety in this context.
2. Non-Alcoholic Fatty Liver Disease (NAFLD): Diampa tablets may be used off-label for liver health in patients with NAFLD. It may help reduce liver fat accumulation and improve liver enzyme levels.
3. Obesity: Diampa tablet’s ability to promote weight loss, primarily through increased urinary excretion of glucose and associated calorie loss, has led to its investigation as a potential treatment for obesity. However, its use in this context is still being evaluated, and more research is needed to establish its safety and efficacy.

Diampa is one of the leading brands of Empagliflozin, manufactured and marketed by Getz Pharmaceuticals (Pvt) Ltd, Pakistan.

The following are some alternative brands of Diampa and their manufacturers.

• Jardy : (CCL) Consolidated Chemical Laboratories (Pvt) Ltd, Pakistan.
• Xenglu : Hilton Pharmaceuticals (Pvt) Ltd, Pakistan.
• Diajard : Highnoon Pharmaceutical Laboratories (Pvt) Ltd, Pakistan.
• Empaa : Horizon Pharmaceuticals (Pvt) Ltd, Pakistan.
• Boschempa : Bosch Pharmaceuticals (Pvt) Ltd, Pakistan.
• Erli : Pharmevo Pakistan (Pvt) Ltd.
• Empoli : Sami Pharmaceuticals (Pvt) Ltd, Pakistan.
• Emglif : Genix Pharmaceuticals (Pvt) Ltd, Pakistan.
• Emsyn : Searle Pakistan Ltd.
• Empadon : Don Valley Pharma, Pakistan.
• Jardiance : Boehringer Ingelheim.

Presenly, Diampa is available in Tablet Form with the following Strengths.

Diampa Tablets : 10mg and 25mg strengths.

Diampa has certain contraindications, which means there are circumstances or medical conditions in which its use is not recommended.

• Hypersensitivity: Diampa is contraindicated in individuals who have a known hypersensitivity or allergy to Diampa or any of its components. If an allergic reaction occurs, such as rash, itching, or difficulty breathing, medical attention should be sought immediately.
• Severe renal impairment or end-stage renal disease: Diampa is not recommended for individuals with severe renal impairment (estimated glomerular filtration rate [eGFR] less than 30 mL/min/1.73 m²) or end-stage renal disease, including patients on dialysis. This is because Diampa’s mechanism of action relies on renal excretion, and impaired kidney function may hinder its effectiveness and increase the risk of adverse effects.
• Diabetic ketoacidosis (DKA): Diampa should not be used in the treatment of diabetic ketoacidosis, a serious complication of diabetes characterized by high blood sugar levels, ketones in the urine, and metabolic acidosis. It is important to manage DKA with appropriate medical interventions, such as insulin therapy and intravenous fluids.
• Type 1 diabetes: Diampa is indicated for the treatment of type 2 diabetes only and should not be used in individuals with type 1 diabetes. Type 1 diabetes is a condition where the body does not produce insulin, and Diampa’s mechanism of action primarily targets glucose reabsorption in the kidneys, which may not be effective in type 1 diabetes.
• Pregnancy and breast-feeding: The use of Diampa during pregnancy is not recommended, as there is limited data on its safety in pregnant women. It is also not known whether Diampa is excreted in human breast milk, so caution should be exercised when considering its use during breastfeeding.

Typically, the standard recommended dose for Diampa is one tablet of 10mg once daily.

Diampa Dose for Type 2 Diabetes:

• Starting Dose: One Tablet of 10mg once daily.
• The dose can be increased to 25mg tablet once daily if additional glycemic control is needed.
• It can be taken with or without food.

Diampa Dose for Heart failure with reduced ejection fraction:

• One Tablet of 10mg once daily.
• It can be taken with or without food.

Diampa Dose for Renal Function:

• If a person has moderate to severe renal impairment (estimated glomerular filtration rate [eGFR] below 45 mL/min/1.73 m²), the dose may be reduced to 10mg every other day (10mg tablet once in 48 hours) or even discontinued if the eGFR falls below 30 mL/min/1.73 m².

Diampa Dose Tolerability:

• Depending on an individual’s response and tolerance to the medication, a healthcare professional may consider increasing the dose to a maximum of 25mg once daily.

Diampa works by selectively inhibiting the SGLT2 protein in the renal tubules. By doing so, it reduces the reabsorption of glucose from the renal tubules back into the bloodstream. This action allows excess glucose to be excreted from the body through the urine, resulting in lower blood glucose levels.