Dextop Capsule Uses

Dextop Capsules are primarily used for the treatment of certain conditions related to excessive stomach acid production. It belongs to a class of drugs known as proton pump inhibitors (PPIs). Following are some common uses of Dextop Capsule:

1. Gastroesophageal Reflux Disease (GERD): Dextop is used to manage the symptoms of GERD, such as heartburn, acid regurgitation, and difficulty swallowing.
2. Erosive Esophagitis: Dextop capsules are used to heal and prevent further damage to the esophagus caused by stomach acid, which can occur in conditions like GERD.
3. Non-Erosive Reflux Disease: Dextop may be prescribed for individuals with non-erosive reflux disease (NERD), a condition characterized by typical GERD symptoms without visible esophageal damage.
4. Gastric Ulcers: Using Dextop capsules can help in the treatment of gastric ulcers, which are open sores that develop on the lining of the stomach.
5. Duodenal Ulcers: Dextop is also used for the treatment of duodenal ulcers, which are ulcers that occur in the upper part of the small intestine.
6. Zollinger-Ellison Syndrome: Dextop may be prescribed for individuals with Zollinger-Ellison syndrome, a rare condition where excessive stomach acid is produced, leading to ulcers in the digestive system.

Off-label Uses of Dextop Capsule

1. Non-Ulcer Dyspepsia: Non-ulcer dyspepsia, also known as functional dyspepsia, is a condition characterized by recurring indigestion or pain in the upper abdomen without any underlying structural cause. Dextop can be used as an off-label treatment option for managing the symptoms of non-ulcer dyspepsia.
2. Gastroparesis: Gastroparesis is a condition characterized by delayed stomach emptying. Dextop might be used to manage symptoms associated with gastroparesis.
3. Prevention of Nonsteroidal Anti-inflammatory Drugs (NSAID)-Induced Ulcers: NSAIDs can cause irritation and ulcers in the stomach and intestines. Dextop has been used to reduce the risk of developing ulcers in individuals who require long-term NSAID therapy.
4. Laryngopharyngeal Reflux (LPR): LPR is a condition where stomach acid flows back into the throat, causing symptoms such as hoarseness, chronic cough, and throat irritation. Dextop has been used to manage LPR symptoms by reducing the production of stomach acid.
5. Eosinophilic Esophagitis (EoE): EoE is a chronic allergic condition that causes inflammation in the esophagus. Dextop has been investigated as an off-label treatment option for EoE due to its acid-reducing effects, which may help alleviate symptoms.
6. Gastrointestinal Bleeding: Dextop has been used in the management of gastrointestinal bleeding to reduce gastric acid secretion and promote healing. However, other medications and interventions are typically considered first-line treatments for this condition.
7. Stress Ulcer Prophylaxis: Dextop has been used off-label to prevent stress-related ulcers in critically ill patients who are at high risk due to factors such as severe illness, trauma, or intensive care unit (ICU) stays.

Dextop is one of the leading brands of dexlansoprazole, manufactured and marketed by Searle (Pakistan) Ltd.

The following are some alternative brands of Dextop Capsules and their manufacturers.

• Dexxoo : Horizon Pharmaceuticals (Pvt) Ltd, Pakistan.
• Delanzo DR : Sami Pharmaceuticals (Pvt) Ltd, Pakistan.
• Razodex : Getz Pharmaceuticals (Pvt) Ltd, Pakistan.
• DXL : Highnoon Laboratories (Pvt) Ltd, Pakistan.
• Dolgina : Hilton Pharmaceuticals (Pvt) Ltd, Pakistan.
• Exlant : Genix Pharmaceuticals (Pvt) Ltd, Pakistan.
• DDR : Macter Internation.
• Dexiva : Ferozsons Laboratories (Ltd) Pakistan.
• Dexila : Scilife Pharmaceuticals (Pvt) Ltd, Pakistan.
• Daplazole : AGP Pharmaceuticals (Pvt) Ltd, Pakistan.

Presently, Dextop is available in Capsules Form.

Dextop Capsules : 30mg and 60mg strengths.

Dextop has certain contraindications, which are specific situations or conditions in which the use of Dextop Capsule is not recommended.

Hypersensitivity: Dextop is contraindicated in individuals who have a known hypersensitivity or allergic reaction to Dextop or any of its components.

Severe Liver Disease: Individuals with severe liver disease, such as liver failure, are generally advised against using Dextop due to the potential impact on liver function.

Severe Kidney Disease: Dextop may not be recommended for individuals with severe kidney disease as it can affect the elimination of the medication from the body.

Concurrent Use with Rilpivirine-Containing Products: Dextop should not be used concomitantly with rilpivirine-containing products, as Dextop can decrease the blood levels of rilpivirine, reducing its effectiveness.

Clostridium difficile Infection: Dextop is generally not recommended for individuals with an active Clostridium difficile infection, a bacterial infection that affects the colon.

Osteoporosis: Long-term and high-dose use of Dextop, may be associated with a slightly increased risk of fractures, particularly in older individuals or those with osteoporosis. It is important to assess the risks and benefits of Dextop use in such cases.

Dextop Capsules Dose for Gastroesophageal Reflux Disease (GERD) and Erosive Esophagitis:

• Healing of Erosive Esophagitis: One Capsule of 60 mg once daily for up to 8 weeks.
• Maintenance of Healed Erosive Esophagitis: One Capsule of 30 mg once daily.

Dextop Capsules Dose for Non-Erosive Reflux Disease (NERD):

• Symptomatic NERD: One Capsule of 30 mg once daily for 4 weeks.

Dextop Capsules Dose for Gastric and Duodenal Ulcers:

• Gastric Ulcer: One Capsule of 30 mg once daily for 4-8 weeks.
• Duodenal Ulcer: One Capsule of 30 mg once daily for 2 weeks.

Dextop Capsules Dose for Zollinger-Ellison Syndrome and Other Hypersecretory Conditions:

• One Capsule of 60 mg once daily. The dose can be adjusted based on individual patient needs.

Dextop capsule’s mode of action involves reducing the production of stomach acid by inhibiting the enzyme called H+/K+-ATPase, which is also known as the gastric proton pump.

Dextop Works by:

• Binding to the Enzyme (H+/K+-ATPase)
• Inhibition of Proton Pump
• Reduction in Acid Secretion

Related Links:

Dextop Side Effects