Dapa Tablet Uses

Dapa tablet is primarily used in the management of type 2 diabetes mellitus. It belongs to a class of drugs known as sodium-glucose co-transporter 2 (SGLT2) inhibitors. Following are some common uses of Dapa Tablet:

1. Type 2 Diabetes: Dapa tablet is used for the treatment of type 2 diabetes as an adjunct to diet and exercise. It helps lower blood glucose levels by blocking the reabsorption of glucose in the kidneys, leading to increased glucose excretion in the urine.
2. Glycemic Control: Dapa tablets, when used along with proper diet and exercise, can help improve glycemic control in individuals with type 2 diabetes. It is often prescribed when other oral antidiabetic medications, such as metformin, fail to achieve adequate blood glucose control.
3. Cardiovascular Benefits: Dapa tablet provides cardiovascular benefits in patients with type 2 diabetes. It has been shown to reduce the risk of major adverse cardiovascular events, including heart attack, stroke, and cardiovascular death, in patients with established cardiovascular disease.
4. Weight Loss: Dapa tablets can lead to modest weight loss in individuals with type 2 diabetes. This is attributed to the increased urinary excretion of glucose, which causes a loss of calories.
5. Blood Pressure Control: Dapa tablet has been found to have a blood pressure-lowering effect. It can help reduce systolic and diastolic blood pressure in patients with type 2 diabetes, which is beneficial for individuals with hypertension.

Off-label Uses of Dapa Tablet

1. Type 1 Diabetes: Dapa tablet is being used as an adjunct therapy for type 1 diabetes. While it is not currently approved for this use, it may help improve glycemic control and reduce insulin requirements in certain individuals with type 1 diabetes.
2. Chronic Kidney Disease (CKD): Dapa tablet is being used as a potential treatment for chronic kidney disease, particularly in patients with type 2 diabetes. It can slow the progression of kidney disease and reduce the risk of kidney failure.
3. Non-alcoholic Fatty Liver Disease (NAFLD): Dapa tablets may be used off-label for non-alcoholic fatty liver disease. It may help improve liver function, reduce liver fat content, and decrease markers of liver inflammation.
4. Polycystic Ovary Syndrome (PCOS): Dapa tablet is used as a potential treatment option for women with polycystic ovary syndrome. It may help improve insulin sensitivity, regulate menstrual cycles, and reduce weight in women with PCOS.

Dapa is one of the leading brands of Dapagliflozin, manufactured and marketed by Hilton Pharmaceuticals (Pvt) Ltd, Pakistan.

The following are some alternative brands of Dapa and their manufacturers.

• Xiga : (CCL) Consolidated Chemical Laboratories (Pvt) Ltd, Pakistan.
• Dapaloz : Highnoon Laboratories (Pvt) Ltd, Pakistan.
• Daplyza : Getz Pharmaceuticals (Pvt) Ltd, Pakistan.
• Dapwiz : Pharmevo Pakistan (Pvt) Ltd.

Presently, Dapa is available in Tablet Form with the following strengths.

Dapa Tablets : 5mg and 10mg strengths.

Dapa has certain contraindications, which are medical conditions or situations where the use of Dapa is not recommended due to the potential risks outweighing the benefits.

Hypersensitivity: Dapa is contraindicated in individuals who have a known hypersensitivity or allergy to Dapa or any of its components. Allergic reactions can range from mild skin reactions to severe allergic reactions, including anaphylaxis, which is a potentially life-threatening condition.

Severe Renal Impairment or End-Stage Renal Disease: Dapa is contraindicated in patients with severe renal impairment (estimated glomerular filtration rate [eGFR] less than 30 mL/min/1.73 m²) or end-stage renal disease, including those on dialysis. Dapa exerts its effects through the kidneys, and impaired renal function may increase the risk of adverse events.

Diabetic Ketoacidosis (DKA): Dapa is contraindicated in patients with a current or history of diabetic ketoacidosis, a serious condition characterized by high blood ketone levels. Dapa can increase the risk of DKA, especially in individuals with type 1 diabetes.

Pregnancy and Breastfeeding: Dapa is not recommended during pregnancy, as its safety and efficacy have not been established in pregnant women. It is also not recommended while breastfeeding, as it is not known whether Dapa is excreted in human milk or its effects on the nursing infant.

Dapa Dose for Tpye 2 Diabetes:

• One Tablet of 5mg once daily. However, in some cases, the dose may be increased to 10mg tablet once daily if additional glycemic control is needed and if the medication is well-tolerated.
• The maximum recommended daily dose is 10 mg.

Dapa Dose for Individuals with Moderate Renal Impairment:

• One Tablet of 5mg once daily.

Dapa works by inhibiting the action of SGLT2, which is a protein located in the proximal tubules of the kidneys. SGLT2 is responsible for reabsorbing glucose from the urine back into the bloodstream.