Canesten Tablet Uses

Canesten tablet is an antifungal medication used to treat a variety of fungal infections. It is specifically designed for the treatment of vaginal yeast infections, also known as vaginal candidiasis. The following are some common uses and indications of Canesten Tablet:

1. Treating Vaginal Yeast Infections: One of the primary use of Canesten vaginal tablets is the treatment of vaginal yeast infections, medically known as vaginal candidiasis. These infections can cause uncomfortable symptoms such as itching, burning, and unusual discharge. Canesten’s antifungal properties combat the underlying cause of these infections effectively.
2. Balancing Vaginal Microflora: Maintaining a healthy balance of microflora in the vaginal area is crucial for women’s reproductive health. Canesten can help in achieving this balance by eliminating excess yeast growth, preventing recurrent infections, and promoting overall vaginal health.
3. Preventing Recurrent Infections: Recurrent vaginal yeast infections can be a recurring nuisance for some women. Canesten vaginal tablets can serve as a preventive measure, reducing the likelihood of future infections when used as prescribed.
4. Addressing Vaginal Itching and Discomfort: Vaginal itching and discomfort can be caused by various factors, including infections and allergies. Canesten’s soothing effect can provide relief from these uncomfortable symptoms, making it an invaluable choice for those experiencing such issues.
5. Treating Bacterial Vaginosis: While primarily an antifungal medication, Canesten has also shown promise in addressing bacterial vaginosis (BV). BV is characterized by an imbalance of bacteria in the vagina and can lead to symptoms like unusual discharge and odor. Canesten’s ability to combat this imbalance makes it a potential treatment option.
6. Supportive Role in Other Infections: In addition to its primary uses, Canesten vaginal tablets may offer support in managing other vaginal infections, especially when combined with other medications or therapies as prescribed by a healthcare provider.

Off-label Uses of Canesten Tablet

1. Prophylactic Use: In some cases, healthcare providers may prescribe Canesten vaginal tablets as a preventive measure against recurrent vaginal yeast infections in individuals who experience frequent episodes.
2. Bacterial Vaginosis (BV): While Canesten is an antifungal and is not typically used to treat bacterial infections, there have been instances where healthcare providers have prescribed it off-label for bacterial vaginosis. However, this is not a standard treatment, and other medications are usually preferred.
3. Cervical Dysplasia: The use of Canesten in combination with other treatments for cervical dysplasia, which is the presence of abnormal cells on the cervix. The rationale is that Canesten may have an antiproliferative effect on abnormal cells.
4. Vaginal Atrophy: Canesten has been trialed as a potential treatment for vaginal atrophy, a condition characterized by thinning and inflammation of the vaginal walls, often associated with menopause. It’s thought that Canesten tablet’s antifungal properties may help restore the vaginal flora.
5. Preoperative Use: There is some research suggesting that preoperative use of Canesten vaginal tablets may help reduce the risk of postoperative infections in certain gynecological procedures.
6. Vulvar Vestibulitis Syndrome (VVS): Canesten has been investigated as a potential treatment for VVS, a condition characterized by severe pain at the entrance to the vagina. Some studies have explored its use in combination with other treatments.

Canesten is one of the leading brands of Clotrimazole, manufactured and marketed by Bayer Schering Pharma.

The following are Some alternative brands of Canesten tablet and their manufacturers.

• Creamazole : Valor Pharmaceutical, Pakistan.
• Biotrim : Bio Labs (Pvt) Ltd, Pakistan.
• Cara-Clot : Caraway Pharmaceuticals, Pakistan.
• Clomazol : Pharmawise Labs. (Pvt) Ltd, Pakistan.
• Clonil Skin : Mediceena Pharma (Pvt) Ltd, Pakistan.
• Cloteen-V : Highnoon Laboratories Ltd, Pakistan.
• Clozim-6 : Stanley Pharmaceuticals (Pvt) Ltd, Pakistan.
• Clozox : Shaigan Pharmaceuticals (Pvt) Ltd, Pakistan.

Presently, Canesten is available in Tablet and Cream (Topical Use) forms.

• Canesten Tablet : 100mg and 500mg strengths.
• Canesten Cream : Clotrimazole 1%w/w and 10%w/w

Canesten tablets, like any medication, have specific contraindications, which are situations where the use of the medication is not recommended or should be avoided.

• Hypersensitivity: Individuals who have a known hypersensitivity or allergy to clotrimazole or any of the other ingredients in the Canesten tablet should not use it.
• First-time Vaginal Infections: Canesten vaginal tablets are typically recommended for women who have previously been diagnosed with a yeast infection. It is not usually the first-line treatment for an initial vaginal infection. In such cases, consulting a healthcare provider for proper diagnosis and treatment is important.
• Severe Vaginal Irritation or Injury: In cases of severe vaginal irritation or injury, using Canesten vaginal tablets may exacerbate the condition. It’s important to seek medical advice in such situations.
• Pregnancy: While Canesten is generally considered safe during pregnancy, it’s important to consult a healthcare provider before using any medication during pregnancy. They will weigh the benefits against potential risks.
• Children: Canesten vaginal tablets are typically not recommended for use in children. Special formulations and dosages may be prescribed for pediatric patients under the guidance of a healthcare provider.
• HIV Infection or Immunocompromised State: Individuals with HIV or other conditions that compromise the immune system should consult their healthcare provider before using Canesten vaginal tablets, as they may require additional considerations or alternative treatments.
• Undiagnosed Vaginal Discharge: If a woman has symptoms of a vaginal infection but has not been formally diagnosed, using Canesten vaginal tablets without a proper diagnosis is not advisable. A healthcare provider should assess the situation first.
• Active Sexually Transmitted Infections (STIs): If there is a suspicion of a sexually transmitted infection rather than a yeast infection, Canesten may not be the appropriate treatment. STIs require specific treatments, so a proper diagnosis is essential.

Precautions:

• Avoid Tampons during Treatment: While using Canesten vaginal tablets, it’s advised to avoid using tampons. Use sanitary pads instead.
• Avoid Vaginal Douching: Refrain from using vaginal douches during the course of treatment, as they can disrupt the natural balance of the vaginal flora.
• Refrain from Sexual Activity: It’s generally recommended to avoid sexual intercourse during treatment with Canesten vaginal tablets. If you do engage in sexual activity, the tablet may be pushed out of the vagina.
• Monitor for Adverse Effects: Pay attention to any signs of allergic reactions or other adverse effects. If you experience severe itching, rash, difficulty breathing, or swelling, seek immediate medical attention.
• Consult a Healthcare Provider: If symptoms persist or worsen after completing the treatment course, consult a healthcare provider for further evaluation and advice.

• Wash Hands: Before inserting the vaginal tablet, thoroughly wash your hands to ensure cleanliness.
• Choose a Comfortable Position: Find a comfortable position to insert the tablet. This may be lying down, standing with one leg raised, or sitting on the edge of a bed or toilet.
• Insert the Tablet: Gently insert one Canesten vaginal tablet as high into the vagina as possible using the applicator provided. The applicator helps ensure the tablet is placed properly.
• Wash Hands Again: After inserting the tablet, wash your hands again to maintain cleanliness.
• Use at Bedtime: It is recommended to insert the tablet at bedtime. This allows the tablet to dissolve and work overnight.
• Complete the Full Course: Follow the full course of treatment, even if symptoms improve before it is completed. This ensures that the infection is completely eradicated.

Canesten tablet works by inhibiting an enzyme (14-alpha demethylase) that is crucial for the synthesis of ergosterol. Without sufficient ergosterol, the fungal cell membrane becomes weakened and more permeable. By inhibiting ergosterol synthesis, Canesten causes structural abnormalities in the fungal cell membrane. This disruption weakens the membrane’s integrity, leading to the leakage of essential cellular components and ultimately cell death.