Brino Capsule Uses

Brino capsule is a medication that is primarily used to prevent or control excessive bleeding. It works by helping to maintain proper blood clotting. The following are some common uses and indications of Brino Capsule:

1. Menstrual bleeding: Brino capsule is often used in women who experience heavy menstrual bleeding (menorrhagia). It helps to reduce the amount of blood loss during menstrual periods.
2. Post-operative bleeding: After certain surgical procedures, especially those involving the nose, mouth, throat, or uterus, there can be a risk of excessive bleeding. Brino capsules may be prescribed to help control this bleeding.
3. Trauma and injury: Brino capsule may be used in situations where there is significant bleeding due to trauma or injury. It can be particularly helpful in cases of accidents or surgeries.
4. Nosebleeds (epistaxis): Brino capsule can be used to treat recurrent or severe nosebleeds, especially when other measures have failed.
5. Hereditary bleeding disorders: Individuals with certain hereditary bleeding disorders, such as hemophilia or von Willebrand disease, may be prescribed Brino capsules to help prevent or control bleeding episodes.
6. Tooth extraction: Brino capsules may be used in dentistry, especially after tooth extractions or oral surgery, to minimize bleeding.
7. Hemorrhage in pregnancy: In cases of significant bleeding during pregnancy, Brino capsule may be used in combination with other interventions to help control bleeding.
8. Bleeding associated with certain medical conditions: Brino capsules may be used in individuals with conditions that predispose them to bleeding, such as liver disease or certain types of leukemia.

Off-label Uses of Brino Capsule

1. Hemoptysis: Brino capsules may be used off-label for patients experiencing significant bleeding from the lungs.
2. Subarachnoid Hemorrhage: Some studies have investigated the use of Brino capsules in patients with subarachnoid hemorrhage, a type of bleeding in the space around the brain.
3. Heavy Uterine Bleeding due to Fibroids: Brino capsule has been studied for its potential to reduce heavy menstrual bleeding associated with uterine fibroids.
4. Hemorrhagic Stroke: In certain situations, Brino capsule may be considered as an adjunct treatment in cases of hemorrhagic stroke.
5. Bleeding in Cancer Patients: Brino capsules may be used in cancer patients who are at risk of bleeding due to thrombocytopenia (low platelet count) or other bleeding disorders.
6. Postpartum Hemorrhage: While this use is being studied and considered, it is not universally accepted as a standard treatment.

Brino is one of the leading brands of Tranexamic Acid, manufactured and marketed by Sami Pharmaceuticals (Pvt) Ltd, Pakistan.

The following are some alternative brands of Brino and their manufacturers.

• Zatranex : Zafa Pharmaceutical Laboratories (Pvt) Ltd, Pakistan.
• Transamin : Hilton Pharmaceuticals (Pvt) Ltd, Pakistan.
• Dravix : Getz Pharmaceuticals (Pvt) Ltd, Pakistan.
• Traxacid : Asian Continental Pharma, Pakistan.
• Btrol : Bocsh Pharmaceuticals (Pvt) Ltd, Pakistan.
• Maxna : AGP Pharma, Pakistan.
• Xed : Indus Pharma (Pvt) Ltd, Pakistan.
• Haematrix : Macter International (Pvt) Ltd, Pakistan.
• Hamic : Genix Pharmaceuticals (Pvt) Ltd, Pakistan.
• Hemsamic : Tabros Pharma, Pakistan.

Presently, Brino is available in capsule form.

• Brino Capsule : 250mg and 500mg strengths

Brino capsules, like any medication, have certain contraindications, which are situations where the use of the medication is not recommended or should be avoided.

1. Hypersensitivity: Individuals who have a known hypersensitivity or allergy to Tranexamic acid or any of the other ingredients in the capsule should not take it.
2. Active Thromboembolic Disease: Brino capsule is an antifibrinolytic agent, which means it helps prevent the breakdown of blood clots. Therefore, it should be avoided in individuals with active conditions like deep vein thrombosis (DVT), pulmonary embolism (PE), or other thromboembolic disorders.
3. Color Vision Deficiency: Brino capsule has been associated with rare cases of color vision disturbances. Therefore, it may not be suitable for individuals with pre-existing color vision deficiencies.
4. Seizure Disorders: Brino capsule has been reported to occasionally cause seizures, especially in high doses. It should be used with caution in individuals with a history of seizures or conditions that may increase the risk of seizures.
5. Renal Impairment: In cases of severe renal impairment or end-stage renal disease, dose adjustments may be necessary, and Brino capsule should be used with caution.
6. Subarachnoid Hemorrhage with Low Body Weight: Brino capsule should be used with caution in cases of subarachnoid hemorrhage, particularly in individuals with low body weight, as there may be an increased risk of cerebral edema.
7. Coronary Artery Disease: Brino capsules may not be suitable for individuals with a history of coronary artery disease, especially those with a recent myocardial infarction.
8. Concomitant Use with Tissue Plasminogen Activator (tPA): Brino capsules should not be used simultaneously with tPA or other thrombolytic agents, as they have opposing effects.
9. Pregnancy and Breastfeeding: The safety of Brino capsules during pregnancy and breastfeeding is not well-established. It should be used with caution, and the potential benefits should be weighed against potential risks.
10. Pediatric Use: Brino capsule capsules may not be recommended for use in children, especially in certain doses or for specific conditions. Pediatric dosing should be determined by a healthcare provider.

Brino Capsule Dose for Menstrual Bleeding (Menorrhagia):

• 1 – 2 Capsules of 500 mg (1 gram) taken three times a day for a duration of 4 to 5 days during menstrual periods.
• The first dose is often taken at the onset of bleeding.

Brino Capsule Dose for Post-operative Bleeding:

• The dosage can vary based on the type of surgery and the risk of bleeding.
• Two capsules of 500 mg (1 gram), taken before surgery.
• Followed by: 1 gram (2 capsules of 500mg) taken 6 hours after the initial dose, and then 1 gram taken 12 hours after the initial dose.

Brino Capsule Dose for Trauma and Injury:

• The dosage and duration may vary depending on the severity of bleeding and the specific circumstances. It is typically determined by a healthcare provider.

Brino Capsule Dose for Nosebleeds (Epistaxis):

• Two capsules of 500 mg (1 gram), taken three times a day for a short duration (e.g., 2 to 7 days).

Brino Capsule Dose for Dental Procedures:

• The dosage may vary depending on the specific procedure and risk of bleeding.
• It is typically determined by the treating dentist or oral surgeon.

Brino Capsule Dose for Other Off-Label Uses:

• The dosage for off-label uses can vary widely depending on the specific condition being treated.
• It is determined by a healthcare provider based on the available evidence and the individual patient’s needs.

Brino capsule exerts its therapeutic effect through its antifibrinolytic properties. Fibrinolysis is a natural process in the body where blood clots dissolve, helping to prevent excessive clotting. Brino capsule works by binding to plasmin and preventing its activation. This inhibits the formation of active plasmin, thereby reducing the breakdown of fibrin clots.