Amodip Tablet Uses

Amodip tablet belongs to the class of calcium channel blockers (CCB). It is primarily used to treat hypertension (high blood pressure) and certain cardiovascular conditions, including:

1. Hypertension (High Blood Pressure): Amodip tablet is commonly used as a first-line treatment for hypertension. It helps to relax and widen the blood vessels, reducing peripheral vascular resistance and lowering blood pressure. By improving blood flow, Amodip helps to reduce the workload on the heart and improve overall cardiovascular health.
2. Angina: Amodip tablet is also used to treat angina, a condition characterized by chest pain or discomfort caused by reduced blood flow to the heart muscles. By dilating the coronary arteries and improving blood supply to the heart, Amodip helps to relieve angina symptoms, such as chest pain and shortness of breath.
3. Coronary Artery Disease: Amodip tablets may be used to manage coronary artery disease, a condition where the coronary arteries that supply blood to the heart become narrowed or blocked. By improving blood flow to the heart muscles, Amodip helps to reduce symptoms and prevent complications associated with coronary artery disease.
4. Raynaud’s Phenomenon: Amodip tablet can be used to treat Raynaud’s phenomenon, a condition characterized by episodes of narrowed blood vessels in the fingers and toes, leading to coldness, numbness, and color changes. By dilating the blood vessels, Amodip helps to improve blood circulation and reduce the frequency and severity of Raynaud’s episodes.

Off-label Uses of Amodip Tablet

1. Migraine Prophylaxis: Amodip tablets may be used off-label for the prevention of migraines. It is believed that Amodip’s ability to dilate blood vessels and reduce vasospasms may help in reducing the frequency and severity of migraines in some individuals.
2. Pulmonary Arterial Hypertension (PAH): Amodip tablets may be used off-label in the treatment of pulmonary arterial hypertension, a condition characterized by high blood pressure in the arteries that supply the lungs. Amodip’s vasodilatory effects can help reduce the workload on the right side of the heart and improve symptoms in some individuals with PAH.
3. Prevention of Recurrent Miscarriages: In some cases, Amodip tablets may be used off-label as an adjunct therapy in women with a history of recurrent miscarriages. Its vasodilatory properties may help improve blood flow to the uterus and placenta, potentially reducing the risk of miscarriage.

Amodip is one of the leading brands of Amlodipine, manufactured and marketed by Mass Pharma (Pvt) Ltd, Pakistan.

The following are some alternative brands of Amodip and their manufacturers.

• Norvasc : Pfizer Laboratories Inc.
• Sofvasc : Wilsons Pharmaceuticals, Pakistan.
• Onato : Sami Pharmaceuticals (Pvt) Ltd, Pakistan.
• Ampress : Barrett Hodgson Pakistan (Pvt) Ltd.
• Hypotin : Donvalley Pharmaceuticals (Pvt) Ltd. Pakistan.
• Lodopin : Martin Dow Marker Ltd, Pakistan.
• Zodip : Zafa Pharmaceutical Laboratories (Pvt) Ltd. Pakistan.
• Coram : Brookes Pharmaceutical Laboratories Pakistan, Ltd.
• Lodopin : Martin Dow (Pvt) Ltd.
• Amdipine : Nabiqasim Industries (Pvt) Ltd. Pakistan.
• Cardiovasc : Werrick Pharmaceuticals.
• Amlod : Atco Laboratories Ltd. Pakistan.

Presently, Amodip is available in Tablet Form with the following strengths.

Amodip Tablets : 2.5mg, 5mg, and 10mg strengths.

Amodip has some contraindications, which are specific circumstances or conditions in which its use is not recommended due to potential risks or adverse effects.

• Hypersensitivity: Amodip is contraindicated in individuals who have a known hypersensitivity or allergic reaction to Amodip or any other components of the medication. Signs of a hypersensitivity reaction may include rash, itching, swelling, dizziness, or difficulty breathing.
• Severe hypotension: Amodip is contraindicated in individuals with severe hypotension (low blood pressure). It can further reduce blood pressure and lead to complications such as dizziness, fainting, or inadequate blood supply to vital organs.
• Cardiogenic shock: Amodip is contraindicated in individuals with cardiogenic shock, a condition where the heart is unable to pump enough blood to meet the body’s needs. Amodip’s vasodilatory effects can further decrease cardiac output and worsen the condition.
• Obstructive aortic stenosis: Amodip is contraindicated in individuals with significant obstruction of the outflow of blood from the heart, specifically aortic stenosis. Amodip’s vasodilatory effects can reduce blood pressure and cause a relative increase in the obstruction, potentially worsening symptoms and compromising cardiac function.

Amodip Dose for Hypertension (High Blood Pressure):

• One Tablet of 5mg, once daily.
• In some cases, higher doses may be required to achieve adequate blood pressure control.

Amodip Dose for Angina:

• One Tablet of 5mg, once daily. The dose can be increased to 10mg tablet if necessary.

Amodip Dose for Vasospastic Angina (Prinzmetal’s or Variant Angina):

• Starting Dose: One Tablet of 5mg, once daily.
• The dose may be increased to 10mg tablet if needed.
• In some cases, amlodipine can be combined with other anti-anginal medications for optimal symptom control.

Amodip works by selectively inhibiting the influx of calcium ions through the L-type calcium channels in the smooth muscle cells of the arterial walls and myocardium (heart muscle). By blocking these calcium channels, it reduces the entry of calcium into the cells, resulting in relaxation and dilation of the arterial blood vessels. This leads to a reduction in peripheral vascular resistance, allowing blood to flow more easily and lowering blood pressure.