Progyluton Side Effects

Progyluton is a combination of Estradiol Valerate and Norgestrel, typically used as a hormonal contraceptive, commonly known as a birth control pill. Progyluton provides synthetic forms of estrogen (Estradiol Valerate) and progestin (Norgestrel) to regulate the menstrual cycle and prevent pregnancy. Here are some common and less common side effects associated with Progyluton.

Common Side Effects

• Nausea: Some individuals may experience nausea, especially when they first start taking Progyluton. Taking the pill with food or before bedtime can help alleviate this side effect.
• Breast Tenderness: Changes in breast sensitivity or tenderness can occur, which is a common hormonal side effect.
• Headaches: Headaches, including migraines, can be a side effect of hormonal contraceptives.
• Breakthrough Bleeding or Spotting: Irregular bleeding between periods, especially during the first few months of use, may occur.
• Fluid Retention: Some individuals may experience mild fluid retention, leading to slight weight gain or bloating.
• Mood Changes: Hormonal contraceptives can affect mood while taking Progyluton, and some individuals may experience changes in mood, such as irritability or mood swings.
• Changes in Libido: Changes in sexual desire or libido can occur, although this effect varies among individuals.
• Weight Changes: Some individuals may experience changes in weight, either an increase or decrease while taking Progyluton.
• Skin Changes: Hormonal fluctuations can affect the skin, leading to changes such as acne or, in some cases, improved skin condition.
• Vaginal Discharge: Some individuals may notice changes in vaginal discharge.
• Menstrual Changes: While the primary purpose of Progyluton is to regulate the menstrual cycle, some women may experience changes in the frequency and intensity of their periods.
• Eye Changes: In some cases, contact lens wearers may experience changes in tolerance or fit.

Less Common Side Effects

• Changes in Libido: While a decrease in libido can be a common side effect, some individuals may experience an increase in sexual desire or changes in sexual function.
• Mood Changes: While mood swings and irritability are more common, some individuals might experience Progyluton changes in mood that are less typical, such as feelings of anxiety or depression.
• Gastrointestinal Upset: Less commonly, individuals may experience abdominal discomfort, bloating, or changes in bowel habits.
• Skin Discoloration: Rarely, Progyluton may cause darkening of the skin, especially in areas exposed to the sun or in skin creases.
• Breast Changes: Some individuals might notice changes in breast size or discomfort that are less typical than the common breast tenderness experienced with Progyluton.
• Changes in Appetite: Appetite changes, including increased or decreased appetite, are less common but can occur.
• Vaginal Discomfort: Rarely, some women may experience vaginal dryness, itching, or irritation.
• Allergic Reactions: Although uncommon, allergic reactions to components of the medication can occur, presenting as rash, itching, swelling, or difficulty breathing.
• Visual Changes: In rare instances, hormonal contraceptives may cause changes in vision or tolerance to contact lenses.
• Liver Problems: While rare, Progyluton can, in some cases, lead to liver problems such as liver tumors or jaundice.

Progyluton is one of the leading brands of Estradiol Valerate and Norgestrel, manufactured and marketed by Bayer Schering Pharma.

Presently, Progyluton is available in Tablet Form with the following strength.

Progyluton Tablet : Estradiol Valerate 2mg and Norgestrel 0.5mg strengths

1. Medications that Induce Liver Enzymes: Drugs that induce liver enzymes, such as certain anticonvulsants (e.g., phenytoin, carbamazepine), antibiotics (e.g., rifampicin), and herbal supplements (e.g., St. John’s Wort), can decrease the effectiveness of Progyluton by increasing their metabolism and reducing their blood levels.
2. Antibiotics: Some antibiotics, especially broad-spectrum antibiotics like ampicillin, tetracyclines, and some fluoroquinolones, can potentially reduce the effectiveness of Progyluton. It’s advisable to use additional contraceptive methods during antibiotic treatment and for a short period after discontinuation.
3. Antifungal Agents: Certain antifungal medications, such as griseofulvin, can decrease the effectiveness of Progyluton.
4. HIV Medications: Some medications used to treat HIV, particularly protease inhibitors and non-nucleoside reverse transcriptase inhibitors, may interact with Progyluton, affecting their effectiveness.
5. Herbal Supplements: Herbal supplements like St. John’s Wort can decrease the effectiveness of Progyluton by affecting their metabolism.
6. Seizure Medications: Certain antiepileptic drugs (AEDs), such as carbamazepine, phenytoin, phenobarbital, and primidone, can reduce the effectiveness of Progyluton.
7. Corticosteroids: Long-term use of corticosteroids might decrease the effectiveness of Progyluton.
8. Grapefruit Juice: Grapefruit juice might interfere with the metabolism of Progyluton, potentially affecting their effectiveness. It’s advisable to avoid excessive consumption while taking these medications.
9. Blood Pressure Medications: Some blood pressure medications, particularly those containing tizanidine, might interact with Progyluton.