Domel Side Effects

Domel is a medication used to treat nausea and vomiting and to help relieve symptoms of certain gastrointestinal conditions. Like all medications, it can have side effects. Here are some common and less common side effects associated with Domel.

Common Side Effects

• Headache: Headaches are a relatively common side effect when taking Domel.
• Dry Mouth: Some people may experience a dry mouth while on Domel.
• Abdominal Cramps or Discomfort: Mild abdominal discomfort may occur in some individuals when taking Domel.
• Increased Heart Rate: Domel can cause a temporary increase in heart rate in some patients.

Less Common Side Effects

• Breast Tenderness or Enlargement: Domel can increase levels of a hormone called prolactin, which may lead to breast tenderness or enlargement (gynecomastia) in some individuals, particularly men.
• Galactorrhea: Some individuals may experience the spontaneous production of breast milk (even in men) due to the increase in prolactin levels.
• Allergic Reactions: Rarely, allergic reactions such as skin rash, itching, or swelling may occur while taking Domel. In very rare cases, severe allergic reactions can occur, including anaphylaxis (a severe, life-threatening allergic reaction).
• Nervous System Side Effects: Some individuals may experience nervous system side effects associated with Domel, such as dizziness, irritability, or restlessness.
• Menstrual Irregularities: In some cases, women may experience menstrual irregularities while taking Domel.

Domel is one of the leading brands of Domperidone, manufactured and marketed by Barrett Hodgson Pakistan (Pvt) Ltd.

Presently, Domel is available in Tablet and Syrup Forms.

Domel Tablet : 10mg strength

Domel Syrup : 5ml/5ml strength

1. Antifungal Medications: Some antifungal medications, particularly those in the azole class like ketoconazole and itraconazole, can inhibit the metabolism of Domel.
2. Antibiotics: Certain antibiotics, such as erythromycin, can also interact with Domel by affecting its metabolism.
3. Other Medications Affecting Heart Rhythm: Domel can prolong the QT interval on an electrocardiogram (ECG). Combining Domel with other medications that also affect the QT interval can increase the risk of serious cardiac arrhythmias.
4. Dopamine Antagonists: Since Domel is a dopamine antagonist, its effects may be diminished when used in combination with other drugs that affect dopamine receptors. This could include antipsychotic medications and some anti-Parkinson’s drugs.
5. Grapefruit Juice: Grapefruit juice can inhibit the enzyme that metabolizes Domel, potentially leading to increased levels of the drug in the bloodstream. It’s advisable to avoid grapefruit juice while taking Domel.
6. Cimetidine: Cimetidine, an over-the-counter medication used to reduce stomach acid, may inhibit the metabolism of Domel, leading to increased levels of Drugs in the blood.
7. Other Medications: Any medication that affects liver function may potentially interact with Domel, as it is primarily metabolized by the liver. It’s important to discuss all your medications and supplements with your healthcare provider.