Distalgesic Side Effects

Distalgesic is used to manage moderate to severe pain. As with any medication, there can be side effects, both common and less common. Here are some potential side effects associated with Distalgesic.

Common Side Effects

• Nausea and Vomiting: Gastrointestinal disturbances, including nausea and vomiting, are relatively common side effects of Distalgesic.
• Dizziness:  Distalgesic can cause dizziness. It’s important to be cautious when operating machinery or engaging in activities that require focus and balance.
• Constipation: Distalgesic can slow down bowel movements, leading to constipation. This is a common side effect that may require management with dietary changes or additional medications.
• Sedation: Some individuals may experience drowsiness or sedation when taking Distalgesic.
• Dry Mouth: Dry mouth is a common side effect associated with Distalgesic.
• Headache: Headaches are among the potential side effects of Distalgesic.
• Sweating: Increased sweating, often described as “diaphoresis,” can be a side effect of Distalgesic.
• Fatigue: Some individuals may feel tired or fatigued when taking Distalgesic.

Less Common Side Effects

• Serotonin Syndrome: Distalgesic has some impact on serotonin levels in the brain, and in rare cases, it can lead to serotonin syndrome when used in combination with other medications or substances that affect serotonin, such as certain antidepressants. This condition is characterized by symptoms like agitation, hallucinations, rapid heart rate, fever, muscle stiffness, and tremors.
• Allergic Reactions: While less common, allergic reactions to Distalgesic can occur. Symptoms may include skin rashes, itching, swelling, or difficulty breathing.
• Liver Damage:  Distalgesic can be harmful to the liver, especially when taken in large doses or when combined with alcohol or other medications that affect the liver. This risk is reduced when it’s used as directed.
• Cardiovascular Effects:  Distalgesic may affect heart rate and blood pressure. While less common, some individuals may experience changes in heart rhythm or blood pressure.
• Mood Changes:  Distalgesic can impact mood, potentially leading to feelings of euphoria or, conversely, mood swings or depression.
• Dependency and Withdrawal:  Distalgesic has the potential for dependence and withdrawal symptoms if used for an extended period. These symptoms can include anxiety, agitation, insomnia, and flu-like symptoms.

Distalgesic is generically known as Tramadol + Paracetamol and it is manufactured and marketed by Atco Laboratories, Pakistan.

Presently, Distalgesic is available in Tablet Form.

Distalgesic Tablet : Tramadol 37.5mg and Paracetammol 325mg strengths

1. Alcohol: Distalgesic can be hepatotoxic, meaning it can harm the liver. Alcohol consumption while taking Distagesic can increase the risk of liver damage. It is generally advised to avoid or limit alcohol when using the medications.
2. Other Opioid Medications: Combining Distalgesic with other opioids, such as codeine, morphine, or hydrocodone, can increase the risk of opioid-related side effects, including respiratory depression, sedation, and overdose. Distalgesic should only be done under close medical supervision.
3. Sedative Medications: Combining Distalgesic with other sedative medications, such as benzodiazepines or certain sleep aids, can increase the risk of central nervous system depression, including drowsiness, slowed breathing, and impaired cognitive function.
4. Serotonergic Medications: Distalgesic has some impact on serotonin levels in the brain. Combining it with other medications that affect serotonin, such as selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), or certain migraine medications, can increase the risk of serotonin syndrome. Serotonin syndrome is a potentially life-threatening condition characterized by symptoms like agitation, hallucinations, rapid heart rate, fever, muscle stiffness, and tremors.
5. Monoamine Oxidase Inhibitors (MAOIs): Combining Distalgesic with MAOIs, a class of antidepressants, can lead to serious and potentially life-threatening interactions. MAOIs can increase the risk of serotonin syndrome, seizures, and severe hypertension (elevated blood pressure).
6. Anticoagulants: Distalgesic may interact with anticoagulant medications, like warfarin, potentially increasing the risk of bleeding. If you are taking an anticoagulant, consult your healthcare provider before using this combination.
7. Anticholinergic Medications: Some medications with anticholinergic effects (e.g., certain antihistamines, tricyclic antidepressants) can enhance the side effects of Distalgesic, such as dry mouth, constipation, and urinary retention.
8. Medications Affecting Liver Function: The active ingredients of Distalgesic are metabolized in the liver, medications that affect liver function, such as certain antibiotics or antifungal drugs, may influence the metabolism of these drugs and potentially lead to changes in their blood levels.