Augmentin Side Effects

Augmentin is a combination antibiotic that is used to treat a variety of bacterial infections. Like any medication, Augmentin can cause side effects. Common and less common side effects of Augmentin.

Common Side Effects

• Gastrointestinal Upset: This is one of the most common side effects associated with Augmentin and may include diarrhea, nausea, vomiting, and abdominal pain.
• Skin Rash: Some people may develop a mild rash while taking Augmentin.
• Allergic Reactions: Allergic reactions can occur, leading to symptoms such as hives, itching, swelling, difficulty breathing, or severe skin reactions.
• Thrush (Oral or Vaginal Yeast Infection): Augmentin can disrupt the balance of normal flora in the body, potentially leading to yeast infections in the mouth or genitals.

Less Common Side Effects

• Liver Problems: In rare cases, Augmentin can lead to liver damage, which may result in symptoms like jaundice (yellowing of the skin and eyes), dark urine, and abdominal pain.
• Blood Disorders: Augmentin may rarely affect blood cell counts, leading to conditions such as anemia, leukopenia (low white blood cell count), or thrombocytopenia (low platelet count).
• Kidney Problems: Augmentin can cause kidney problems, which may manifest as changes in urine output or color, as well as swelling in the legs and ankles.
• Nervous System Effects: Some individuals may experience nervous system side effects with Augmentin like dizziness, confusion, or seizures, though these are relatively rare.

Augmentin is one of the leading brands of Co-Amoxiclav, manufactured and marketed by GlaxoSmithKline.

Presently, Augmentin is available in Tablet, Injection, Drops, and Syrup Forms.

Augmentin Tablets : 375mg, 625mg, and 1g strengths

Augmentin Syrup : 156.25mg, 312.5mg, and 457mg/5ml strengths

Augmentin Injection : 1.2g and 600mg strengths

Augmentin Drops : 62.5mg strength

1. Allopurinol: Augmentin may increase the risk of skin rashes when used with allopurinol, a medication commonly used for gout and kidney stones.
2. Methotrexate: Augmentin may increase the blood levels of methotrexate, which is used to treat conditions like rheumatoid arthritis, psoriasis, and certain types of cancer. This can lead to an increased risk of methotrexate-related side effects.
3. Probenecid: Probenecid is sometimes used in combination with antibiotics to enhance their effectiveness. When combined with Augmentin, it can increase the blood levels of amoxicillin, which may be beneficial in some cases but can also lead to an increased risk of side effects.
4. Warfarin: Augmentin may alter the effects of warfarin, a blood thinner. It’s important to monitor the blood clotting time (INR) when these two medications are used together, as adjustments to the warfarin dosage may be necessary.
5. Oral Contraceptives: There is a theoretical risk that Augmentin may reduce the effectiveness of oral contraceptives. It is recommended to use additional contraceptive methods while taking Augmentin to prevent unintended pregnancies.
6. Methotrexate and Other Immunosuppressive Drugs: Augmentin may increase the risk of infections when used in combination with immunosuppressive medications, such as methotrexate, cyclosporine, or mycophenolate mofetil.
7. Probiotics: Some people take probiotics to maintain gut health. Augmentin may affect the balance of gut bacteria, and using probiotics may help mitigate gastrointestinal side effects.
8. Antacids and Acid Reducers: The absorption of Augmentin can be reduced by antacids containing aluminum or magnesium or by acid-reducing medications like proton pump inhibitors (PPIs) and H2 blockers. To avoid interactions, it’s generally recommended to take Augmentin at least 2 hours before or after these products.
9. Live Bacterial Vaccines: Augmentin may interfere with the effectiveness of live bacterial vaccines. You should discuss your vaccination schedule with your healthcare provider while taking this medication.
10. Other Antibiotics: Augmentin should not be used concurrently with other antibiotics, especially those with a similar spectrum of activity, without careful consideration by a healthcare professional.