Zyloric Side Effects

Zyloric is a medication commonly used to treat gout and prevent the formation of uric acid crystals in the body. While it is generally considered safe and effective, like all medications, it can have side effects. Common and less common side effects of Zyloric include:

Common Side Effects

• Skin Rash: This is one of the most common side effects of Zyloric. It can range from mild to severe, and in some cases, it can be a sign of a more serious allergic reaction.
• Gastrointestinal Disturbances: Nausea, vomiting, and diarrhea can occur in some individuals when taking Zyloric.
• Elevated Liver Enzymes: Zyloric can sometimes lead to abnormal liver function tests, which may necessitate monitoring by your healthcare provider.

Less Common Side Effects

• Allergic Reactions: Although less common, Zyloric can cause serious allergic reactions, including severe skin rashes, fever, and organ damage. If you experience any signs of an allergic reaction, such as difficulty breathing, swelling, or a severe rash, seek immediate medical attention.
• Blood Disorders: Zyloric may cause changes in blood cell counts, such as a decrease in white blood cells (leukopenia), red blood cells (anemia), or platelets (thrombocytopenia). These can potentially lead to complications like infections or bleeding.
• Kidney Problems: Zyloric can cause kidney problems or exacerbate existing kidney issues. Regular kidney function monitoring may be required while taking this medication.
• Hypersensitivity Syndrome: A potentially serious, systemic allergic reaction that can affect multiple organ systems, including the liver, kidneys, and blood cells.

Zyloric is one of the leading brands of Allopurinol, manufactured and marketed by GlaxoSmithKline.

Presently, Zyloric is available in Tablet Form.

Zyloric Tablets : 100mg and 300mg Strengths

1. Azathioprine and Mercaptopurine: Zyloric can interact with these medications, which are used to suppress the immune system, often for conditions like inflammatory bowel disease or after organ transplantation. The combination can lead to an increased risk of bone marrow suppression and adverse effects on blood cells.
2. Warfarin: Zyloric may affect the metabolism of warfarin (a blood thinner) potentially leading to changes in its anticoagulant effect. Regular monitoring of the International Normalized Ratio (INR) is advisable when using these drugs together.
3. Theophylline: Zyloric may increase the levels of theophylline in the blood, which can lead to an increased risk of theophylline toxicity. Dose adjustments may be necessary if both medications are prescribed.
4. Ampicillin/Amoxicillin: When Zyloric is taken with ampicillin or amoxicillin, it may increase the risk of skin rashes, especially in patients with a history of ampicillin or amoxicillin hypersensitivity.
5. Diuretics (e.g., thiazides): Concurrent use of diuretics with Zyloric can affect the excretion of uric acid, potentially altering the effectiveness of Zyloric. Your healthcare provider may need to adjust your dosage or closely monitor your response to treatment.
6. ACE Inhibitors and Angiotensin Receptor Blockers (ARBs): There have been reports of Zyloric increasing the risk of hypersensitivity reactions in patients taking ACE inhibitors or ARBs, commonly used for high blood pressure and heart conditions.
7. Cytotoxic Chemotherapy: Zyloric can interact with certain chemotherapy drugs, potentially leading to increased toxicity. Patients receiving chemotherapy should be closely monitored if Zyloric is prescribed.
8. Probenecid: Probenecid is another medication used to manage gout by increasing uric acid excretion. The combination of Zyloric and probenecid is sometimes used, but it may require dosage adjustments to prevent excessive lowering of uric acid levels.
9. Iron Supplements: Zyloric can interfere with the absorption of iron supplements. To ensure you get the full benefit of iron supplementation, it’s recommended to take iron supplements separately from Zyloric.