Synalgo Side Effects

Synalgo is a nonsteroidal anti-inflammatory drug (NSAID) that is used to reduce pain and inflammation. Like all medications, Synalgo has side effects, both common and less common.

Common Side Effects

• Gastrointestinal Issues: Synalgo irritates the stomach lining, leading to common side effects such as stomach pain, heartburn, indigestion, nausea, and diarrhea.
• Headache: Some individuals may experience headaches while taking Synalgo.
• Dizziness: Dizziness is a relatively common side effect of Synalgo, which may affect some people.
• Fluid Retention: Swelling, edema, and fluid retention are known side effects of Synalgo, particularly in the legs and ankles.
• Skin Rash: Skin reactions such as rashes, itching, or hives can occur with Synalgo.
• High Blood Pressure: Synalgo can raise blood pressure in some individuals, so regular monitoring is essential for those at risk.

Less Common Side Effects

• Gastrointestinal Ulcers and Bleeding: While less common, Synalgo can cause gastrointestinal ulcers and bleeding, which can be serious and even life-threatening. Symptoms include black, tarry stools, or vomiting blood.
• Kidney Issues: Synalgo can lead to kidney problems, including reduced kidney function, kidney inflammation, and increased risk of kidney stones. Symptoms may include changes in urination and flank pain.
• Liver Dysfunction: In rare cases, liver abnormalities and elevated liver enzymes have been reported as side effects of Synalgo.
• Cardiovascular Events: There is a potential for an increased risk of cardiovascular events, such as heart attack or stroke, particularly with long-term and high-dose Synalgo. Individuals with cardiovascular risk factors should be cautious.
• Allergic Reactions: Though rare, some people may experience severe allergic reactions to Synalgo, leading to symptoms like difficulty breathing, swelling of the face or throat, and rash.
• Asthma Exacerbation: Synalgo may worsen asthma symptoms in some individuals or trigger asthma attacks.
• Gastrointestinal Perforation: Extremely rare but very serious, gastrointestinal perforation (the development of a hole in the digestive tract) can occur with Synalgo.
• Central Nervous System Effects: Some people may experience central nervous system effects, such as confusion or hallucinations, although these are less common side effects of Synalgo.

Synalgo is one of the leading brands of Flurbiprofen, manufactured and marketed by Platinum Pharmaceuticals (Pvt) Ltd.

Presently, Synalgo is available in Tablet Form

Synalgo Tablet : 100mg Strength

1. Other NSAIDs: Concurrent use of multiple NSAIDs, including Synalgo, can increase the risk of gastrointestinal ulcers, bleeding, and other side effects. It is generally not advisable to take multiple NSAIDs simultaneously.
2. Aspirin: Combining Synalgo with aspirin can increase the risk of gastrointestinal bleeding and ulceration. Additionally, using aspirin with Synalgo may diminish the anti-inflammatory effects of the latter.
3. Anticoagulants (Blood Thinners): Synalgo may enhance the effects of anticoagulant medications, such as warfarin or heparin, increasing the risk of bleeding. Regular monitoring of blood clotting parameters is essential when using these medications together.
4. Antiplatelet Drugs: Similar to anticoagulants, combining Synalgo with antiplatelet medications like clopidogrel can increase the risk of bleeding.
5. Selective Serotonin Reuptake Inhibitors (SSRIs) and Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs): Synalgo can increase the risk of gastrointestinal bleeding when used in combination with SSRIs or SNRIs, which are commonly used to treat depression and anxiety.
6. Corticosteroids: Using Synalgo with corticosteroids can increase the risk of gastrointestinal bleeding and ulceration. These drugs should be used together cautiously and under close medical supervision.
7. Methotrexate: Synalgo may interfere with the elimination of methotrexate, potentially increasing its toxicity. It is advisable to avoid or closely monitor this combination.
8. ACE Inhibitors: Synalgo can reduce the blood pressure-lowering effects of angiotensin-converting enzyme (ACE) inhibitors like enalapril or lisinopril. Blood pressure should be closely monitored when using these medications together.
9. Lithium: Synalgo may increase lithium levels in the blood, potentially leading to lithium toxicity. Regular monitoring of lithium levels is essential if these medications are combined.
10. Diuretics: Diuretics, especially thiazide diuretics, can reduce the effectiveness of Synalgo and increase the risk of kidney problems. Close monitoring and dosage adjustments may be necessary.
11. Angiotensin II Receptor Blockers (ARBs): Synalgo can reduce the effectiveness of ARBs like losartan and valsartan in lowering blood pressure. Regular blood pressure monitoring is important in this case.
12. Beta-Blockers: Combining Synalgo with beta-blockers can potentially reduce the antihypertensive effects of the latter.