Coldrex Side Effects

Coldrex is an over-the-counter medication used to relieve symptoms associated with colds and allergies. Like any medication, Coldrex can have side effects, which can vary from common and mild to less common and more severe.

Common Side Effects

• Drowsiness: In Coldrex Chlorpheniramine, an antihistamine, can cause drowsiness or sedation, which is a common side effect. Dextromethorphan, although not as sedating as some other cough suppressants, may also contribute to drowsiness in some individuals.
• Dry Mouth and Throat: Dry mouth and throat are common side effects of Coldrex, which has anticholinergic properties.
• Nausea: Some individuals may experience mild nausea when taking Coldrex, particularly if taken on an empty stomach.

Less Common Side Effects

• Nervousness or Excitability: In some cases, Coldrex can cause nervousness or excitability, especially in children.
• Dizziness: Dizziness may occur, especially when getting up from a sitting or lying position, as a result of the blood pressure-lowering effect of Coldrex.
• Stomach Upset or Heartburn: Less commonly, individuals may experience stomach upset or heartburn.
• Blurred Vision: Some people may experience blurred vision while taking Coldrex.
• Difficulty Urinating: Coldrex may cause difficulty in urination, especially in men with prostate enlargement.
• Allergic Reactions: Although rare, severe allergic reactions can occur, characterized by symptoms such as swelling of the face, lips, tongue, or throat, difficulty breathing, and hives.
• Serious Liver Problems: Coldrex, when taken in excessive doses or over an extended period, can lead to liver damage. It’s crucial to adhere to recommended dosages and guidelines.
• Overdose: An overdose of Coldrex can be life-threatening and may lead to liver damage. It is important to follow dosing instructions carefully and avoid taking other medications containing Coldrex at the same time.

Coldrex is one of the leading brands with a combination of Paracetamol, Dextromethorphan, and Chlorpheniramine, manufactured and marketed by Standpharm Pakistan (Pvt) Ltd.

Presently, Coldrex is available in Tablet and Syrup Forms

Coldrex Tablet : Paracetamol 325mg, Dextromethorphan 10mg, and Chlorpheniramine 1mg strengths

Coldrex Syrup : Paracetamol 325mg/5ml, Dextromethorphan 15mg/5ml, and Chlorpheniramine 1mg/5ml strengths

1. Sedative Medications: Coldrex the combination of Dextromethorphan and Chlorpheniramine can have sedative effects. Therefore, taking other medications with sedative properties, such as benzodiazepines, certain sleep aids, or muscle relaxants, can enhance the sedation and cause drowsiness or impairment. It’s advisable to avoid the concurrent use of Coldrex, especially when driving or operating heavy machinery.
2. Monoamine Oxidase Inhibitors (MAOIs): Combining Coldrex with MAOIs, a class of antidepressants, can lead to serious, potentially life-threatening reactions, including hypertensive crises. MAOIs are typically avoided with drugs containing Chlorpheniramine and Dextromethorphan.
3. Alcohol: Alcohol can enhance the sedative effects of Coldrex, leading to excessive drowsiness or impairment. It’s best to avoid alcohol while using Coldrex.
4. Other Cold and Cough Medications: Using multiple over-the-counter cold and cough medications at the same time can result in the ingestion of excessive amounts of specific active ingredients, such as Paracetamol, which can lead to overdose. Be cautious and avoid taking other cold and cough medications without consulting a healthcare provider.
5. Anticholinergic Medications: Combining Coldrex with other anticholinergic drugs, such as certain medications for allergies, motion sickness, or irritable bowel syndrome, can increase the risk of anticholinergic side effects like dry mouth, constipation, and urinary retention.
6. Antidepressants: Some antidepressants, particularly tricyclic antidepressants, can interact with Coldrex, potentially leading to increased sedation and other side effects. Discuss the use of this combination medication with your healthcare provider if you are taking antidepressants.
7. Drugs That Affect Liver Function: Since Coldrex is metabolized in the liver, taking Coldrex with other medications that affect liver function can increase the risk of liver damage. These drugs may include antifungal medications, certain anticonvulsants, and others. Consult your healthcare provider if you are using any medications that affect the liver.