Tonoflex P Side Effects

Tonoflex P is the combination of Tramadol hydrochloride (HCl) and Paracetamol is often prescribed for moderate to severe pain relief. Tonoflex P can be effective for managing pain, but it can also have side effects. It’s important to take this medication exactly as prescribed by your healthcare provider and to be aware of potential side effects.

Common Side Effects of Tonoflex P

1. Nausea: Nausea is a common side effect of Tonoflex P. Taking the medication with food or milk may help reduce nausea.
2. Dizziness: Tonoflex P can cause dizziness or lightheadedness, which can increase the risk of falls or accidents. Avoid activities that require mental alertness, such as driving or operating heavy machinery, until you know how the medication affects you.
3. Drowsiness: Tonoflex P can also cause drowsiness in some people. It’s important not to consume alcohol or use other medications that can increase drowsiness when taking Tonoflex P.
4. Constipation: Opioid medications like Tonoflex P can lead to constipation. Drinking plenty of water, eating a high-fiber diet, and staying active can help alleviate this side effect.
5. Headache: Some people may experience headaches as a side effect of Tonoflex P.
6. Dry mouth: Dry mouth can occur with the use of Tonoflex P.
7. Sweating: Excessive sweating or perspiration may occur with Tonoflex P use.
8. Itching or Rash: Skin itching or rashes may occur in some individuals.
9. Digestive Issues: Tonoflex P can occasionally cause stomach discomfort or upset.
10. Liver Effects: Tonoflex P is metabolized by the liver, and in rare cases, high doses or long-term use can lead to liver problems.

Tonoflex P is one of the leading brands of Tramadol HCl and Paracetamol, manufactured and marketed by Sami Pharmaceuticals (Pvt) Ltd Pakistan.

Presently, Tonoflex P is available in Tablet and Capsule Form with the following strengths.

Tonoflex P Tablet : Each Tablet contains Paracetamol 325mg and Tramadol HCl 37.5mg strengths

1. Other Opioid Medications: Taking Tonoflex P with other opioid medications (e.g., codeine, morphine, oxycodone) can increase the risk of respiratory depression, sedation, and overdose. Tonoflex P should be used with caution and only under the strict supervision of a healthcare provider.
2. Sedatives or CNS Depressants: Combining Tonoflex P with other central nervous system (CNS) depressants, such as benzodiazepines (e.g., diazepam), muscle relaxants, or alcohol, can lead to increased drowsiness, sedation, and respiratory depression. Avoid using Tonoflex P concurrently unless directed by a healthcare provider.
3. Serotoninergic Medications: Tonoflex P has some serotoninergic activity and can interact with other medications that affect serotonin levels, such as selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs). Tonoflex P may increase the risk of serotonin syndrome, a potentially life-threatening condition characterized by symptoms like agitation, confusion, rapid heart rate, and high blood pressure.
4. Monoamine Oxidase Inhibitors (MAOIs): Combining Tonoflex P with MAOIs can also increase the risk of serotonin syndrome. MAOIs are a type of antidepressant.
5. Warfarin and Blood Thinners: Tonoflex P can increase the risk of bleeding when taken with blood-thinning medications like warfarin. Monitoring of blood clotting times may be necessary.
6. Antidepressants: Some tricyclic antidepressants may interact with Tonoflex P, potentially increasing the risk of seizures or serotonin syndrome.
7. Antiepileptic Medications: Tonoflex P may lower the seizure threshold, potentially interacting with certain antiepileptic medications and increasing the risk of seizures.
8. Rifampin: Rifampin, an antibiotic, may decrease the effectiveness of Tonoflex P by increasing its metabolism and reducing its pain-relieving effects.
9. Certain Antifungal Medications: Some antifungal medications (e.g., ketoconazole) may interact with Tonoflex P, potentially affecting its metabolism and leading to increased side effects.