Inosita Tablet Uses

Inosita is a medication primarily used to treat type 2 diabetes. It belongs to a class of drugs called dipeptidyl peptidase-4 (DPP-4) inhibitors. The following are some common uses and indications of Inosita Tablet:

1. Type 2 Diabetes: Inosita tablet is used in people with type 2 diabetes to help control their blood sugar levels. It is often used in combination with other medications such as metformin or sulfonylureas when lifestyle changes alone are not sufficient to manage blood glucose levels.
2. Blood Sugar Control: The use of Inosita tablets helps lower fasting and post-meal blood sugar levels, making it an effective treatment option for individuals with type 2 diabetes.
3. Monotherapy or Combination Therapy: Inosita tablet can be used alone (monotherapy) or in combination with other diabetes medications, such as metformin, sulfonylureas, or insulin, to achieve better blood sugar control.
4. Adjunctive Therapy: Inosita tablet is also used in combination with other diabetes medications, such as metformin, sulfonylureas, or insulin when these medications alone are not effectively controlling blood sugar levels.
5. Long-Term Treatment: It is suitable for long-term use in individuals with type 2 diabetes to help maintain stable blood sugar levels.
6. Maintaining A1C Levels: Using Inosita tablets can help lower hemoglobin A1C levels, which is a measure of average blood sugar levels over the past two to three months. Lower A1C levels are associated with a reduced risk of diabetes-related complications.

Off-label Uses of Inosita Tablet

1. Polycystic Ovary Syndrome (PCOS): Some healthcare providers may consider using Inosita tablets in women with PCOS who have insulin resistance and abnormal glucose metabolism. It can help improve insulin sensitivity and regulate menstrual cycles.
2. Prediabetes: Inosita tablet may be used off-label in individuals with prediabetes (higher-than-normal blood sugar levels but not yet meeting the criteria for type 2 diabetes) to help prevent the progression to full-blown diabetes.
3. Gestational Diabetes: In some cases, Inosita tablets may be considered for pregnant women with gestational diabetes when other treatments are not effective or suitable. However, the safety of Inosita tablets during pregnancy is still being studied.
4. Non-Alcoholic Fatty Liver Disease (NAFLD): Inosita tablet may have a beneficial effect on liver health in individuals with NAFLD, as it can help improve insulin sensitivity and reduce liver inflammation.
5. Weight Loss: While not a primary indication, some studies have explored the potential for Inosita tablets to aid in weight loss, particularly in individuals with obesity and diabetes. However, its weight-loss effects are generally modest.

Benefits of Using Inosita Tablet

• Blood Sugar Stability: Inosita tablet can help stabilize blood sugar levels, reducing the likelihood of hypoglycemia (low blood sugar) when used appropriately.
• Preventing Complications: By controlling blood sugar levels, Inosita tablets can help reduce the risk of diabetes-related complications, such as kidney problems, nerve damage, vision problems, and heart disease.
• May Have Cardiovascular Benefits: Some studies suggest that Inosita tablets, along with other DPP-4 inhibitors, may have cardiovascular benefits, although more research is needed to fully understand this potential benefit.

Inosita is one of the leading brands of Sitagliptin, manufactured and marketed by Pharmevo Pakistan (Pvt) Ltd.

The following are some alternative brands of Inosita and their manufacturers.

• Sitaglu : Hilton Pharmaceuticals (Pvt) Ltd, Pakistan.
• Giva : Genix Pharmaceuticals (Pvt) Ltd, Pakistan.
• Sitagen : Ferozsons Laboratories Ltd, Pakistan.
• Tagip : Highnoon Laboratories Ltd, Pakistan.
• Trevia : Getz Pharma Pakistan (Pvt) Ltd.
• Gliptin : Himont Pharmaceuticals (Pvt) Ltd, Pakistan.
• Sita : CCL (Consolidated Chemical Laboratories (Pvt) Ltd)
• Bounty : Wilsons Pharmaceuticals, Pakistan.
• Nuvia : Werrick Pharmaceuticals, Pakistan.
• Januvia : OBS Pharma, Pakistan.

Presently, Inosita is available in Tablet form.

• Inosita Tablet : 25mg, 50mg, and 100mg strengths.

Inosita tablets have certain contraindications, which means there are situations or conditions in which the use of this medication is not recommended.

• Hypersensitivity or Allergy: Individuals who have had a hypersensitivity reaction or allergy to Sitagliptin or any of the other components in the formulation should not take this medication.
• Type 1 Diabetes: Inosita tablet is specifically indicated for type 2 diabetes. It is not intended for use in type 1 diabetes, where the body does not produce any insulin.
• Diabetic Ketoacidosis (DKA): Inosita tablet is not suitable for treating diabetic ketoacidosis, a severe complication of diabetes characterized by high blood sugar levels, ketones in the blood, and acidosis.
• Severe Renal Impairment: For individuals with severe renal impairment (creatinine clearance less than 30 mL/min), dosage adjustments or alternative treatments may be necessary. In some cases, Inosita tablet may not be recommended.
• End-Stage Renal Disease (ESRD): Inosita tablet is generally not recommended for individuals with end-stage renal disease, particularly if they are on dialysis.
• Pancreatitis: Inosita tablet should be used with caution in individuals with a history of pancreatitis, as it may exacerbate the condition.
• Pregnancy and Breastfeeding: While there isn’t enough data to determine the safety of Inosita tablets in pregnancy and breastfeeding, it is typically recommended to use other options in these cases.
• Children: The safety and effectiveness of Inosita tablets in children under 18 years of age have not been established.
• Liver Disease: While Inosita tablet is primarily excreted by the kidneys, it’s advised to exercise caution in individuals with severe hepatic (liver) impairment.
• Alcohol Abuse: Inosita tablets may have interactions with alcohol. It’s important for individuals with a history of alcohol abuse to discuss this with their healthcare provider.

Inosita Tablet Dose for Adults with Type 2 Diabetes:

• One Tablet of 100 mg, taken orally once daily.
• It can be taken with or without food.
• If a lower initial dose is required due to certain factors (e.g., renal impairment), the dose may be reduced to 50 mg once daily.

Inosita Tablet Dose for Individuals with Renal Impairment:

In cases of moderate renal impairment (creatinine clearance between 30 to 50 mL/min):

• One tablet of 50 mg once daily.

In cases of severe renal impairment (creatinine clearance less than 30 mL/min) or end-stage renal disease (ESRD) requiring dialysis:

• The dose may be adjusted based on the specific situation.

Inosita Tablet Dose for Polycystic Ovary Syndrome (PCOS):

• One tablet of 100 mg once daily.

Inosita Tablet Dose for Heart Failure:

• One tablet of 50 mg once daily.

Inosita works by increasing the levels of certain natural substances called incretins in the body. Incretins help to regulate blood sugar levels by stimulating the release of insulin and reducing the amount of glucose produced by the liver after meals.