Azotek Tablet Uses

Azotek tablet is an antibiotic that belongs to a class of drugs known as macrolides used to treat a variety of bacterial infections. The following are some common uses and indications of Azotek Tablet:

1. Respiratory Tract Infections:
   • Pneumonia: Azotek tablet is often used to treat bacterial pneumonia, which is an infection in the lungs.
   • Bronchitis: Azotek may be prescribed for acute bacterial bronchitis, especially if caused by susceptible organisms.
   • Sinusitis: Using Azotek tablets can be effective in treating bacterial sinus infections.
2. Skin and Soft Tissue Infections:
   • Cellulitis: Azotek tablet may be used for certain cases of bacterial skin infections.
   • Impetigo: It can be prescribed for this highly contagious skin condition caused by specific bacteria.
3. Sexually Transmitted Infections (STIs):
   • Chlamydia: Azotek is one of the recommended treatments for chlamydia, a common sexually transmitted infection.
   • Gonorrhea: It may be used in combination with another antibiotic to treat gonorrhea.
4. Ear Infections:
   • Otitis Media: Azotek tablet is sometimes used to treat middle ear infections in children or adults.
5. Throat Infections:
   • Tonsillitis: Azotek tablets can be used for bacterial tonsillitis.
6. Traveler’s Diarrhea: Azotek tablets may be used for treating traveler’s diarrhea caused by specific bacteria.
7. Stomach Ulcers Associated with Helicobacter pylori:
   • In combination with other medications, Azotek tablets may be used to treat stomach ulcers caused by this bacterium.
8. Preventing Bacterial Infections in Certain Medical Procedures:
   • In specific cases, Azotek tablets might be used to prevent bacterial infections before dental or surgical procedures.
9. MAC (Mycobacterium avium complex) Infections:
   • Azotek tablet is used in combination with other medications to treat infections caused by MAC, which can occur in people with weakened immune systems.

Off-label Uses of Azotek Tablet

1. COVID-19:
   • During the COVID-19 pandemic, Azotek was trialed for its potential antiviral and anti-inflammatory effects. However, its use in COVID-19 treatment is a subject of ongoing research and should be administered under strict medical supervision.
2. Chronic Obstructive Pulmonary Disease (COPD):
   • Azotek tablet has been used off-label to reduce exacerbations and improve lung function in patients with severe COPD.
3. Cystic Fibrosis:
   • In individuals with cystic fibrosis, Azotek may be used to reduce inflammation, improve lung function, and reduce the frequency of exacerbations.
4. Bronchiolitis Obliterans Syndrome (BOS):
   • Azotek has been used in lung transplant recipients to potentially reduce the risk of bronchiolitis obliterans syndrome, a type of chronic rejection.
5. Interstitial Lung Disease (ILD):
   • The use of Azotek in patients with certain forms of interstitial lung disease potentially improves symptoms and slows disease progression.
6. Preventing Respiratory Infections in HIV/AIDS Patients:
   • Azotek tablets may be used as prophylaxis to prevent certain bacterial infections in individuals with advanced HIV/AIDS.
7. Mycoplasma pneumoniae Infections:
   • Azotek may be used off-label to treat infections caused by Mycoplasma pneumoniae, a type of bacteria.
8. Rhinovirus Infections:
   • Azotek tablets are used in combination with other medications for the treatment of respiratory infections caused by rhinoviruses.
9. Prophylaxis for Surgical Site Infections:
   • In certain surgical procedures, especially orthopedic surgeries, Azotek may be used as part of a prophylactic antibiotic regimen to prevent post-operative infections.
10. Gastrointestinal Disorders:
    • Inflammatory Bowel Disease (IBD): Azotek may be used to reduce inflammation in some cases of IBD.
    • Functional Dyspepsia: Azotek tablet is used off-label to treat functional dyspepsia, a condition characterized by chronic stomach pain or discomfort.
    • Gastroparesis: In some cases, Azotek may be used to help manage symptoms of gastroparesis, a condition where the stomach takes longer to empty its contents.
11. Acne: Azotek tablet’s anti-inflammatory properties may be beneficial in treating certain types of acne, particularly those caused or exacerbated by bacteria.

Azotek is one of the leading brands of Azithromycin, manufactured and marketed by Saffron Pharmaceuticals (Pvt) Ltd.

The following are some alternative brands of Azotek and their manufacturers.

• Azitma : Sami Pharmaceuticals, Pakistan.
• Azomax : Novartis, Pakistan.
• Macrobac : Asian Continental Pharmaceuticals, Pakistan.
• Zyto : High-Q Pharmaceuticals (Pvt) Ltd, Pakistan.
• Zetro : Getz Pharmaceuticals (Pvt) Ltd, Pakistan.
• Zezot : Bosch Pharmaceuticals, Pakistan.
• Zithromax : Pfizer Pharmaceuticals.
• Atizor : Macter International.
• Exthro : Indus Pharmaceuticals, Pakistan.
• Azitral : Nova Med Pharmaceuticals, Pakistan.
• Rescue : Standpharm Pakistan (Pvt) Ltd.

Presently, Azotek is available in Tablet form.

• Azotek Tablet : 250mg and 500mg strengths

Azotek tablets have certain contraindications, which are conditions or situations where the use of the medication is not recommended due to potential risks.

• Allergy or Hypersensitivity to Azotek: Individuals who have had an allergic reaction to azithromycin or any macrolide antibiotics (e.g., erythromycin, clarithromycin) should not use Azotek tablets.
• Allergic Reactions to Other Macrolides or Ketolides: People who have experienced severe allergic reactions (e.g., difficulty breathing, hives, swelling of the face, lips, tongue, or throat) to other macrolides or ketolides should avoid Azotek.
• Hypersensitivity to Any Component of the Formulation: This includes allergies to inactive ingredients in the tablet.
• Jaundice or Liver Dysfunction Associated with Prior Azotek Use: If a patient has a history of jaundice (yellowing of the skin or eyes) or liver dysfunction due to previous Azotek use, it may be contraindicated.
• Severe Kidney Disease: Azotek is primarily excreted by the liver and eliminated in bile. It may accumulate in patients with severe kidney impairment.
• Myasthenia Gravis: Azotek may exacerbate the symptoms of myasthenia gravis, a neuromuscular disorder.
• Long QT Syndrome and QT Prolongation: Azotek has been associated with prolongation of the QT interval on the electrocardiogram. It should be used with caution or avoided in individuals with a history of this condition.
• Arrhythmias: Azotek may increase the risk of certain heart rhythm disturbances. It should be used with caution in individuals with a history of arrhythmias.
• Pregnancy and Breastfeeding:
  1. Pregnancy: The safety of Azotek in pregnancy has not been established conclusively. It should be used during pregnancy only if the potential benefits outweigh the potential risks.
  2. Breastfeeding: Azotek may be excreted in breast milk. It should be used with caution in breastfeeding women, and the potential benefits should be weighed against potential risks.
• Children (for certain formulations): Some formulations of Azotek are not suitable for young children, so specific pediatric formulations should be used.

Azotek Tablet Dose for Respiratory Tract Infections:

• For Adults: One tablet of 500mg once daily for 3 days (or a longer course depending on the specific infection).
• For Children: The dose is based on weight and will be determined by your healthcare provider.

Azotek Tablet Dose for Sexually Transmitted Infections (Chlamydia):

• The standard dose for treating chlamydia is a single 1-gram (Two Tablets of 500 mg) dose.
• Some providers may recommend a 500 mg dose on day 1, followed by one tablet of 250 mg once daily for the next 3 days.

Azotek Tablet Dose for Skin and Soft Tissue Infections:

• One tablet of 500 mg once daily for 3 days.

Azotek Tablet Dose for Strep Throat (Streptococcal Pharyngitis):

• One tablet of 500 mg once daily for 3 days.

Azotek Tablet Dose for Ear Infections:

One tablet 500 mg once daily for 1 to 3 days.

Azotek Tablet Dose for Preventing MAC (Mycobacterium avium complex) Infections in HIV/AIDS:

• The typical dose for preventing MAC infections is 1200 mg once weekly.

Azotek Tablet Dose for Traveler’s Diarrhea:

• Two tablets of 500mg (1000 mg) as a single dose.

Azotek Tablet Dose for Pneumonia:

• The dose for pneumonia can vary depending on the specific type of pneumonia and its severity. It’s usually determined by the treating healthcare provider.

Azotek works by inhibiting bacterial protein synthesis, which is crucial for the growth and survival of bacteria. Azotek binds to the 50S subunit of the bacterial ribosome, which is a cellular structure responsible for assembling proteins. This binding interferes with the ability of the ribosome to synthesize proteins.