Cebosh Syrup Uses

Cebosh syrup is an antibiotic medication that is used primarily to treat a wide variety of bacterial infections in babies and children. Cebosh syrup is typically prescribed for pediatric patients or individuals who have difficulty swallowing tablets or capsules. The following are some common uses and indications of Cebosh Syrup:

1. Otitis Media (Middle Ear Infection): Cebosh can be prescribed to treat bacterial infections of the middle ear, which often occur in children. It helps alleviate symptoms and clear the infection.
2. Pharyngitis and Tonsillitis: Cebosh syrup can be used to treat bacterial throat infections, such as streptococcal pharyngitis (strep throat) and tonsillitis, in children.
3. Sinusitis: Cebosh may be prescribed for bacterial sinus infections in children when warranted by the healthcare provider.
4. Community-Acquired Pneumonia: This antibiotic can be used to treat bacterial pneumonia acquired outside of a hospital or healthcare setting.
5. Urinary Tract Infections: Cebosh can be effective in treating urinary tract infections (UTIs) in children, particularly those caused by susceptible bacteria.
6. Skin and Soft Tissue Infections: It might be used for certain skin and soft tissue infections in children, especially when caused by susceptible bacteria.

Off-label Uses of Cebosh Syrup

1. Prophylaxis: Cebosh might be used off-label as prophylaxis (preventive treatment) for certain bacterial infections, especially in cases where a person is at high risk of developing an infection due to medical conditions or surgical procedures.
2. Other Respiratory Infections: While Cebosh is primarily used for upper and lower respiratory tract infections, it might be considered off-label for other respiratory infections caused by susceptible bacteria.
3. Traveler’s Diarrhea: Cebosh could be used off-label for traveler’s diarrhea caused by susceptible bacterial pathogens, although other antibiotics might be more commonly recommended.
4. Chronic Obstructive Pulmonary Disease (COPD): There could be situations where Cebosh is used off-label in patients with COPD who develop bacterial respiratory infections.
5. Intra-Abdominal Infections: Off-label use of Cebosh could be considered for certain intra-abdominal infections caused by susceptible bacteria.

Cebosh Syrup is one of the leading brands of Cefixime in oral liquid form, manufactured and marketed by Bosch Pharmaceuticals (Pvt) Ltd, Pakistan.

The following are some alternative brands of Cebosh Syrup and their manufacturer.

Cefiget : Getz Pharmaceuticals (Pvt) Ltd, Pakistan.

Cefim : Hilton Pharmaceuticals (Pvt) Ltd, Pakistan.

Caricef : Sami Pharmaceuticals (Pvt) Ltd, Pakistan.

Cefspan : Barrett Hodgson Pakistan (Pvt) Ltd.

Fixitil : Tabros Pharma (Pvt) Ltd, Pakistan.

Icef : ICI Pakistan Ltd.

Linzim : Bosch Pharmaceuticals (Pvt) Ltd, Pakistan.

Magnett : S.J. & G Fazul Ellahie (Pvt) Ltd, Pakistan.

Maxima : Macter International (Pvt) Ltd.

Maxpan : Indus Pharma (Pvt) Ltd, Pakistan.

Omixim : Searle Pakistan (Pvt) Ltd.

Presently, Cebosh is available in Syrup, Tables, and Capsule forms.

Cebosh Syrup : 100mg/5ml strength.

Cebosh DS Syrup : 200mg/5ml strength.

Cebosh Tablet : 200mg and 400mg strengths.

Cebosh Capsule : 400mg strength.

Cebosh syrup, like any medication, has contraindications, which are specific situations or conditions in which the use of the medication is not recommended or should be avoided due to potential risks.

1. Hypersensitivity or Allergy: Individuals who have a known hypersensitivity or allergy to Cebosh, other cephalosporin antibiotics, or any of the components in the syrup should not take Cebosh, as it can lead to allergic reactions, ranging from mild skin rashes to severe anaphylactic reactions.
2. History of Severe Allergic Reactions: Individuals with a history of severe allergic reactions (anaphylaxis) to beta-lactam antibiotics (such as cephalosporins or penicillins) should avoid Cebosh.
3. Cross-Sensitivity: Cross-reactivity can occur between different beta-lactam antibiotics. If a patient has a known allergy to penicillins or other cephalosporins, there may be an increased risk of allergic reactions to Cebosh.
4. Renal Impairment: Cebosh is primarily eliminated through the kidneys. Individuals with severe renal impairment may require dosage adjustments or should avoid Cebosh altogether, as it can lead to increased levels of the drug in the body and potential toxicity.
5. Pregnancy and Breastfeeding: The safety of Cebosh use during pregnancy and breastfeeding has not been fully established. Pregnant or breastfeeding individuals should consult with a healthcare provider before using Cebosh.
6. Clostridium difficile-Associated Diarrhea: Cebosh use can disrupt the normal bacterial flora in the intestines and potentially lead to an overgrowth of Clostridium difficile bacteria, causing severe diarrhea and colitis.
7. Previous Severe Gastrointestinal Reactions: Individuals who have experienced severe gastrointestinal reactions (e.g., colitis) to antibiotics in the past should use Cebosh with caution.
8. Seizure Disorders: Cebosh can rarely lower the seizure threshold. Patients with a history of seizure disorders should be closely monitored if Cebosh is considered.
9. Gastrointestinal Disease: Individuals with a history of gastrointestinal diseases, particularly colitis, should use Cebosh with caution, as it can exacerbate these conditions.
10. Liver Disease: Cebosh is metabolized in the liver. Individuals with severe liver disease may require dosage adjustments or avoid Cebosh due to potential effects on liver function.

Cebosh Syrup Dose for Pediatric Patients:

1. Otitis Media, Pharyngitis, and Tonsillitis:
   • Children 6 months and older: The usual dose is 8 mg/kg/day, divided into two doses. The total daily dose should not exceed 400 mg.
2. Community-Acquired Pneumonia:
   • Children 6 months and older: The usual dose is 8 mg/kg/day, divided into two doses. The total daily dose should not exceed 400 mg.
3. Urinary Tract Infections:
   • Children 6 months and older: The usual dose is 8 mg/kg/day, divided into two doses. The total daily dose should not exceed 400 mg.

Cebosh Syrup Dose for Adults:

The recommended dose of cefixime syrup for adults can vary depending on the type and severity of the infection. However, the typical dosing range for adults is often similar to the following:

1. Upper Respiratory Tract Infections:
   • 400 mg daily, taken as a single dose or divided into two doses.
2. Lower Respiratory Tract Infections:
   • 400 mg daily, taken as a single dose or divided into two doses.
3. Urinary Tract Infections:
   • 400 mg daily, taken as a single dose or divided into two doses.

Cebosh is a third-generation cephalosporin antibiotic with a bactericidal mode of action. It works by interfering with the ability of bacteria to build and maintain their cell walls, which are crucial for their survival and structural integrity.

Bacterial cells are surrounded by a rigid cell wall that provides support and protection. This cell wall is primarily composed of peptidoglycan, a complex molecule that forms a mesh-like structure. Cebosh inhibits an enzyme called transpeptidase (also known as penicillin-binding protein), which is involved in the cross-linking of peptidoglycan chains. This cross-linking is essential for the strength and stability of the cell wall.

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