Zetro Syrup Uses

Zetro syrup is used to treat a variety of bacterial infections caused by susceptible microorganisms.  It is an antibiotic medicine that belongs to the macrolide class. Zetro Syrup formulation is mostly recommended for pediatric patients who may have difficulty swallowing tablets or capsules. The following are some common uses and indications of Zetro Syrup:

1. Respiratory Tract Infections: Zetro syrup is commonly used to treat respiratory tract infections, such as:
   • Pneumonia: Bacterial infections of the lungs.
   • Bronchitis: Inflammation of the bronchial tubes.
   • Sinusitis: Inflammation of the sinus cavities.
   • Pharyngitis and Tonsillitis: Infections of the throat and tonsils.
2. Ear Infections: Zetro syrup may be used to treat bacterial ear infections (otitis media) in children.
3. Skin and Soft Tissue Infections: Zetro syrup can be used for mild to moderate skin and soft tissue infections caused by susceptible bacteria.
4. Streptococcal Infections: Zetro syrup is effective against certain streptococcal infections, including strep throat (streptococcal pharyngitis).
5. Traveler’s Diarrhea: Zetro syrup can be used to treat certain cases of traveler’s diarrhea caused by bacterial infections.

Off-label Uses of Zetro Syrup

1. Cystic Fibrosis: Zetro syrup has been trialed for its potential benefits in managing lung infections and reducing inflammation in individuals with cystic fibrosis, a genetic disorder that affects the respiratory and digestive systems.
2. Chronic Obstructive Pulmonary Disease (COPD): Zetro syrup may be used as part of a treatment regimen for COPD exacerbations and to reduce the frequency of exacerbations in certain cases.
3. Acne: Some research has explored the use of Zetro syrup in combination with other treatments for acne, particularly in cases where acne is associated with certain bacterial infections.
4. Autoimmune and Inflammatory Conditions: Zetro syrup’s anti-inflammatory properties have led to investigations into its potential use for various autoimmune and inflammatory conditions, such as rheumatoid arthritis and interstitial lung diseases. It may help reduce inflammation and improve symptoms in some cases.
5. Prevention of Bacterial Infections: In some situations, Zetro syrup might be used as a preventive measure to reduce the risk of bacterial infections, such as in surgical procedures or in individuals with weakened immune systems.
6. Gastrointestinal Conditions: Zetro syrup has been explored for its potential anti-inflammatory effects in conditions like inflammatory bowel disease (IBD) and gastroesophageal reflux disease (GERD).
7. Dental Infections: Zetro syrup may be considered for dental infections caused by certain susceptible bacteria.
8. Other Bacterial Infections: Zetro syrup’s broad-spectrum activity has led to its investigation for treating various bacterial infections beyond the commonly approved indications.

Zetro Syrup is one of the leading brands of Azithromycin, manufactured and marketed by Getz Pharmaceuticals (Pvt) Ltd, Pakistan.

The following are some alternative brands of Zetro syrup and their manufacturers.

Azitma : Sami Pharmaceuticals, Pakistan.

Azomax : Novartis, Pakistan.

Macrobac : Asian Continental Pharmaceuticals, Pakistan.

Zyto : High-Q Pharmaceuticals (Pvt) Ltd, Pakistan.

Azotek : Saffron Pharmaceuticals, Pakistan.

Zezot : Bosch Pharmaceuticals, Pakistan.

Zithromax : Pfizer Pharmaceuticals.

Atizor : Macter International.

Exthro : Indus Pharmaceuticals, Pakistan.

Azitral : Nova Med Pharmaceuticals, Pakistan.

Rescue : Standpharm Pakistan (Pvt) Ltd.

Presently, Zetro is available in Syrup, Tablets, and Capsule, forms.

Zetro Syrup : 200mg/5ml strength

Zetro Tablet : 250mg, and 500mg strengths

Zetro Capsule : 250mg strength

Zetro is generally well-tolerated and effective. However, there are certain contraindications, or situations in which the use of Zetro is not recommended due to potential risks.

1. Hypersensitivity or Allergy: If you have a known hypersensitivity or allergy to Zetro syrup, other macrolide antibiotics, or any of the ingredients in the medication, you should avoid its use.
2. History of Liver Disease: Zetro syrup is metabolized by the liver, and individuals with a history of liver disease may require dose adjustments or careful monitoring while using the medication.
3. History of QT Prolongation: Zetro syrup, like other macrolide antibiotics, has been associated with a rare risk of QT interval prolongation, which can lead to a potentially life-threatening heart rhythm disorder. Individuals with a history of QT prolongation, heart rhythm disorders, or those taking medications that can prolong the QT interval should use Zetro syrup with caution.
4. Electrolyte Imbalance: Certain electrolyte imbalances, such as low levels of potassium or magnesium, can increase the risk of QT prolongation. Individuals with electrolyte imbalances should be cautious when using Zetro syrup.
5. Myasthenia Gravis: Zetro syrup may exacerbate symptoms of myasthenia gravis, a neuromuscular disorder characterized by muscle weakness.
6. Severe Kidney Dysfunction: Individuals with severe kidney dysfunction (renal impairment) may require dose adjustments or careful monitoring when using Zetro syrup.
7. Porphyria: Zetro syrup can potentially worsen symptoms of porphyria, a group of rare genetic disorders that affect the nervous system or skin.
8. Concomitant Medications: Zetro syrup can interact with other medications, potentially affecting their effectiveness or increasing the risk of side effects. It’s important to inform your healthcare provider of all medications you are taking, including over-the-counter drugs, supplements, and herbal products.
9. Pregnancy and Breastfeeding: While Zetro syrup is generally considered safe during pregnancy and breastfeeding, its use should be carefully considered and monitored by a healthcare provider.
10. Certain Cardiovascular Conditions: Zetro syrup may not be suitable for individuals with specific cardiovascular conditions. It’s important to discuss your medical history with your healthcare provider before using the medication.

Zetro Syrup Dose for Children (6 months to 12 years old):

• 10 mg/kg once daily for 3 days or 10 mg/kg as a single dose on day 1 followed by 5 mg/kg once daily on days 2 through 5 days.

Zetro Dose for Adults:

• 500 mg once daily for 3 days or 500 mg as a single dose on day 1 followed by 250 mg once daily on days 2 through 5 dyas.

Zetro enters bacterial cells and binds to the ribosomes, which are the cellular structures responsible for protein synthesis. Specifically, it binds to the 50S subunit of the bacterial ribosome. By binding to the ribosomes, Zetro disrupts the process of protein synthesis in bacteria. This prevents the bacteria from producing essential proteins necessary for their growth and survival.

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Zetro Side Effects