Maxolon Syrup Uses

Maxolon syrup is a medication that is primarily used to treat gastrointestinal conditions. It helps to increase the movement of the stomach and intestines, thereby relieving symptoms such as nausea, vomiting, and heartburn. The following are some common uses and indications of Maxolon Syrup:

1. Gastroesophageal Reflux Disease (GERD): Maxolon syrup is commonly used to manage the symptoms of GERD, a condition characterized by acid reflux and heartburn. It helps reduce the frequency and severity of symptoms by promoting the movement of food through the stomach and preventing acid reflux.
2. Nausea and Vomiting: Maxolon syrup is frequently used to relieve nausea and vomiting associated with various conditions, including:
   • Chemotherapy-induced nausea and vomiting: It can be given as part of an antiemetic regimen to help prevent or control chemotherapy-related nausea and vomiting.
   • Postoperative nausea and vomiting: Maxolon syrup may be administered after surgery to alleviate postoperative nausea and vomiting.
   • Migraine-associated nausea and vomiting: It can be used to alleviate symptoms of nausea and vomiting associated with migraines.
3. Gastroparesis: Gastroparesis is a condition in which the stomach takes longer than normal to empty its contents. Maxolon syrup can be used to improve stomach emptying and relieve symptoms such as bloating, nausea, and vomiting in individuals with gastroparesis.
4. Other Gastrointestinal Disorders: Maxolon syrup may be used in other gastrointestinal disorders, including:
   • Functional dyspepsia: It can help relieve symptoms of functional dyspepsias, such as discomfort or pain in the upper abdomen, bloating, and early satiety.
   • Intestinal obstruction: Maxolon syrup can be used to help manage symptoms of intestinal obstruction by promoting intestinal motility and reducing nausea and vomiting.

Off-label Uses of Maxolon Syrup

1. Diabetic Gastroparesis: Maxolon syrup may be used off-label to manage symptoms associated with diabetic gastroparesis, a condition characterized by delayed stomach emptying in individuals with diabetes. It can help improve gastric motility and reduce symptoms like nausea, vomiting, and bloating.
2. Irritable Bowel Syndrome (IBS): In some cases, Maxolon syrup may be used off-label to manage symptoms of IBS, a chronic disorder that affects the large intestine. It can help alleviate symptoms such as abdominal pain, bloating, and changes in bowel habits.
3. Cyclic Vomiting Syndrome (CVS): Maxolon syrup may be used off-label to help control symptoms of cyclic vomiting syndrome, a disorder characterized by recurrent episodes of severe vomiting. It can help reduce the frequency and severity of vomiting episodes.
4. Hiccups: Maxolon syrup may be used off-label in the management of persistent hiccups that are refractory to other treatments. It can help modulate the reflex responsible for hiccups and provide relief.
5. Gastrointestinal Motility Disorders: Maxolon syrup may be used off-label in other gastrointestinal motility disorders, such as functional dyspepsia, intestinal pseudo-obstruction, or chronic idiopathic intestinal pseudo-obstruction. It can help improve motility and relieve associated symptoms.

Maxolon Syrup is one of the leading brands of Metoclopramide in oral liquid form, manufactured and marketed by GlaxoSmithKline (GSK).

The following are some alternative brands of Maxolon Syrup and their manufacturers.

Metoclon : Indus Pharma (Pvt) Ltd, Pakistan.

Metomide : (CCL) Consolidated Chemical Laboratories (Pvt) Ltd, Pakistan.

Cloprel : Hamza Pharmaceutical (Pvt) Ltd, Pakistan.

M-Clon : Sharex Laboratories (Pvt) Ltd, Pakistan.

Metoca : Neutro Pharma (Pvt) Ltd, Pakistan.

Metolon : Mediceena Pharma (Pvt) Ltd, Pakistan.

Metopride : Atlantic Pharmaceuticals (Pvt) Ltd, Pakistan.

Metorex : Rex Pharmaceuticals, Pakistan.

Clopra : Neo-Medix, Pakistan.

Emetal : Elbro Pharma, Pakistan.

Presently, Maxolon is available in Syrup, tablet, and Injection forms.

Maxolon Syrup : 5mg/5ml strength.

Maxolon Tablet : 10mg strength.

Maxolon Injection : 5mg/ml strength.

Maxolon syrup, like any medication, has certain contraindications—specific situations or conditions in which the use of Maxolon is not recommended due to potential risks or adverse effects.

• Gastrointestinal Obstruction or Perforation: Maxolon syrup is contraindicated in individuals with gastrointestinal obstruction or perforation. It can potentially worsen these conditions by enhancing muscular contractions in the gastrointestinal tract, which may cause further complications.
• Pheochromocytoma: Maxolon syrup is contraindicated in individuals with a rare tumor called pheochromocytoma, which affects the adrenal glands. Maxolon may stimulate the release of hormones from the tumor, leading to a potentially dangerous increase in blood pressure.
• Seizure Disorders: Maxolon syrup should be used with caution or avoided in individuals with a history of seizure disorders or epilepsy. The medication can lower the seizure threshold and increase the risk of seizures in susceptible individuals.
• Parkinson’s Disease or Parkinsonian Symptoms: Maxolon syrup is contraindicated in individuals with Parkinson’s disease or Parkinsonian symptoms. The medication can worsen the symptoms of these conditions by interfering with dopamine activity in the brain.
• Adrenal Tumor (Prolactinoma): Maxolon syrup should not be used in individuals with an adrenal tumor known as prolactinoma. The medication can increase the production and release of prolactin, a hormone that can promote tumor growth.
• Hypersensitivity: Maxolon syrup is contraindicated in individuals who have a known hypersensitivity or allergic reaction to Maxolon or any of its components. Allergic reactions to Maxolon can range from mild to severe and may include symptoms such as rash, itching, swelling, difficulty breathing, or anaphylaxis.

Maxolon Syrup Dose for Nausea and Vomiting:

• Adults: 10 mg (10 ml of syrup) taken up to four times a day, with the maximum daily dose typically not exceeding 40 mg.
• Children (1 to 14 years old): The recommended dose is based on body weight and will be determined by a healthcare professional. It is typically around 0.1 to 0.15 mg per kg of body weight, given three to four times a day.

Maxolon Syrup Dose for Gastroesophageal Reflux Disease (GERD):

• • Adults: 10 mg (10 ml of syrup) taken four times a day, usually 15 to 30 minutes before meals and at bedtime.
  • Children (1 to 14 years old): The recommended dose is based on body weight and will be determined by a healthcare professional. It is typically around 0.1 to 0.2 mg per kilogram of body weight, given four times a day.

Maxolon works by increasing the movement of food through the stomach and intestines. Maxolon blocks dopamine D2 receptors in the brain and gut. Dopamine is a neurotransmitter that plays a role in nausea and vomiting. By blocking dopamine receptors, it prevents the brain from sending signals that cause nausea and vomiting.

Maxolon also works by increasing the release of acetylcholine, a neurotransmitter that stimulates the movement of food through the stomach and intestines. This helps to speed up the emptying of the stomach and intestines, which can help to relieve nausea and vomiting.