Hepa Merz Syrup Uses

Hepa Merz syrup is a medication that combines two amino acids. Hepa Merz is primarily used in the management of hepatic encephalopathy, a condition characterized by brain dysfunction that occurs as a result of severe liver disease. The following are some common uses of Hepa Merz Syrup:

1. Hepatic Encephalopathy: Hepa Merz syrup is commonly used as part of the treatment for hepatic encephalopathy. This condition occurs when the liver is unable to adequately process ammonia, leading to its accumulation in the bloodstream. Hepa Merz syrup helps in the detoxification of ammonia, reducing its levels and helping to alleviate symptoms of hepatic encephalopathy, such as confusion, cognitive impairment, and altered consciousness.
2. Liver Disease: Hepa Merz syrup may be used as a supportive treatment for various liver diseases, including chronic liver diseases like cirrhosis and hepatitis. It is believed to improve liver function and aid in the detoxification processes.
3. Fatigue and Weakness: In some cases, Hepa Merz syrup may be prescribed to alleviate symptoms of fatigue and weakness associated with liver diseases.

Off-label Uses of Hepa Merz Syrup

1. Non-Alcoholic Fatty Liver Disease (NAFLD): NAFLD is a condition characterized by the accumulation of fat in the liver. While there is limited clinical evidence, some healthcare professionals may consider prescribing Hepa Merz syrup off-label as a supportive treatment for NAFLD, aiming to improve liver function.
2. Drug-Induced Liver Injury: Hepa Merz syrup may be used off-label in cases of drug-induced liver injury. The L-ornithine-L-aspartate in the syrup is believed to promote liver detoxification and assist in the recovery process.
3. Chronic Hepatitis: In some cases of chronic hepatitis, Hepa Merz syrup may be prescribed off-label to support liver function and potentially alleviate symptoms such as fatigue and weakness.
4. Alcoholic Hepatitis: Hepa Merz syrup could be considered off-label as a supportive treatment in cases of alcoholic hepatitis, aiming to improve liver function and aid in the detoxification processes.

Hepa Merz Syrup is one of the leading brands with the combination of L-Ornithine and L-Aspartate in oral liquid form, manufactured and marketed by Brookes Pharmaceutical Laboratories (Pak) Ltd.

The following are some alternative brands of Hepa Merz Syrup and their manufacturers.

• Levijon : Sami Pharmaceuticals (Pvt) Ltd, Pakistan.
• Enerviv : Genix Pharmaceuticals (Pvt) Ltd, Pakistan.

Some other brands, are not similar in composition to Hepa Merz Syrup but these brands are also used for Liver Diseases.

• Jetepar : Poplular Chemical Works (Pvt) Ltd, Pakistan.

Presently, Hepa Merz is available in Syrup, Infusion, and Granules forms.

Hepa Merz Syrup : L-Ornithine L-Aspartate 300mg/5ml strength.

Hepa Merz Infusion : 500mg/5ml strength.

Hepa Merz Granules : 3g/sachet.

Hepa-Merz syrup has a few contraindications, which are specific situations or conditions in which the use of Hepa Merz is not recommended.

1. Hypersensitivity: The syrup should not be used in individuals who have a known hypersensitivity or allergy to L-ornithine-L-aspartate or any other component of the medication. Allergic reactions may range from mild skin rashes to severe reactions that require immediate medical attention.
2. Severe Renal Impairment: Hepa Merz syrup is primarily metabolized in the kidneys, and its safety and efficacy have not been established in individuals with severe renal impairment. Therefore, it is contraindicated in patients with severe renal impairment (creatinine clearance less than 30 mL/min).
3. Acute Liver Failure: The use of Hepa Merz syrup is not recommended in cases of acute liver failure, as it may not be effective in treating this condition.
4. Severe Metabolic Disorders: The syrup should be used with caution in individuals with severe metabolic disorders, such as urea cycle disorders, due to the potential risk of exacerbating these conditions.

1. Hepa Merz Syrup Dose for Hepatic Encephalopathy:
   • Adults: The typical recommended dosage is 30 mL (2 tablespoons) of Hepa Merz syrup three times a day.
   • Children: The dosage for children may vary depending on their age, weight, and the severity of the condition. It is best determined by a healthcare professional.
2. Hepa Merz Syrup Dose for Supportive Treatment in Liver Disease:
   • The recommended dosage may vary depending on the specific liver condition and the individual patient’s needs. It is usually prescribed as 10-30 mL (2 teaspoons to 2 tablespoons) of Hepa Merz syrup two to three times a day.

Hepa-Merz syrup contains the active ingredients L-ornithine-L-aspartate, which work together to support liver function and metabolism. The mode of action of Hepa Merz syrup is primarily related to its effects on ammonia detoxification and the urea cycle in the liver.