Tixylix Syrup Uses

Texylix Syrup is a medication with a combination of an anti-allergy and a cough suppressant. It is primarily used to relieve cough symptoms associated with respiratory conditions in children. The following are some common uses of Tixylix Syrup:

1. Cough Suppression: Tixylix syrup is used to suppress or relieve coughing. It acts on the cough center in the brain, reducing the urge to cough. It provides symptomatic relief for dry, non-productive coughs.
2. Allergy Relief: The use of Tixylix syrup helps alleviate symptoms associated with allergies, such as itching, sneezing, runny nose, and watery eyes. It works by blocking the effects of histamine, a substance released during an allergic reaction.
3. Allergic Cough: Tixylix syrup may also be used for the treatment of allergic cough caused by allergies or irritants. It can help suppress coughing episodes triggered by exposure to allergens such as dust, pollen, or pet dander.
4. Sedation: Tixylix syrup also has sedative properties, which can be beneficial in certain situations. It can help induce sleep or promote relaxation, especially in cases where coughing or allergies may interfere with restful sleep.

Off-label Uses of Tixylix Syrup

1. Sore Throat Relief: Tixylix syrup’s soothing properties may provide relief for sore throat symptoms in children. It can help ease discomfort and reduce irritation caused by a sore or scratchy throat.
2. Throat Irritation: Tixylix syrup’s demulcent action may be used off-label to alleviate throat irritation caused by various factors, such as dryness, mild inflammation, or excessive talking or yelling.
3. Dry Cough: Tixylix syrup’s lubricating effect on the throat may be beneficial for relieving dry, non-productive coughs in children. It can help soothe the throat and reduce the frequency and intensity of coughing episodes.
4. Postnasal Drip: Tixylix syrup’s demulcent properties may be used off-label to provide relief from coughing associated with postnasal drip. It can help coat the throat and alleviate the irritation caused by excessive mucus draining from the nasal passages to the back of the throat.
5. Nausea and Vomiting: Tixylix syrup can help alleviate nausea and vomiting. It may be used off-label in situations where other antiemetic options have been ineffective or are not suitable.

Tixylix Syrup is one of the leading brands of Promethazine HCl + Pholcodine in oral liquid form, manufactured and marketed by Sanofi Aventis (Pakistan) Ltd.

The following are some available alternative brands of Tixylix Syrup and their manufacturers.

• Rintal : Stanley Pharmaceuticals (Pvt) Ltd, Pakistan.
• Combinol (Junior) : Atco Laboratories Ltd, Pakistan.
• Pedilix : Werrick Pharmaceuticals, Pakistan.
• Folcozine : Scotmann Pharmaceuticals, Pakistan.
• Chixicol : Libra Pharmaceuticals (Pvt) Ltd, Pakistan.
• Allerplex : Pliva Pakistan (Pvt) Ltd.

Presently, Tixylix is available in Syrup form.

Tixylix Syrup each 5ml contains:

• Promethazine HCl: 1.5mg
• Pholcodine : 1.5mg

Tixylix Syrup has certain contraindications, which are specific situations or conditions where the use of Tixylix is not recommended due to the potential risks involved.

Hypersensitivity or Allergy: Tixylix syrup should not be used in individuals who have a known hypersensitivity or allergy to promethazine, pholcodine, or any of the other ingredients in the syrup. Allergic reactions can range from mild to severe and may include symptoms such as rash, itching, swelling, or difficulty breathing.

Asthma or Chronic Obstructive Pulmonary Disease (COPD): The use of Tixylix syrup may be contraindicated in individuals with asthma or COPD, as it may cause increased bronchial constriction and respiratory depression.

Central Nervous System (CNS) Depression: Tixylix syrup should be used with caution or avoided in individuals with CNS depression, such as those with a head injury, brain tumor, or certain respiratory disorders. The medication can have sedative effects and may further depress the central nervous system, leading to impaired breathing and decreased consciousness.

Acute Alcohol Intoxication: Tixylix syrup with alcohol can have additive sedative effects and may result in excessive CNS depression. Therefore, it is contraindicated in individuals with acute alcohol intoxication.

Neonates and Premature Infants: Tixylix syrup is generally contraindicated in neonates and premature infants due to the potential for increased sensitivity to the medication and the risk of respiratory depression.

Liver Disease: Tixylix Syrup may be contraindicated or require caution in individuals with severe liver disease. Liver impairment can affect the metabolism and clearance of the medication, leading to increased levels in the body.

Tixylix Syrup Dose for Adults and Children (over 12 years old):

• 5-10 ml (1-2 teaspoons), three to four times per day.
• However, the exact dosage may vary depending on the individual’s response to the medication and the severity of symptoms.

Tixylix Syrup Dose for Children (6-12 years old):

• 2.5-5 ml (1/2-1 teaspoon), three to four times per day.
• The specific dosage may be adjusted based on the child’s condition and response to treatment.

Tixylix Syrup Dose for Toddler (1 to 5 years):

• Dose: 5 ml to 10 ml (one to two 5 ml spoonfuls)
• Frequency: Give the dose 3 to 4 times a day as needed

Tixylix Syrup Dose for Infant (3 months to 1 year):

• Dose: 2.5 ml to 5 ml (half to one 5 ml spoonful)
• Frequency: Give the dose 3 to 4 times a day as needed

The mode of action of Tixylix depends upon its active ingredients. Here’s a brief overview of their individual modes of action:

1. Promethazine: Promethazine is an antihistamine with several properties that contribute to its therapeutic effects. Its main mechanisms of action include:
   • Antihistamine Effect: Promethazine blocks the effects of histamine, a chemical released during allergic reactions. By blocking histamine receptors, it helps alleviate symptoms such as itching, sneezing, runny nose, and watery eyes.
   • Sedative Effect: Promethazine has sedative properties, meaning it can induce relaxation and sleepiness. It acts on certain receptors in the brain, reducing brain activity and promoting sedation.
   • Antiemetic Effect: Promethazine also possesses antiemetic properties, which means it can help prevent or relieve nausea and vomiting. It acts on different receptors in the brain, blocking signals that trigger the vomiting reflex.
2. Pholcodine: Pholcodine is an antitussive agent, which means it is used to suppress coughing. Its mode of action involves:
   • Cough Suppression: Pholcodine acts on the cough center in the brain, reducing the sensitivity of the cough reflex. It helps suppress dry, non-productive coughs and can provide relief from cough symptoms.