Hydryllin Syrup Uses

Hydryllin syrup is a medication that is used for the treatment of respiratory conditions such as asthma, chronic obstructive pulmonary disease (COPD), and bronchitis. The following are some approved and off-label uses of Hydryllin Syrup:

Approved Uses of Hyderlin Syrup

1. Bronchodilation: The active ingredients of Hydryllin syrup, work together to relax the smooth muscles in the airways, which helps to widen the bronchial passages. This bronchodilatory effect allows for easier breathing and relief of symptoms associated with conditions like asthma and COPD.
2. Asthma: Hydryllin syrup is commonly used for the management of asthma, a chronic respiratory condition characterized by bronchospasm (narrowing of the airways), wheezing, coughing, and shortness of breath. By promoting bronchodilation, Hydryllin syrup helps to alleviate these symptoms and improve lung function.
3. Chronic Obstructive Pulmonary Disease (COPD): COPD is a progressive lung disease that encompasses chronic bronchitis and emphysema. Hydryllin syrup can be used as part of the treatment plan to relieve symptoms such as shortness of breath, wheezing, and coughing in individuals with COPD.
4. Bronchitis: Hydryllin syrup may also be used in the treatment of acute bronchitis, an inflammation of the bronchial tubes typically caused by a viral or bacterial infection. It helps to open up the airways, reduce bronchospasm, and ease breathing.

Off-label Uses of Hydryllin Syrup

1. Exercise-Induced Bronchoconstriction: Hydryllin syrup may be used off-label to manage exercise-induced bronchoconstriction, also known as exercise-induced asthma. It can be taken prior to physical exertion to prevent or reduce bronchospasm triggered by exercise.
2. Respiratory Distress Syndrome (RDS) in Premature Infants: In some cases, Hydryllin syrup may be used off-label in premature infants with respiratory distress syndrome (RDS). It can help improve breathing and enhance lung function in these infants by promoting bronchodilation.
3. Nasal Congestion: Due to the decongestant properties of ephedrine, which is one of the active ingredients in Hydryllin syrup, it may be used off-label to alleviate nasal congestion caused by allergies, colds, or sinusitis. However, caution should be exercised, and healthcare professional guidance is essential.
4. Chronic Cough: Hydryllin syrup may be used off-label to help relieve chronic cough caused by conditions such as postnasal drip, sinusitis, or bronchial irritation. The bronchodilatory effect of theophylline and ephedrine can help reduce coughing episodes.

Hydrylline is one of the leading brands with the combination of Aminophylline + Diphenhydramine Hcl + Ammonium Chloride + Menthol in liquid form. Hydryllin syrup is manufactured and marketed by Searle Pakistan (Pvt) Ltd.

The following are Some Alternative Brands of Hydryllin Syrup and Their Manufacturers.

• Cosome-E : Martin Dow Marker (Pvt) Ltd, Pakistan.
• Combinol-E : Atco Laboratories Ltd, Pakistan.
• Lotus : Indus Pharma (Pvt) Ltd, Pakistan.
• Coldrex-E : Standpharm Pakistan (Pvt) Ltd.
• Adalin : Macter International (Pvt) Ltd, Pakistan.
• Rexyl : Nabiqasim Industries (Pvt) Ltd, Pakistan.
• Cofllin : Bio Labs (Pvt) Ltd, Pakistan.
• Broxol : Stanley Pharmaceuticals (Pvt) Ltd, Pakistan.
• Standryllin : Standard Drud Co, Pakistan
• Bronil : Star Laboratories (Pvt) Ltd, Pakistan.

Presently, Hydryllin is available in Syrup Form.

Hydryllin Syrup Each 5ml Contains:

• Aminophylline: 32mg
• Diphenhydramine Hcl: 8mg
• Ammonium Chloride: 30mg
• Menthol: 0.98mg

Hydryllin DM Syrup Each 5ml Contains:

• Diphenhydramine HCL: 5mg
• Dextromethorphan Hydrobromide: 6.25mg

Contraindications are specific situations or conditions in which the use of Hydryllin syrup is not recommended due to potential risks or adverse effects.

1. Hypersensitivity or allergy: Individuals who have a known hypersensitivity or allergy to theophylline, ephedrine, or any other components of Hydryllin syrup should not use this medication.
2. Severe cardiovascular disease: Hydryllin syrup is contraindicated in individuals with severe cardiovascular diseases, including severe hypertension (high blood pressure), severe coronary artery disease, arrhythmias, or a history of heart attack.
3. Hyperthyroidism: Hydryllin syrup should not be used in individuals with hyperthyroidism, a condition characterized by an overactive thyroid gland. Theophylline in Hydryllin syrup can further stimulate the thyroid gland and worsen the symptoms.
4. Peptic ulcer disease: The use of Hydryllin syrup is contraindicated in individuals with active peptic ulcer disease, as the medication can increase gastric acid secretion and potentially worsen the condition.
5. Seizure disorders: Hydryllin syrup should be used with caution in individuals with a history of seizures or epilepsy, as theophylline may lower the seizure threshold and increase the risk of seizure activity.
6. Recent myocardial infarction (heart attack): Individuals who have experienced a recent heart attack should avoid using Hydryllin syrup due to potential adverse effects on the cardiovascular system.
7. Pregnancy and breast-feeding: The use of Hydryllin syrup during pregnancy and breastfeeding should be discussed with a healthcare professional. Theophylline and ephedrine can cross the placenta and pass into breast milk, potentially affecting the fetus or infant.

.

Hydryllin Syrup Dose for Adults:

• Starting Dose: 5 ml (1 teaspoon) of Hydryllin syrup, taken orally every 4 to 6 hours.
• The maximum daily dose should not exceed 20 ml (4 teaspoons).

Hydryllin Syrup Dose for Children:

• Starting Dose: 2.5 ml (½ teaspoon), and can be adjusted as necessary.

Hydryllin Syrup is a combination of four different ingredients and the mode of action is depending on its active ingredients as follows.

1. Aminophylline:
   It is a bronchodilator that belongs to the class of methylxanthine compounds. It works by relaxing the smooth muscles of the airways and bronchial tubes. Aminophylline acts as a phosphodiesterase inhibitor, which leads to increased levels of cyclic adenosine monophosphate (cAMP) within the cells. Elevated cAMP levels help dilate the bronchial tubes, allowing for improved airflow and relief of respiratory symptoms associated with conditions like asthma and bronchitis.
2. Diphenhydramine HCl:
   It is an antihistamine that primarily works by blocking the effects of histamine, a substance released during an allergic reaction. By inhibiting the activity of histamine, diphenhydramine helps to reduce allergy symptoms such as sneezing, itching, runny nose, and watery eyes. It also has sedative properties, which can help with sleep disturbances associated with cough and cold.
3. Ammonium chloride:
   It is an expectorant that helps to thin and loosen mucus in the respiratory tract. It works by increasing the volume and reducing the viscosity of respiratory secretions, making it easier to cough up and clear the airways. By facilitating the removal of excess mucus, ammonium chloride helps relieve congestion and promotes productive coughing.
4. Menthol:
   It is a compound that provides a cooling sensation and acts as a mild anesthetic. When applied topically or inhaled, menthol produces a local anesthetic effect, temporarily relieving minor throat and nasal irritation. It also helps to soothe cough reflexes and provides a sense of relief by numbing the throat and nasal passages.