Lowplat Plus Tablet Uses

Lowplat Plus is primarily used to reduce the risk of cardiovascular disease and stroke in those at high risk. It is a combination of two antiplatelet drugs that are used to prevent platelet aggregation. Following are some common uses of Lowplat Plus Tablet:

1. Acute Coronary Syndrome (ACS): Lowplat Plus tablet is commonly used in the management of acute coronary syndrome, which includes conditions like unstable angina and myocardial infarction (heart attack). This dual antiplatelet therapy helps prevent blood clot formation and reduces the risk of subsequent cardiovascular events.
2. Percutaneous Coronary Intervention (PCI): Lowplat Plus tablet is also used after percutaneous coronary intervention, such as angioplasty or stent placement. Using Lowplat Plus helps prevent clotting inside the stent or the narrowed coronary arteries, reducing the risk of restenosis (re-narrowing) and recurrent cardiovascular events.
3. Secondary Prevention of Cardiovascular Events: Lowplat Plus tablets may be used in patients who have experienced a previous cardiovascular event, such as a heart attack or stroke, to reduce the risk of future events. Using Lowplat Plus helps inhibit platelet aggregation and prevents the formation of blood clots that can lead to heart attacks, strokes, or other vascular events.

Off-label Uses of Lowplat Plus Tablet

1. Peripheral Arterial Disease (PAD): Lowplat Plus tablets may be used off-label for the management of peripheral arterial disease, which is characterized by reduced blood flow to the limbs. Lowplat Plus therapy may help reduce the risk of blood clot formation and improve circulation in affected arteries.
2. Atrial Fibrillation: Lowplat Plus tablets may be considered in certain situations for patients with atrial fibrillation who are unable to tolerate or have contraindications to oral anticoagulant therapy.

Lowplat Plus is a combination of Clopidogrel and Aspirin, manufactured and marketed by Pharmevo Pakistan (Pvt) Ltd.

The following are some alternative brands of Lowplat Plus and their manufacturers.

• Ascard Plus : Atco Laboratories Ltd, Pakistan.
• Norplat S : Scilife Pharmaceuticals (Pvt) Ltd, Pakistan.
• Pidogrel AP : Highnoon Laboratories Ltd, Pakistan.
• Clotni Plus : Berrett Hodgson Pakistan (Pvt) Ltd, Pakistan.
• Plagril Plus : Saffron Pharmaceuticals (Pvt) Ltd, Pakistan.
• Clopid ASP : Ferozsons Laboratories Ltd, Pakistan.
• Platrid AP : Sami Pharmaceuticals (Pvt) Ltd, Pakistan.
• Ogrel Plus 81 : Bosch Pharmaceuticals (Pvt) Ltd, Pakistan.
• Noclot-EA : (CCL) Consolidated Chemical Laboratories (Pvt) Ltd, Pakistan.
• Enclot Plus : Pharma Health Pakistan (Pvt) Ltd, Pakistan.

Presently, Lowplat Plus is available in Tablet Form with the following strengths.

Lowplat Plus Tablet : Clopidogrel 75mg + Aspirin 75mg strengths.

Lowplat Tablet : Clopidogrel 75mg strength.

Lowplat Plus may not be suitable for everyone, and there are certain contraindications and precautions to consider.

Hypersensitivity or Allergy: Lowplat Plus is contraindicated in individuals who have a known hypersensitivity or allergy to either of the medications or any of their components.

Active Bleeding: Lowplat Plus should be avoided in individuals with active bleeding disorders or a history of bleeding. Lowplat Plus can increase the risk of bleeding, and their use may exacerbate bleeding conditions or interfere with hemostasis (blood clotting).

Severe Liver Disease: Lowplat Plus contains Clopidogrel and which is metabolized in the liver, and severe liver disease may affect its metabolism and clearance from the body. In such cases, the use of clopidogrel should be approached with caution or avoided, as its safety and effectiveness may be compromised.

Severe Renal Impairment: Lowplat Plus may require dose adjustments or be contraindicated in individuals with severe renal impairment (kidney disease). Impaired kidney function can affect the clearance of these medications from the body, potentially increasing their levels and the risk of adverse effects.

Peptic Ulcer Disease: Lowplat Plus also contains Aspirin, which can increase the risk of gastrointestinal bleeding and worsen peptic ulcers. Clopidogrel, in combination with aspirin, may further increase this risk. Individuals with a history of peptic ulcer disease or gastrointestinal bleeding should be carefully assessed, and alternative treatment options may be considered.

Pregnancy and Breastfeeding: Lowplat Plus should be used with caution during pregnancy and breastfeeding. Lowplat plus may have potential risks to the developing fetus or nursing infant. The use of this medication in pregnant or breastfeeding individuals should be discussed with a healthcare professional to weigh the potential benefits against the potential risks.

Drug Interactions: Lowplat Plus may interact with certain medications, including other blood-thinning agents, nonsteroidal anti-inflammatory drugs (NSAIDs), and proton pump inhibitors (PPIs). It is important to inform your healthcare professional about all the medications you are taking, including over-the-counter drugs and herbal supplements, to avoid potential interactions.

Lowplat Plus Dose for Acute Coronary Syndrome (ACS):

• 1 to 3 Tablets of Lowplat Plus, once a day or in divided three doses.
• The maximum Daily dose: Four Tablets per day.

Lowplat Plus Dose for Percutaneous Coronary Intervention (PCI):

• 1 to 2 Tablets, Thrice a day.
• The duration of dual antiplatelet therapy (clopidogrel and aspirin) after PCI is usually determined by the healthcare professional based on individual patient factors.

Lowplat Plus Dose for Secondary Prevention of Cardiovascular Events:

• One Tablet, Once a day.

Lowplat Plus’s ingredients work synergistically to prevent blood clot formation and reduce the risk of cardiovascular events. Its mode of action depends on its active ingredients.

1. Clopidogrel (an active Ingredient of Lowplat Plus): It is an antiplatelet medication that belongs to a class of drugs known as P2Y12 receptor inhibitors. Its mode of action involves the following steps:

• Activation: After oral administration, clopidogrel is converted into its active form by enzymes in the liver. This active form selectively and irreversibly binds to the P2Y12 receptors on platelets, which are responsible for platelet activation.
• Platelet Inhibition: By binding to the P2Y12 receptors, clopidogrel inhibits platelet activation and aggregation. This reduces the ability of platelets to clump together and form blood clots.
• Preventing Thrombus Formation: The inhibition of platelet activation and aggregation by clopidogrel helps to prevent the formation of arterial thrombi, which can lead to conditions such as myocardial infarction or stroke.

2. Aspirin(another active Ingredient of Lowplat Plus): It is a nonsteroidal anti-inflammatory drug (NSAID) with antiplatelet properties. Its mode of action involves the following mechanisms:

• Cyclooxygenase Inhibition: Aspirin irreversibly inhibits the enzyme cyclooxygenase (COX), specifically COX-1. COX-1 is involved in the production of prostaglandins, which promote platelet aggregation and contribute to the formation of blood clots.
• Thromboxane A2 Inhibition: By inhibiting COX-1, aspirin reduces the synthesis of thromboxane A2, a potent platelet activator and vasoconstrictor. Thromboxane A2 promotes platelet aggregation and is involved in the amplification of platelet activation signals.
• Antiplatelet Effects: The inhibition of thromboxane A2 production and other prostaglandins by aspirin leads to reduced platelet activation and aggregation. This helps to prevent the formation of blood clots and maintains blood flow through the arteries.

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