Voniza Tablet Uses

Vonza tablet is a medication used to treat certain stomach and esophagus problems, particularly conditions related to excess stomach acid. It belongs to the class of PPIs  (proton pump inhibitors). Following are some common and off-label uses of Voniza tablets:

Common Uses of Voniza Tablet

1. Gastroesophageal Reflux Disease (GERD): Voniza tablet is used to relieve symptoms and promote healing of the esophagus in individuals with GERD. It reduces the production of stomach acid, thereby reducing the acidity and irritation that can lead to heartburn, acid reflux, and damage to the esophagus.
2. Gastric Ulcers: Voniza tablet is prescribed to heal gastric ulcers, which are open sores that develop in the lining of the stomach. By inhibiting acid production, it helps to reduce the acidity in the stomach, allowing the ulcer to heal quickly.
3. Duodenal Ulcers: Duodenal ulcers are ulcers that develop in the first part of the small intestine, called the duodenum. Voniza tablet is used to treat duodenal ulcers by suppressing acid production, promoting healing, and reducing the risk of complications.
4. Helicobacter Pylori Infection: Voniza tablet is often used in combination with antibiotics to eradicate Helicobacter pylori (H. pylori) bacteria, which are associated with the development of gastric and duodenal ulcers. Voniza helps to reduce stomach acid levels, enhancing the effectiveness of antibiotics in eradicating bacteria.
5. Zollinger-Ellison Syndrome: Voniza tablets may be used for individuals with Zollinger-Ellison Syndrome, a rare condition characterized by the overproduction of stomach acid. It helps control excessive acid production and manage associated symptoms such as abdominal pain, diarrhea, and gastroesophageal reflux.

Off-label Uses of Voniza Tablet

1. NSAID-Induced Gastrointestinal Damage: Voniza tablet is used off-label to protect against gastric and duodenal damage caused by the long-term use of NSAIDs, which can increase the risk of ulcers and bleeding in the digestive tract.
2. Refractory GERD: Refractory GERD refers to cases where GERD symptoms persist despite treatment with standard PPIs. Voniza tablet is used as an alternative therapy for refractory GERD due to its potent and prolonged acid suppression.

Voniza is one of the leading brands of Vonoprazan, manufactured and marketed by Hilton Pharmaceuticals (Pvt) Ltd, Pakistan.

The following are some alternative brands of Voniza and their manufacturers.

• Vonozan : Getz Pharmaceuticals (Pvt) Ltd, Pakistan.
• VPN-10 : Helix Pharmaceuticals (Pvt) Ltd, Pakistan.
• Vonseca : Tabros Pharma, Pakistan.
• Vonnap : Highnoon Laboratories (Pvt) Ltd, Pakistan.

Presently, Voniza is available in tablet Form with the following strengths.

Voniza Tablets: 10mg and 20mg strengths.

Voniza has certain contraindications, meaning there are circumstances or conditions where its use is not recommended due to potential risks or adverse effects.

• Hypersensitivity: Voniza is contraindicated in individuals who have a known hypersensitivity or allergic reaction to Voniza or any of its components. Signs of a hypersensitivity reaction may include rash, itching, swelling, dizziness, or difficulty breathing.
• Concomitant use with certain medications: Voniza may interact with certain medications, and concomitant use should be avoided or closely monitored. For example, Voniza can interact with drugs that are metabolized by the liver’s cytochrome P450 enzyme system, potentially affecting their efficacy or increasing the risk of side effects.
• Pregnancy and breast-feeding: The safety of Voniza’s use during pregnancy and breastfeeding has not been established. It is generally recommended to avoid Voniza during pregnancy unless the potential benefits outweigh the risks. If you are breastfeeding or planning to become pregnant, it is essential to consult with a healthcare professional before using Voniza.
• Pediatric use: The safety and effectiveness of Voniza in children under the age of 18 have not been established. Voniza is not typically recommended for pediatric use unless specifically prescribed by a healthcare professional with expertise in pediatric gastroenterology.

Voniza Dose for Gastroesophageal Reflux Disease (GERD):

• One Tablet of 20mg once daily.
• The duration of treatment may vary depending on the severity of symptoms and the individual’s response to therapy.

Voniza Dose for Gastric and Duodenal Ulcers:

• One Tablet of 20mg once daily.
• The duration of treatment may vary depending on the size and location of the ulcer but typically ranges from 4 to 8 weeks.

Voniza Dose for Helicobacter Pylori Eradication:

• One Tablet of 20mg twice daily in combination with specific antibiotics.
• The duration of treatment may vary but commonly lasts for 7 to 14 days.

Voniza is a proton pump inhibitor (PPI) that works by suppressing gastric acid secretion in the stomach. Its mode of action involves inhibiting the enzyme H+/K+-ATPase, which is responsible for the final step in acid production within the stomach.