Pelton C Tablet Uses

Pelton C tablet is primarily used to manage certain gastrointestinal and vestibular disorders. It is a combination medication that provides two distinct effects, gastrointestinal motility regulation and antihistamine. Pelton C tablet can be used in the following indications:

1. Gastrointestinal Disorders: Pelton C is often used to treat gastrointestinal disorders such as delayed gastric emptying, gastroesophageal reflux disease (GERD), and functional dyspepsia.
2. Nausea and Vomiting: Pelton C is a medication that helps control nausea and vomiting by blocking dopamine receptors in the brain and gastrointestinal tract
3. Motion Sickness: Pelton C is commonly used to prevent and treat motion sickness, which can occur during travel, particularly by car, boat, or airplane.
4. Vertigo and Vestibular Disorders: Vertigo refers to a sensation of spinning or dizziness, often caused by problems in the inner ear. Pelton C may be used to manage vertigo and related vestibular disorders by reducing dizziness, imbalance, and associated symptoms.

Off-label Uses of Pelton C Tablet

1. Migraine-Associated Nausea and Vomiting: Migraine headaches are often accompanied by nausea and vomiting. Pelton C may be used off-label to alleviate these symptoms in individuals with migraines.
2. Chemotherapy-Induced Nausea and Vomiting (CINV): Pellton C tablets might be used off-label to manage nausea and vomiting caused by chemotherapy. However, there are other medications specifically approved for CINV that are often preferred.
3. Meniere’s Disease: Meniere’s disease is a disorder of the inner ear characterized by episodes of vertigo, hearing loss, tinnitus, and a feeling of fullness in the ear. Pelton C may be used off-label to help alleviate symptoms associated with Meniere’s disease.

Pelton C is one of the leading brands with the combination of Domperidone + Cinnarizine, manufactured and marketed by Global Pharmaceuticals (Pvt) Ltd, Pakistan.

The following are some available alternative brands of Pelton C and their manufacturers.

• Ri-One C : Panacea Pharmaceuticals.
• Dommed-C : Medley Pharmaceuticals, Pakistan.
• Domcin : Everest Pharmaceuticals, Pakistan.
• Domzine : Cherwel Pharmaceuticals (Pvt) Ltd, Pakistan.
• Vomidone : Medera Pharmaceuticals (Pvt) Ltd, Pakistan.

Presently, Pelton is available in Tablets and Suspension Forms with the following strengths.

Pelton C Tablet : Domperidone 19.1mg + Cinnarizine 20mg strength.

Pelton V Tablet : Domperidone 12.72mg strength.

Pelton V Suspension : Domperidone 1mg/ml strength.

Pelton C may not be suitable for everyone, and there are some contraindications to consider before using Pelton C.

• Hypersensitivity: Individuals who have a known hypersensitivity or allergy to domperidone, cinnarizine, or any other components of Pelton C should not use it.
• Prolactin-Related Conditions: Pelton C contains Domperidone is known to increase levels of the hormone prolactin. Therefore, it is contraindicated in individuals with known or suspected prolactinoma (prolactin-secreting pituitary tumor) or other conditions related to elevated prolactin levels.
• Severe Liver Dysfunction: Domperidone is primarily metabolized in the liver, and cinnarizine is also partially metabolized by the liver. Pelton C may be contraindicated in individuals with severe liver dysfunction as they could potentially worsen the condition or lead to adverse effects.
• Parkinson’s Disease: Pelton C also has dopamine antagonist properties, which may worsen the symptoms of Parkinson’s disease or cause extrapyramidal symptoms. Therefore, it is contraindicated in individuals with Parkinson’s disease or a history of drug-induced parkinsonism.
• QT Prolongation: Pelton C has the potential to prolong the QT interval, which can increase the risk of serious heart rhythm abnormalities. Therefore, this medication is contraindicated in individuals with a history of QT prolongation or certain cardiac conditions, such as congenital long QT syndrome.
• Children under 5 years of age: Pelton C is generally not recommended for use in children under 5 years of age due to limited safety data and concerns about cardiac effects.

Pelton C Dose for Motion Sickness:

• One or a half Tablet, 1 to 2 hours before travel.
• The dose may be repeated after 6-8 hours if needed, but the total daily dose should not exceed the recommended maximum.

Pelton C Dose for Vertigo and Balance Disorders:

• One Tablet of Pelton C Once or twice daily depending on the condition.
• The dose may be adjusted based on the individual’s response and tolerability.

Pelton C’s mode of action depends on its ingredients.

1. Domperidone: It is a dopamine receptor antagonist that primarily acts on the peripheral dopamine receptors in the gastrointestinal (GI) tract. It blocks dopamine receptors in the chemoreceptor trigger zone (CTZ) located in the brain, which helps prevent or alleviate nausea and vomiting. Domperidone also acts on the smooth muscles of the GI tract, enhancing motility and facilitating the movement of food through the digestive system.
2. Cinnarizine: It is a calcium channel blocker with antihistamine properties. It primarily acts by blocking certain calcium channels, particularly those associated with blood vessels and the inner ear. By blocking calcium influx, cinnarizine helps improve blood flow to the inner ear, reducing vertigo symptoms associated with balance disorders. Additionally, cinnarizine has antihistamine activity, which can contribute to its anti-nausea effects.